Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Autor: Erzurumluoglu, AM, Liu, M, Jackson, VE, Barnes, DR, Datta, G, Melbourne, CA, Young, R, Batini, C, Surendran, P, Jiang, T, Adnan, SD, Afaq, S, Agrawal, A, Altmaier, E, Antoniou, AC, Asselbergs, FW, Baumbach, C, Beirut, L, Bertelsen, S, Boehnke, M, Bots, ML, Brazel, DM, Chambers, JC, Chang-Claude, J, Chen, C, Corley, J, Chou, Y-L, David, SP, de Boer, RA, de Leeuw, CA, Dennis, JG, Dominiczak, AF, Dunning, AM, Easton, DF, Eaton, C, Elliott, P, Evangelou, E, Faul, JD, Foroud, T, Goate, A, Gong, J, Grabe, HJ, Haessler, J, Haiman, C, Hallmans, G, Hammerschlag, AR, Harris, SE, Hattersley, A, Heath, A, Hsu, C, Iacono, WG, Kanoni, S, Kapoor, M, Kaprio, J, Kardia, SL, Karpe, F, Kontto, J, Kooner, JS, Kooperberg, C, Kuulasmaa, K, Laakso, M, Lai, D, Langenberg, C, Le, N, Lettre, G, Loukola, A, Luan, J, Madden, PAF, Mangino, M, Marioni, RE, Marouli, E, Marten, J, Martin, NG, McGue, M, Michailidou, K, Mihailov, E, Moayyeri, A, Moitry, M, Müller-Nurasyid, M, Naheed, A, Nauck, M, Neville, MJ, Nielsen, SF, North, K, Perola, M, Pharoah, PDP, Pistis, G, Polderman, TJ, Posthuma, D, Poulter, N, Qaiser, B, Rasheed, A, Reiner, A, Renström, F, Rice, J, Rohde, R, Rolandsson, O, Samani, NJ, Samuel, M, Schlessinger, D, Scholte, SH, Scott, RA, Sever, P, Shao, Y, Shrine, N, Smith, JA, Starr, JM, Stirrups, K, Stram, D, Stringham, HM, Tachmazidou, I, Tardif, J-C, Thompson, DJ, Tindle, HA, Tragante, V, Trompet, S, Turcot, V, Tyrrell, J, Vaartjes, I, van der Leij, AR, van der Meer, P, Varga, TV, Verweij, N, Völzke, H, Wareham, NJ, Warren, HR, Weir, DR, Weiss, S, Wetherill, L, Yaghootkar, H, Yavas, E, Jiang, Y, Chen, F, Zhan, X, Zhang, W, Zhao, W, Zhou, K, Amouyel, P, Blankenberg, S, Caulfield, MJ, Chowdhury, R, Cucca, F, Deary, IJ, Deloukas, P, Di Angelantonio, E, Ferrario, M, Ferrières, J, Franks, PW, Frayling, TM, Frossard, P, Hall, IP, Hayward, C, Jansson, J-H, Jukema, JW, Kee, F, Männistö, S, Metspalu, A, Munroe, PB, Nordestgaard, BG, Palmer, CNA, Salomaa, V, Sattar, N, Spector, T, Strachan, DP, Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ Consortium, van der Harst, P, Zeggini, E, Saleheen, D, Butterworth, AS, Wain, LV, Abecasis, GR, Danesh, J, Tobin, MD, Vrieze, S, Liu, DJ, Howson, JMM

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::2dcc9e0cb996255a99cde2618200dfa2
https://openaccess.sgul.ac.uk/id/eprint/110459/20/s41380-018-0313-0.pdf

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Autor: Stringer, S, Minică, CC, Verweij, KJH, Mbarek, H, Bernard, M, Derringer, J, van Eijk, KR, Isen, JD, Loukola, A, Maciejewski, DF, Mihailov, E, van der Most, PJ, Sánchez-Mora, C, Roos, L, Sherva, R, Walters, R, Ware, JJ, Abdellaoui, A, Bigdeli, TB, Branje, SJT, Brown, SA, Bruinenberg, M, Casas, M, Esko, T, Garcia-Martinez, I, Gordon, SD, Harris, JM, Hartman, CA, Henders, AK, Heath, AC, Hickie, IB, Hickman, M, Hopfer, CJ, Hottenga, JJ, Huizink, AC, Irons, DE, Kahn, RS, Korhonen, T, Kranzler, HR, Krauter, K, van Lier, PAC, Lubke, GH, Madden, PAF, Mägi, R, McGue, MK, Medland, SE, Meeus, WHJ, Miller, MB, Montgomery, GW, Nivard, MG, Nolte, IM, Oldehinkel, AJ, Pausova, Z, Qaiser, B, Quaye, L, Ramos-Quiroga, JA, Richarte, V, Rose, RJ, Shin, J, Stallings, MC, Stiby, AI, Wall, TL, Wright, MJ, Koot, HM, Paus, T, Hewitt, JK, Ribasés, M, Kaprio, J, Boks, MP, Snieder, H, Spector, T, Munafò, MR, Metspalu, A, Gelernter, J, Boomsma, DI, Iacono, WG, Martin, NG, Gillespie, NA, Derks, EM, Vink, JM

Publikováno v: Translational psychiatry, vol 6, iss 3

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c266db0217153b22fe8521fead4c618d
https://escholarship.org/uc/item/6pv8d191

The prevalence of respiratory symptoms and diseases and declined lung function among foundry workers.

Autor: Koskela, Kirsi^1,2 (AUTHOR) kirsi.koskela@tuni.fi, Lehtimäki, Lauri³ (AUTHOR), Uitti, Jukka¹ (AUTHOR), Oksa, Panu² (AUTHOR), Tikkakoski, Antti⁴ (AUTHOR), Sauni, Riitta¹ (AUTHOR)

Publikováno v: Journal of Occupational Medicine & Toxicology. 10/24/2024, Vol. 19 Issue 1, p1-10. 10p.

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Autor: Erzurumluoglu AM; Department of Health Sciences, University of Leicester, Leicester, UK., Liu M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Jackson VE; Department of Health Sciences, University of Leicester, Leicester, UK.; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, 3052, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, 3010, Parkville, Australia., Barnes DR; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Datta G; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Melbourne CA; Department of Health Sciences, University of Leicester, Leicester, UK., Young R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Batini C; Department of Health Sciences, University of Leicester, Leicester, UK., Surendran P; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Jiang T; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Adnan SD; National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh., Afaq S; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK., Agrawal A; Department of Psychiatry, Washington University, St. Louis, MO, USA., Altmaier E; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Asselbergs FW; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.; Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, UK., Baumbach C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Bierut L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Bertelsen S; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands.; Center for Circulatory Health, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands., Brazel DM; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.; Department of Cardiology, Ealing Hospital, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.; Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany., Chen C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Corley J; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Chou YL; Department of Psychiatry, Washington University, St. Louis, MO, USA., David SP; Department of Medicine, Stanford University, Stanford, CA, USA., de Boer RA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., de Leeuw CA; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands., Dennis JG; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK., Eaton C; Department of Epidemiology, University of Washington, Seattle, WA, USA., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK.; National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare NHS Trust and Imperial College London, London, UK.; UK Dementia Research Institute (UK DRI) at Imperial College London, London, UK., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Goate A; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gong J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany., Haessler J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Haiman C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Hallmans G; Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden., Hammerschlag AR; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Hattersley A; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK., Heath A; Department of Psychiatry, Washington University, St. Louis, MO, USA., Hsu C; University of Southern California, California, CA, USA., Iacono WG; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Centre for Genomic Health, Queen Mary University of London, London, EC1M 6BQ, UK., Kapoor M; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Kardia SL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK., Kontto J; Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington School of Medicine, Seattle, WA, USA., Kuulasmaa K; Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland., Laakso M; University of Eastern Finland, Finland, Finland., Lai D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Le N; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA., Lettre G; Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada., Loukola A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Madden PAF; Department of Psychiatry, Washington University, St. Louis, MO, USA., Mangino M; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK.; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK., Marioni RE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Centre for Genomic Health, Queen Mary University of London, London, EC1M 6BQ, UK., Marten J; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Martin NG; Queensland Institute for Medical Research, Brisbane, Australia., McGue M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Michailidou K; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, 1683, Nicosia, Cyprus., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Moayyeri A; Institute of Health Informatics, University College London, London, UK., Moitry M; Department of Epidemiology and Public health, University Hospital of Strasbourg, Strasbourg, France., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Naheed A; Initiative for Noncommunicable Diseases, Health Systems and Population Studies Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany., Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK., Nielsen SF; Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 74, DK-2730, Herlev, Denmark., North K; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Perola M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland., Pharoah PDP; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK., Pistis G; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy., Polderman TJ; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.; Department of Clinical Genetics, VU University Medical Centre Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands., Poulter N; International Centre for Circulatory Health, Imperial College London, London, UK., Qaiser B; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Reiner A; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Renström F; Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden.; Department of Biobank Research, Umeå University, SE-901 87, Umeå, Sweden., Rice J; Departments of Psychiatry and Mathematics, Washington University St. Louis, St. Louis, MO, USA., Rohde R; University of North Carolina, Chapel Hill, NC, USA., Rolandsson O; Department of Public Health & Clinical Medicine, Section for Family Medicine, Umeå universitet, SE, 90185, Umeå, Sweden., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK., Samuel M; Centre for Non-Communicable Diseases, Karachi, Pakistan., Schlessinger D; National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Scholte SH; Department of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Sever P; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; International Centre for Circulatory Health, Imperial College London, London, UK., Shao Y; University of North Carolina, Chapel Hill, NC, USA., Shrine N; Department of Health Sciences, University of Leicester, Leicester, UK., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Stirrups K; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK., Stram D; Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Tachmazidou I; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Tardif JC; Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Tindle HA; Department of Medicine, Vanderbilt University, Nashville, TN, USA., Tragante V; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, 3508GA, Utrecht, The Netherlands., Trompet S; Department of gerontology and geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of cardiology, Leiden University Medical Center, Leiden, The Netherlands., Turcot V; Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada., Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK., Vaartjes I; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands.; Center for Circulatory Health, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands., van der Leij AR; Department of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands., van der Meer P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Varga TV; Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 301 Binney Street, Cambridge, MA, 02142, USA., Völzke H; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Weiss S; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, 17475, Greifswald, Germany., Wetherill L; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK., Yavas E; Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.; Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, PA, 16802, USA., Jiang Y; Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA., Chen F; Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA., Zhan X; Department of Clinical Science, Center for Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Zhao W; Department of Biostatistics and Epidemiology, University of Pennsylvania, Pennsylvania, PA, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhou K; School of Medicine, University of Dundee, Dundee, UK., Amouyel P; Department of Epidemiology and Public Health, Institut Pasteur de Lille, Lille, France., Blankenberg S; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.; University Medical Center Hamburg Eppendorf, Hamburg, Germany., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Chowdhury R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Deloukas P; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Di Angelantonio E; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Ferrario M; EPIMED Research Centre, Department of Medicine and Surgery, University of Insubria at Varese, Varese, Italy., Ferrières J; Department of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France., Franks PW; Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden.; Department of Nutrition, Harvard T. H. 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Publikováno v: Molecular psychiatry [Mol Psychiatry] 2020 Oct; Vol. 25 (10), pp. 2392-2409. Date of Electronic Publication: 2019 Jan 07.

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