Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Autor: Erzurumluoglu, AM, Liu, M, Jackson, VE, Barnes, DR, Datta, G, Melbourne, CA, Young, R, Batini, C, Surendran, P, Jiang, T, Adnan, SD, Afaq, S, Agrawal, A, Altmaier, E, Antoniou, AC, Asselbergs, FW, Baumbach, C, Beirut, L, Bertelsen, S, Boehnke, M, Bots, ML, Brazel, DM, Chambers, JC, Chang-Claude, J, Chen, C, Corley, J, Chou, Y-L, David, SP, de Boer, RA, de Leeuw, CA, Dennis, JG, Dominiczak, AF, Dunning, AM, Easton, DF, Eaton, C, Elliott, P, Evangelou, E, Faul, JD, Foroud, T, Goate, A, Gong, J, Grabe, HJ, Haessler, J, Haiman, C, Hallmans, G, Hammerschlag, AR, Harris, SE, Hattersley, A, Heath, A, Hsu, C, Iacono, WG, Kanoni, S, Kapoor, M, Kaprio, J, Kardia, SL, Karpe, F, Kontto, J, Kooner, JS, Kooperberg, C, Kuulasmaa, K, Laakso, M, Lai, D, Langenberg, C, Le, N, Lettre, G, Loukola, A, Luan, J, Madden, PAF, Mangino, M, Marioni, RE, Marouli, E, Marten, J, Martin, NG, McGue, M, Michailidou, K, Mihailov, E, Moayyeri, A, Moitry, M, Müller-Nurasyid, M, Naheed, A, Nauck, M, Neville, MJ, Nielsen, SF, North, K, Perola, M, Pharoah, PDP, Pistis, G, Polderman, TJ, Posthuma, D, Poulter, N, Qaiser, B, Rasheed, A, Reiner, A, Renström, F, Rice, J, Rohde, R, Rolandsson, O, Samani, NJ, Samuel, M, Schlessinger, D, Scholte, SH, Scott, RA, Sever, P, Shao, Y, Shrine, N, Smith, JA, Starr, JM, Stirrups, K, Stram, D, Stringham, HM, Tachmazidou, I, Tardif, J-C, Thompson, DJ, Tindle, HA, Tragante, V, Trompet, S, Turcot, V, Tyrrell, J, Vaartjes, I, van der Leij, AR, van der Meer, P, Varga, TV, Verweij, N, Völzke, H, Wareham, NJ, Warren, HR, Weir, DR, Weiss, S, Wetherill, L, Yaghootkar, H, Yavas, E, Jiang, Y, Chen, F, Zhan, X, Zhang, W, Zhao, W, Zhou, K, Amouyel, P, Blankenberg, S, Caulfield, MJ, Chowdhury, R, Cucca, F, Deary, IJ, Deloukas, P, Di Angelantonio, E, Ferrario, M, Ferrières, J, Franks, PW, Frayling, TM, Frossard, P, Hall, IP, Hayward, C, Jansson, J-H, Jukema, JW, Kee, F, Männistö, S, Metspalu, A, Munroe, PB, Nordestgaard, BG, Palmer, CNA, Salomaa, V, Sattar, N, Spector, T, Strachan, DP, Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ Consortium, van der Harst, P, Zeggini, E, Saleheen, D, Butterworth, AS, Wain, LV, Abecasis, GR, Danesh, J, Tobin, MD, Vrieze, S, Liu, DJ, Howson, JMM

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::2dcc9e0cb996255a99cde2618200dfa2
https://openaccess.sgul.ac.uk/id/eprint/110459/20/s41380-018-0313-0.pdf

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Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Autor: Stringer, S., Minică, C. C., Verweij, K. J.H., Mbarek, Hamdi, Bernard, M., Derringer, Jaime, van Eijk, K. R., Isen, J. D., Loukola, Anu, Maciejewski, D. F., Mihailov, E., van der Most, Peter J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R.G., Ware, James S., Abdellaoui, A., Bigdeli, T. B., Branje, S. J.T., Brown, A.S., Bruinenberg, M., Casas, M., Esko, Tonu, Garcia-Martinez, I., Gordon, Scott D., Harris, Juliette M, Hartman, Catharine A, Henders, Anjali K., Heath, Andrew C., Hickie, Ian B., Hickman, M., Hopfer, C. J., Hottenga, J.J., Huizink, A.C., Irons, D. E., Kahn, R. S., Korhonen, T.K., Kranzler, H. R., Krauter, K., van Lier, P.A.C., Lubke, G.H., Madden, Pamela A. F., Mägi, Reedik, McGue, M. K., Medland, Sarah E., Meeus, W.H.J., Miller, Michael B., Montgomery, Grant W., Nivard, Michel G, Nolte, Ilja M., Oldehinkel, Albertine J., Pausova, Zdenka, Qaiser, B., Quaye, Lydia, Ramos-Quiroga, J. A., Richarte, V., Rose, R.J., Shin, J.J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, Margaret J., Koot, H.M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, Jaakko, Boks, M. P., Snieder, H., Spector, T.D., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, Dorret I., Iacono, William G, Martin, Nicholas G., Gillespie, N. A., Derks, Eske M., Vink, J. M.

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10691::2409bcd19e096c4455e4f7f76ff1fc18
https://dspace.library.uu.nl/handle/1874/353093

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