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pro vyhledávání: '"Qabil, Zahari"'
Autor:
Bernadette, Carroll, Glyn, Nelson, Yoana, Rabanal-Ruiz, Olena, Kucheryavenko, Natasha A, Dunhill-Turner, Charlotte C, Chesterman, Qabil, Zahari, Tong, Zhang, Sarah E, Conduit, Christina A, Mitchell, Oliver D K, Maddocks, Penny, Lovat, Thomas, von Zglinicki, Viktor I, Korolchuk
Publikováno v:
The Journal of Cell Biology
It is unclear how mTORC1 signaling differs in senescent and young cells. Carroll et al. show that senescence leads to constitutive mTORC1 activation and resistance to serum and amino acid starvation. This is associated with elevated autophagy, depola