Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Qi-Jing Li"'
Autor:
Lianmei Tan, Tao Yin, Handan Xiang, Liuyang Wang, Poorva Mudgal, Junying Chen, Yi Ding, Guoping Wang, Bryan Jian Wei Lim, Yuqi Huang, De Huang, Yaosi Liang, Peter B. Alexander, Kun Xiang, Ergang Wang, Chengsong Yan, Zhehao Ma, Minjia Tan, Qi-Jing Li, Xiao-Fan Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Immunotherapy successfully complements traditional cancer treatment. However, primary and acquired resistance might limit efficacy. Reduced antigen presentation by MHC-I has been identified as potential resistance factor. Here we show that t
Externí odkaz:
https://doaj.org/article/c5d42c601a2d43d98563c3b7367d8b29
Autor:
Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B. Alexander, Qi‐Jing Li, Tso‐Pang Yao, Zhao Zhang, Xiao‐Fan Wang
Publikováno v:
Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)
Abstract The essential branched‐chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis and energy metabolism. Despite their widespread use as nutritional supplements, BCAAs’ full effects on mammalian ph
Externí odkaz:
https://doaj.org/article/31eefbea3ab7422289b0a16e728f1a35
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Most single-cell RNA sequencing (scRNA-seq) analyses begin with cell clustering; thus, the clustering accuracy considerably impacts the validity of downstream analyses. In contrast with the abundance of clustering methods, the tools to asses
Externí odkaz:
https://doaj.org/article/e890f60a76644652938dd0652f203383
Autor:
Adam M. Swartz, Kendra L. Congdon, Smita K. Nair, Qi-Jing Li, James E. Herndon, Carter M. Suryadevara, Katherine A. Riccione, Gary E. Archer, Pamela K. Norberg, Luis A. Sanchez-Perez, John H. Sampson
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific immune response. Sev
Externí odkaz:
https://doaj.org/article/630d5dbd82df4a1bb95d08b2e6228b95
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Tumor purity is the percent of cancer cells present in a sample of tumor tissue. The non-cancerous cells (immune cells, fibroblasts, etc.) have an important role in tumor biology. The ability to determine tumor purity is important
Externí odkaz:
https://doaj.org/article/60e0f816266947b29a2b7ca97258148a
Autor:
Ming Zheng, Xin Zhang, Yinghui Zhou, Juan Tang, Qing Han, Yang Zhang, Qingshan Ni, Gang Chen, Qingzhu Jia, Haili Yu, Siqi Liu, Elizabeth Robins, Ning Jenny Jiang, Ying Wan, Qi-Jing Li, Zhi-Nan Chen, Ping Zhu
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 414-426 (2019)
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease with worldwide high prevalence. Although AS is strongly associated with HLA-B27 MHC-I antigen presentation, the role played by αβ T cells in AS remains elusive. Methods: Util
Externí odkaz:
https://doaj.org/article/f8783788e24c4bafbff11be48ed9dc65
Autor:
Jie Zhou, Shuo Huang, Zhongyu Wang, Jiani Huang, Liang Xu, Xuefeng Tang, Yisong Y. Wan, Qi-jing Li, Alistair L. J. Symonds, Haixia Long, Bo Zhu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
EZH2-mediated methylatation of histone 3 is essential for immune regulation. Here, the authors show that EZH2 inhibitors attenuate experimental colitis in mice by promoting the development of myeloid-derived suppressor cells, and delay the onset of c
Externí odkaz:
https://doaj.org/article/725ed1506054442e94b8485433a49e9f
Autor:
Qingzhu Jia, Wei Wu, Yuqi Wang, Peter B. Alexander, Chengdu Sun, Zhihua Gong, Jia-Nan Cheng, Huaibo Sun, Yanfang Guan, Xuefeng Xia, Ling Yang, Xin Yi, Yisong Y. Wan, Haidong Wang, Ji He, P. Andrew Futreal, Qi-Jing Li, Bo Zhu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Intratumoral immunity heterogeneity is poorly characterized. Here the authors apply exome sequencing, transcriptome profiling and T-cell repertoire profiling to multiple loci of non-small-cell lung cancer patients' biopsies and find high spatial immu
Externí odkaz:
https://doaj.org/article/e293331d105f4f4b8efabbf555c989e7
Autor:
Guoping Wang, Poorva Mudgal, Liuyang Wang, Timothy Wai Ho Shuen, Haiyang Wu, Peter B Alexander, Who-Whong Wang, Ying Wan, Han Chong Toh, Xiao-Fan Wang, Qi-Jing Li
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
The past decade has witnessed the gradual and steady progress of adoptive T cell therapy in treating various types of cancer. In combination with gemcitabine and carboplatin chemotherapy, we previously conducted a clinical trial, NCT00690872, to trea
Externí odkaz:
https://doaj.org/article/83cdf98784284535bca66002a3cda514
Autor:
Qingshan Ni, Jianyang Zhang, Zihan Zheng, Gang Chen, Laura Christian, Juha Grönholm, Haili Yu, Daxue Zhou, Yuan Zhuang, Qi-Jing Li, Ying Wan
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Recent progress in high throughput sequencing technologies has provided an opportunity to probe T cell receptor (TCR) repertoire, bringing about an explosion of TCR sequencing data and analysis tools. For easier and more heuristic analysis TCR sequen
Externí odkaz:
https://doaj.org/article/825e11438ae743409cf60cb2d22b490a