Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Qi-Dong You"'
Autor:
Nan-Nan Chen, Han Zhang, Qiang-Sheng Zhu, Ting Zeng, Wei Dai, Ye-Ling Zhou, Guo-Feng Xin, Bei-Duo Wu, Si-Jia Gong, Zheng-Yu Jiang, Qi-Dong You, Xiao-Li Xu
Publikováno v:
Journal of Medicinal Chemistry. 66:5584-5610
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe0305ceb77f03a55bff478a7fb7e62f
https://doi.org/10.1021/acs.jmedchem.2c02046
https://doi.org/10.1021/acs.jmedchem.2c02046
Autor:
Hui Li, Sheng-Lie Zhang, Yan-Han Jia, Qian Li, Zi-Wen Feng, Shi-Duo Zhang, Wei Zheng, Ye-Ling Zhou, Lin-Lin Li, Xue-Chun Liu, Ya-Qiong Chen, Hui Peng, Qi-Dong You, Xiao-Li Xu
Publikováno v:
Journal of Medicinal Chemistry. 66:2804-2831
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a394cad53d18663838fab02f2337de50
https://doi.org/10.1021/acs.jmedchem.2c01862
https://doi.org/10.1021/acs.jmedchem.2c01862
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
The Keap1-Nrf2-ARE pathway regulates the constitutive and inducible transcription of various genes that encode detoxification enzymes, antioxidant proteins and anti-inflammatory proteins and has pivotal roles in the defence against cellular oxidative
Externí odkaz:
https://doaj.org/article/5b22e7dffc5d4f6ba875f79e6140153a
Autor:
Xuetao Chen, Fanying Meng, Jingtian Zhang, Zijian Zhang, Xuan Ye, Weikun Zhang, Yuanyuan Tong, Xinrui Ji, Rujun Xu, Xiao-Li Xu, Qi-Dong You, Zheng-Yu Jiang
Publikováno v:
European journal of medicinal chemistry. 238
Sepsis has long been a major health problem worldwide. It threatens the lives of hospitalized patients and has been one of the leading causes of death in hospitalized patients over the past decades. BRD4 has been regarded as a potential target for se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f83cfc4d43ccdc9100c36b953a65dda
https://pubmed.ncbi.nlm.nih.gov/35544982
https://pubmed.ncbi.nlm.nih.gov/35544982
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 1, Iss 4, Pp 240-247 (2011)
Ligand- and structure-based virtual screening methods were employed to identify novel non-hydroxamate histone deacetylase (HDAC) inhibitors. Based on the newly identified hit compound 17a, three series of compounds were synthesized and evaluated for
Externí odkaz:
https://doaj.org/article/31ccf24f1e8e4205b9eba779a67681ed
Autor:
Peng-Ju, Zhu, Ze-Zhou, Yu, Yi-Fei, Lv, Jing-Long, Zhao, Yuan-Yuan, Tong, Qi-Dong, You, Zheng-Yu, Jiang
Publikováno v:
Journal of medicinal chemistry. 64(15)
Myeloid cell leukemia 1 (Mcl-1) protein is a key negative regulator of apoptosis, and developing Mcl-1 inhibitors has been an attractive strategy for cancer therapy. Herein, we describe the rational design, synthesis, and structure-activity relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02949a07bf6defc2c7b538ca0734d091
https://pubmed.ncbi.nlm.nih.gov/34342996
https://pubmed.ncbi.nlm.nih.gov/34342996
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106458 (2014)
The patients diagnosed with melanoma have a bad prognosis for early regional invasion and distant metastases. Wogonin (5,7-dihydroxy-8-methoxyflavone) is one of the active components of flavonoids that extracts from Scutellariae radix. Several previo
Externí odkaz:
https://doaj.org/article/2c0ac59a5c634eec967ba4de7a03fee2
Autor:
Zheng-Yu Jiang, Hong-Xi Chu, Mei-Yang Xi, Ting-Ting Yang, Jian-Min Jia, Jing-Jie Huang, Xiao-Ke Guo, Xiao-Jin Zhang, Qi-Dong You, Hao-Peng Sun
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75076 (2013)
Degradation of certain proteins through the ubiquitin-proteasome pathway is a common strategy taken by the key modulators responsible for stress responses. Kelch-like ECH-associated protein-1(Keap1), a substrate adaptor component of the Cullin3 (Cul3
Externí odkaz:
https://doaj.org/article/6d8c0d3d50e440ac8480a9b7941746ed
Autor:
Yong Yang, Xian-Jing Li, Zhen Chen, Xuan-Xuan Zhu, Jing Wang, Lin-bo Zhang, Lei Qiang, Yan-Jun Ma, Zhi-yu Li, Qing-Long Guo, Qi-Dong You
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50811 (2012)
In response to ionizing irradiation and certain chemotherapeutic agents, dying tumor cells elicit a potent anticancer immune response. However, the potential effect of wogonin (5,7-dihydroxy-8-methoxyflavone) on cancer immunogenicity has not been stu
Externí odkaz:
https://doaj.org/article/69a3b987b1734b9090dd8a5f86135d04
Publikováno v:
European Journal of Medicinal Chemistry. 141:1-14
In order to discover novel Hsp90 inhibitors targeting the C-terminal ATP binding pocket, a novobiocin derivative based ROCS model was constructed for virtual screening. Compound 13 was identified as the lead compound and then systematical structure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11c7ede165e8a11b6ce7e28b2adf7a1
https://doi.org/10.1016/j.ejmech.2017.07.080
https://doi.org/10.1016/j.ejmech.2017.07.080