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Akademický článek

CtrA activates the expression of glutathione S-transferase conferring oxidative stress resistance to Ehrlichia chaffeensis

Autor: Qi’an Liang, Jiaqi Yan, Shuwen Zhang, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis (HME), is a Gram-negative obligatory intracellular bacterium, which infects and multiplies in human monocytes and macrophages. Host immune cells produce reactive oxygen specie

Externí odkaz: https://doaj.org/article/13f90630af59424a83c9f3017d64d225

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Akademický článek

Glutathione Synthesis Regulated by CtrA Protects Ehrlichia chaffeensis From Host Cell Oxidative Stress

Autor: Jiaqi Yan, Qi’an Liang, Zhouyi Chai, Nan Duan, Xiaoxiao Li, Yajing Liu, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Ehrlichia chaffeensis, a small Gram-negative obligatory intracellular bacterium, infects human monocytes or macrophages, and causes human monocytic ehrlichiosis, one of the most prevalent, life-threatening emerging zoonoses. Reactive oxygen species a

Externí odkaz: https://doaj.org/article/3403d619255e4fb89e07c7f1c67effe1

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Akademický článek

Molecular Characterization of WCK 5222 (Cefepime/Zidebactam)-Resistant Mutants Developed from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate

Autor: Xiaolei Pan, Xinrui Zhao, Yuqin Song, Huan Ren, Zhenyang Tian, Qi’an Liang, Yongxin Jin, Fang Bai, Zhihui Cheng, Jie Feng, Weihui Wu

Publikováno v: Microbiology Spectrum, Vol 10, Iss 1 (2022)

ABSTRACT WCK 5222 (cefepime/zidebactam) is a β-lactam/β-lactamase inhibitor combination that is effective against a broad range of highly drug-resistant bacterial pathogens, including those producing metallo-β-lactamase. In this study, we isolated

Externí odkaz: https://doaj.org/article/ef5477ab12c24387a6afcb89a6e40657

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