Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Qi-Peng Shu"'
Autor:
Shang-Ze Li, Qi-Peng Shu, Hai-Meng Zhou, Yu-Ying Liu, Meng-Qi Fan, Xin-Yi Liang, Lin-Zhi Qi, Ya-Nan He, Xue-Yi Liu, Xue-Hua Du, Xi-Chen Huang, Yu-Zhen Chen, Run-Lei Du, Yue-Xiu Liang, Xiao-Dong Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pattern in the later stage of a
Externí odkaz:
https://doaj.org/article/3f826d23a77e4eae86987c5233015fc0
Autor:
Tao Liu, Meng-Qi Fan, Xiao-Xiao Xie, Qi-Peng Shu, Xue-Hua Du, Lin-Zhi Qi, Xiao-Dong Zhang, Ming-Hui Zhang, Guang Shan, Run-Lei Du, Shang-Ze Li
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant progression of various cancers. Recent studies have suggested that CTNNB1 hyperactivation is closely related to the occurrence and development of bladder cance
Externí odkaz:
https://doaj.org/article/77b0d8d306b94929b2993eeac723798f
Autor:
Shang-Ze Li, Ze-Yan Zhang, Jie Chen, Ming-You Dong, Xue-Hua Du, Jie Gao, Qi-Peng Shu, Chao Li, Xin-Yi Liang, Zhi-Hao Ding, Run-Lei Du, Junli Wang, Xiao-Dong Zhang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear
Externí odkaz:
https://doaj.org/article/f9f2d59e373445dfa84580f40a5d36f6
Autor:
Shang-Ze Li, Qi-Peng Shu, Yang Song, Hui-Hui Zhang, Yi Liu, Bing-Xue Jin, Tian-Zi Liuyu, Chao Li, Xi-Chen Huang, Run-Lei Du, Wei Song, Bo Zhong, Xiao-Dong Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that ex
Externí odkaz:
https://doaj.org/article/ff479f2686d243949b20b20a1875edd4
Autor:
Li Chao, Tianzi Liuyu, Xi-Chen Huang, Wei Song, Run-Lei Du, Hui-Hui Zhang, Bing-Xue Jin, Yang Song, Xiao-Dong Zhang, Yi Liu, Bo Zhong, Shang-Ze Li, Qi-Peng Shu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
MAVS is essential for antiviral immunity, but the molecular mechanisms responsible for its tight regulation remain poorly understood. Here, we show that NLK inhibits the antiviral immune response during viral infection by targeting MAVS for degradati
Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1
Autor:
Xiao-Dong Zhang, Feng Zeng, Jun Xu, Hui-Hui Zhang, Jun Li, Xue-Min Song, Run-Lei Du, Qi-Peng Shu, Jian-Wei Ren, Shang-Ze Li
Publikováno v:
Cancer letters. 431
Control of E2F1 activity is restricted via its interactions with RB1 and HDAC1. However, the detailed regulatory mechanisms underlying the E2F1/HDAC1 complex remain elusive. Here, we report that Nemo-like kinase (NLK) boosts cell cycle progression, w