Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Qi‐Xiang Li"'
Autor:
Tao Yang, Hang Ke, Jinping Liu, Xiaoyu An, Jia Xue, Jinying Ning, Feng Hao, Lingxin Xiong, Cen Chen, Yueying Wang, Jia Zheng, Bing Gao, Zhengzheng Bao, Kefeng Gong, Lei Zhang, Faming Zhang, Sheng Guo, Qi-Xiang Li
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract CSF1R is a receptor tyrosine kinase responsible for the growth/survival/polarization of macrophages and overexpressed in some AML patients. We hypothesized that a novel multi-kinase inhibitor (TKi), narazaciclib (HX301/ON123300), with high p
Externí odkaz:
https://doaj.org/article/2a1e2e110c10476c81d7c29a2fc5961e
Autor:
Jia Xue, Xiaobo Chen, Xiaoyu An, Jingjing Wang, Mingfa Zang, Binchen Mao, Sheng Guo, Tao Yang, Rajendra Kumari, Qi-Xiang Li
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303171 (2024)
Tumor microenvironment (TME) is a complex dynamic system with many tumor-interacting components including tumor-infiltrating leukocytes (TILs), cancer associated fibroblasts, blood vessels, and other stromal constituents. It intrinsically affects tum
Externí odkaz:
https://doaj.org/article/0bb3bb128dee4ec69e079996356cfe36
Autor:
Hang Ke, Faming Zhang, Jingjing Wang, Lingxin Xiong, Xiaoyu An, Xiaolong Tu, Cen Chen, Yueying Wang, Binchen Mao, Sheng Guo, Cunxiang Ju, Xiangfei He, Ruilin Sun, Lei Zhang, Owen A. O’Connor, Qi-Xiang Li
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Both PD1/PD-L1 and CD47 blockades have demonstrated limited activity in most subtypes of NHL save NK/T-cell lymphoma. The hemotoxicity with anti-CD47 agents in the clinic has been speculated to account for their limitations. Herein we descri
Externí odkaz:
https://doaj.org/article/aaf54bd9d4b649b8a555d5a6dca9d4c5
Autor:
Hongxia Li, Emily B. Harrison, Huizhong Li, Koichi Hirabayashi, Jing Chen, Qi-Xiang Li, Jared Gunn, Jared Weiss, Barbara Savoldo, Joel S. Parker, Chad V. Pecot, Gianpietro Dotti, Hongwei Du
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. Here the authors design B7-H3 targeting CAR-T cells engineered to express the chemokine receptor CCR2b, and show improved accumulation in the brain and enh
Externí odkaz:
https://doaj.org/article/6b5527f7df4141638fa2ab38499267ce
Autor:
Ying Jin, Xiaoyu An, Binchen Mao, Ruilin Sun, Rajendra Kumari, Xiaobo Chen, Yongli Shan, Mingfa Zang, Ling Xu, Jan Muntel, Kristina Beeler, Roland Bruderer, Lukas Reiter, Sheng Guo, Demin Zhou, Qi-Xiang Li, Xuesong Ouyang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs). We modeled loss of function (LOF) in fo
Externí odkaz:
https://doaj.org/article/f458fcf37994447d8b6641e56cd067f3
Autor:
Xiaoxi Xu, Rajendra Kumari, Jun Zhou, Jing Chen, Binchen Mao, Jingjing Wang, Meiling Zheng, Xiaolong Tu, Xiaoyu An, Xiaobo Chen, Likun Zhang, Xiaoli Tian, Haojie Wang, Xin Dong, Zhengzheng Bao, Sheng Guo, Xuesong Ouyang, Limei Shang, Fei Wang, Xuefei Yan, Rui Zhang, Robert G J Vries, Hans Clevers, Qi-Xiang Li
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0279821 (2023)
Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have been created and used extensiv
Externí odkaz:
https://doaj.org/article/a8c4f6089dc34895bc5e8de7db9ea1ac
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Mouse clinical trials (MCTs) are becoming wildly used in pre-clinical oncology drug development, but a statistical framework is yet to be developed. In this study, we establish such as framework and provide general guidelines on t
Externí odkaz:
https://doaj.org/article/af1a7da929654af88e9d356770b2de55
Publikováno v:
Gastroenterology Research and Practice, Vol 2016 (2016)
Background. Endoscopic retrograde cholangiopancreatography (ERCP) is an established treatment modality for bile duct disorders, but patients have a risk of post-ERCP pancreatitis (PEP) and biliary sepsis. Aim. To evaluate the effectiveness and safety
Externí odkaz:
https://doaj.org/article/5ced4276f7be48e0b6a0a9a824d3f6ec
Autor:
Ning Ke, Aaron Albers, Gisela Claassen, De-hua Yu, Jon E. Chatterton, Xiuyuan Hu, Bernd Meyhack, Flossie Wong-Staal, Qi-Xiang Li
Publikováno v:
BioTechniques, Vol 36, Iss 5, Pp 826-833 (2004)
Soft agar growth, used to measure cell anchorage-independent proliferation potential, is one of the most important and most commonly used assays to detect cell transformation. However, the traditional soft agar assay is time-consuming, labor-intensiv
Externí odkaz:
https://doaj.org/article/9fa135bf8e21487ea30e62b1edc78b17
Autor:
De-Hua Yu, James Macdonald, Guohong Liu, Amy S Lee, Mimi Ly, Timothy Davis, Ning Ke, Demin Zhou, Flossie Wong-Staal, Qi-Xiang Li
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3951 (2008)
We identified pyrvinium pamoate, an old anthelminthic medicine, which preferentially inhibits anchorage-independent growth of cancer cells over anchorage-dependent growth (approximately 10 fold). It was also reported by others to have anti-tumor acti
Externí odkaz:
https://doaj.org/article/0b5987ccb2834d7ba03746b00aaeb4ba