Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Qi-Yong Huai"'
Publikováno v:
Molecules, Vol 19, Iss 10, Pp 16349-16372 (2014)
Curcuminoids have been reported to possess multiple bioactivities, such as antioxidant, anticancer and anti-inflammatory properties. Three novel series of curcuminoid derivatives (11a–h, 15a–h and 19a–d) with enhanced bioactivity have been synt
Externí odkaz:
https://doaj.org/article/ab1c107867954e3492939db470a82035
Publikováno v:
Molecules, Vol 21, Iss 2, p 199 (2016)
A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluat
Externí odkaz:
https://doaj.org/article/31576b4005c44c34bdf729edbd9923e9
Autor:
Wim Dehaen, Rui Wang, Chang-Xin He, Qing-Xuan Zheng, Yan Xu, Cai-Yun Zhao, Zhi-Fang Wang, Hui-Jing Li, Qi-Yong Huai, Rui Zhang
Publikováno v:
Biologicalpharmaceutical bulletin. 43(1)
Glycyrrhetinic acid (GA) is a natural product with certain antitumor activity. In order to enhance the cytotoxicity, a total of eighteen derivatives of GA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272c99cd57290ff743ddde6fde1aa1c7
https://pubmed.ncbi.nlm.nih.gov/31902913
https://pubmed.ncbi.nlm.nih.gov/31902913
Publikováno v:
Drug Design, Development and Therapy
Rui Wang,1,* Yang Li,2,* Xu-Dong Huai,3 Qing-Xuan Zheng,1 Wei Wang,1 Hui-Jing Li,4 Qi-Yong Huai1 1Marine College, Shandong University, Weihai, China; 2Zhong Yuan Academy of Biological Medicine, Liaocheng People’s Hospital/Affiliated Liaocheng Hospi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5da124203ecc998b93de7727e79096
http://europepmc.org/articles/PMC5968802
http://europepmc.org/articles/PMC5968802
Publikováno v:
Synthesis. 50:1482-1492
The iron(III) triflate catalyzed cyclization reaction of phenols and ketones is described; the reaction provides a direct approach to 4H-chromene derivatives. 4H-Chromene is an important structural fragment of many pharmaceuticals, natural products,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de1120f67e932d784012f886d4f65727
https://doi.org/10.1055/s-0036-1591021
https://doi.org/10.1055/s-0036-1591021
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:703-710
A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-dipheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c353d6f88a4666d7f5942807a6768c4
https://doi.org/10.1248/bpb.b17-00016
https://doi.org/10.1248/bpb.b17-00016
Publikováno v:
Organic Letters. 17:1473-1476
Rearrangement of dypnones to 1,3,5-triarylbenzenes is described. The reaction is proposed to involve an aldol-type self-condensation of dypnones, followed by an intramolecular [2 + 2] cycloaddition and a retro-[2 + 2] cycloaddition. The reaction goes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd815bc0d2790cbf6301a427cea33cbc
https://doi.org/10.1021/acs.orglett.5b00353
https://doi.org/10.1021/acs.orglett.5b00353
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 63:873-881
Many curcuminoid derivatives have been reported to have multiple biological activities. The aim of this study was to improve the biological activity of curcuminoids by synthesizing 16 new derivatives which combined cinnamic acids with curcuminoids, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a778e3338a83b706f39c85d46d081c8
https://doi.org/10.1248/cpb.c15-00470
https://doi.org/10.1248/cpb.c15-00470
Publikováno v:
Asian Journal of Chemistry. 26:4465-4468
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa37093c05d9c786be9ea97d180189a
https://doi.org/10.14233/ajchem.2014.16975
https://doi.org/10.14233/ajchem.2014.16975
Autor:
Yang Li, Wim Dehaen, Qing-Xuan Zheng, Rui Wang, Wei Yang, Hui-Jing Li, Yiqing Fan, Wei Wang, Qi-Yong Huai
Publikováno v:
Bioorganic Chemistry. 88:102951
Oleanolic acid (OA) and glycyrrhetinic acid (GA) are natural products with anticancer effects. Cinnamic acid (CA) and its derivatives also exhibited certain anticancer activity. In order to improve the anticancer activity of OA and GA, we designed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e738c981331a455910c8e6a310c460
https://doi.org/10.1016/j.bioorg.2019.102951
https://doi.org/10.1016/j.bioorg.2019.102951