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Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.

Autor: Zhang RH; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Regenerative Medicine of Guizhou Province, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, 550004, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Chen T; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Xiong QQ; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Wang S; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Chen GQ; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Zhang WL; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Yuan HF; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Zhao YL; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Liu T; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Huang Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China., Zhou M; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China. Electronic address: gmu_mengzhou@163.com., Yang CL; Department of Pharmacy, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China. Electronic address: yangcl714@163.com., Liao SG; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China. Electronic address: lshangg@163.com., Li YJ; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, China. Electronic address: liyongjun026@gmc.edu.cn.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 15; Vol. 282, pp. 117059. Date of Electronic Publication: 2024 Nov 15.

The fracture and perforation failure analysis of downhole tubes.

Autor: Ding H; Tubular Goods Research Institute, China National Petroleum Corporation & State Key Laboratory of Oil and Gas Equipment, Shaanxi, Xi'an, 710065, China.; Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an, 710072, China., Li HB; Tubular Goods Research Institute, China National Petroleum Corporation & State Key Laboratory of Oil and Gas Equipment, Shaanxi, Xi'an, 710065, China., Zhang Z; Tubular Goods Research Institute, China National Petroleum Corporation & State Key Laboratory of Oil and Gas Equipment, Shaanxi, Xi'an, 710065, China., Qi DT; Tubular Goods Research Institute, China National Petroleum Corporation & State Key Laboratory of Oil and Gas Equipment, Shaanxi, Xi'an, 710065, China., Qi GQ; Tubular Goods Research Institute, China National Petroleum Corporation & State Key Laboratory of Oil and Gas Equipment, Shaanxi, Xi'an, 710065, China.; Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an, 710072, China., Cai XH; Tubular Goods Research Institute, China National Petroleum Corporation & State Key Laboratory of Oil and Gas Equipment, Shaanxi, Xi'an, 710065, China.

Publikováno v: Heliyon [Heliyon] 2024 Oct 02; Vol. 10 (19), pp. e38896. Date of Electronic Publication: 2024 Oct 02 (Print Publication: 2024).

Upregulation of Long Noncoding RNA MAGOH-DT Mediates TNF-α and High Glucose-Induced Endothelial-Mesenchymal Transition in Arteriosclerosis Obliterans.

Autor: Wang KJ; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University., Zhang YX; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Division of Hypertension and Vascular Diseases, Department of Cardiology, Heart Center, The First Affiliated Hospital, Sun Yat-sen University., Mo ZW; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University., Li ZL; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University., Wang M; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University., Wang R; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University., Wang ZC; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University., Chang GQ; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University., Wu WB; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University.; National-Local Joint Engineering Laboratory of Vascular Diseases Treatment, The First Affiliated Hospital, Sun Yat-sen University.; Guangdong Engineering Laboratoty of Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University.

Publikováno v: The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2024 Sep 27; Vol. 263 (4), pp. 227-238. Date of Electronic Publication: 2024 May 30.