Anti-Allergic and Anti-Inflammatory Effects of Lidocaine-Derived Organic Compounds in a House Dust Mite-Induced Allergic Rhinitis Mouse Model.

Autor: Shin SH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Ye MK; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Chae MH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Geum SY; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Aboraia AS; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Abdel-Aal AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Qayed WS; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., El-Wahab HAAA; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Abou-Ghadir OF; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Aboul-Fadl T; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Publikováno v: Biomedicines [Biomedicines] 2024 Aug 29; Vol. 12 (9). Date of Electronic Publication: 2024 Aug 29.

Effects of Lidocaine-Derived Organic Compounds on Eosinophil Activation and Survival.

Autor: Shin SH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Ye MK; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Chae MH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Geum SY; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea., Aboraia AS; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Abdel-Aal AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Qayed WS; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Abd El-Wahab HAA; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Abou-Ghadir OF; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Aboul-Fadl T; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Jul 27; Vol. 28 (15). Date of Electronic Publication: 2023 Jul 27.

Synthesis, biological evaluation, and molecular modeling studies of acetophenones-tethered 1,2,4-triazoles and their oximes as epidermal growth factor receptor inhibitors.

Autor: El-Wahab HAAA; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Ali AM; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Abdel-Rahman HM; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt., Qayed WS; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2022 Dec; Vol. 100 (6), pp. 981-993. Date of Electronic Publication: 2021 Nov 22.

In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations.

Autor: Qayed WS; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Ferreira RS; Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém 66075-110, Brazil., Silva JRA; Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém 66075-110, Brazil.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Sep 14; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 14.

Ionic liquid of ketoprofen-piperine modulates the pharmaceutical and therapeutic characters of ketoprofen.

Autor: Hassan SA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt; Institute for Drug Development and Innovation Research, Assiut University, Assiut, Egypt., Gad SF; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN, USA., Abdu-Allah HHM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Qayed WS; Department of Medicinal Chemistry, Faculty of Pharmacy, Assuit University, Assuit 71526, Egypt., AbouElmagd SA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt; Institute for Drug Development and Innovation Research, Assiut University, Assiut, Egypt. Electronic address: sabouelm@aun.edu.eg., Ibrahim EA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt; Institute for Drug Development and Innovation Research, Assiut University, Assiut, Egypt.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2022 May 25; Vol. 620, pp. 121724. Date of Electronic Publication: 2022 Apr 09.