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Akademický článek

Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure

Autor: Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-Fan Hu, Tao Li

Publikováno v: International Journal of Hepatology, Vol 2016 (2016)

Human umbilical cord-derived mesenchymal stem cells (UCMSCs) are particularly attractive cells for cellular and gene therapy in acute liver failure (ALF). However, the efficacy of this cell therapy in animal studies needs to be significantly improved

Externí odkaz: https://doaj.org/article/d9bedf2e1ab6455381c714607e5710cf

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PLAC1-specific TCR-engineered T cells mediate antigen-specific antitumor effects in breast cancer

Autor: Youfu Wang, Man Wu, Xiaoping Zeng, Xin Zhou, Shaobin Wang, Hu Yuan, Liu Weibin, Yixin He, Xiang Hu, Junhui Chen, Dong Xiao, Liu Qubo, Qiongshu Li, Liu Muyun

Publikováno v: Oncology Letters.

Placenta-specific 1 (PLAC1), a novel cancer-testis antigen (CTA), is expressed in a number of different human malignancies. It is frequently produced in breast cancer, serving a function in tumorigenesis. Adoptive immunotherapy using T cell receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec9a55525c7b85f4d61152de39a2fb5
https://doi.org/10.3892/ol.2018.8075

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Human Umbilical Cord Mesenchymal Stem Cells Suppress Systemic Lupus Erythematosus Lesions by Rebalancing CD4+/CD8+ Cell Population

Autor: Hu Xiang, Xin Zhou, Jiuwei Cui, Qiongshu Li, Xiaoping Zeng, Li Tao, Wu Chunfeng, Hongfang Ju, Wei Li, Zeng Guifang, Jia Liu, Tenglong Yan, Ji-Fan Hu, Yixin He, Chan Li

Publikováno v: Studies on Stem Cells Research and Therapy. 1:004-011

Despite considerable advances in the treatment for systemic lupus erythematosus (SLE), there is still an unmet need to develop novel therapeutic approaches with improved efficacy and lower side effects. Here we explore human umbilical cord-derived me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7a8e971fe85efdd08a2a52ca8608205
https://doi.org/10.17352/sscrt.000003

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Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways

Autor: Weihua Ni, Qiongshu Li, Fengli Wang, Yingying Guo, Juan Wang, Nannan Zhang, Hongyan Yuan, Ruiping Zhai, Fang Wang, Tanxiu Chen, Fei Xie, Guixiang Tai

Publikováno v: Molecular Medicine Reports

Mucin 1 (MUC1) is an oncogene that has a crucial role in the pathogenesis and progression of the majority of epithelial malignant tumors. Our previous study demonstrated that MUC1 gene silencing inhibited the growth of SMMC-7721 cells in vitro and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe3adf396b10df0e389cf4ad34ae91d
https://doi.org/10.3892/mmr.2015.4323

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Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions

Autor: Fang Wang, Guixiang Tai, Qiongshu Li, Ruiping Zhai, Guomu Liu, Nannan Zhang, Yingying Guo, Hongyan Yuan, Tanxiu Chen, Fei Xie, Weihua Ni, Juan Wang

Publikováno v: Scopus-Elsevier
Oncotarget

Mucin1 (MUC1), as an oncogene, plays a key role in the progression and tumorigenesis of many human adenocarcinomas. In this study, wound-healing, transwell migration and matrigel invasion assays showed that MUC1 promotes human hepatocellular carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307ff99e85d8087e88667f3dfab64ba4
https://doi.org/10.18632/oncotarget.4267

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Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21WAF1 pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells

Autor: Ruiping Zhai, Yingying Guo, Weihua Ni, Guixiang Tai, Hongyan Yuan, Dan Shao, Qiongshu Li, Juan Wang, Tanxiu Chen, Guomu Liu

Publikováno v: Oncotarget

// Qiongshu Li 1 , Guomu Liu 1 , Hongyan Yuan 1 , Juan Wang 1 , Yingying Guo 1 , Tanxiu Chen 1 , Ruiping Zhai 1 , Dan Shao 1 , Weihua Ni 1 , Guixiang Tai 1 1 Department of Immunology, College of Basic Medical Science, Jilin University, Changchun 1300

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f811aee646df797186f9b53b031ccc87
https://doi.org/10.18632/oncotarget.2973

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Usnic acid induces apoptosis via an ROS-dependent mitochondrial pathway in human breast cancer cells in vitro and in vivo

Autor: Yan Zhang, Xue-dong Fang, Shu-ting Zuo, Dan-ning Zhao, Qiongshu Li, Liping Wang, Dan Shao

Publikováno v: RSC Advances. 5:153-162

Usnic acid (UA), an active dibenzofuran derivative mainly found in lichens, is considered an antineoplastic agent based on its activity against tumor cells. However, the exact molecular mechanism through which UA mediates this activity has yet to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e8134c7d0d941bdef3aed3dedadcb96
https://doi.org/10.1039/c4ra12340a

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Escherichia coli maltose-binding protein activates mouse peritoneal macrophages and induces M1 polarization via TLR2/4 in vivo and in vitro

Autor: Qiongshu Li, Fei Xie, Qingyong Zhang, Hongyan Yuan, Yingying Guo, Guomu Liu, Weihua Ni, Fang Wang, Guixiang Tai, Xu Zhang

Publikováno v: International Immunopharmacology. 21:171-180

Maltose-binding protein (MBP) is a component of the maltose transport system of Escherichia coli. Our previous study found that MBP combined with Bacillus Calmette-Guerin (BCG) increases the percentage of activated macrophages in the spleen and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7005bbebe29725a5461f01f3a2e7f758
https://doi.org/10.1016/j.intimp.2014.04.025

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MUC1 and maltose-binding protein recombinant fusion protein combined with Bacillus Calmette-Guerin induces MUC1-specific and nonspecific anti-tumor immunity in mice

Autor: Guixiang Tai, Fei Xie, Juan Wang, Xiaxia Sun, Weihua Ni, Qiongshu Li, Zhonghui Liu, Fengli Wang, Ruiping Zhai, Yingying Li, Jichun Ma, Sunjun Gao, Fang Fang

Publikováno v: Molecular Medicine Reports. 10:1056-1064

Human mucin 1 (MUC1) is a target for immunotherapy. The major problem associated with MUC1‑based cancer vaccines is the weakness of the immunogenicity of MUC1. The present study aimed to develop an efficient cancer vaccine through generating a reco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c4a948acfaa1972f913f183d14c5a0
https://doi.org/10.3892/mmr.2014.2306

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Expression of human full-length MUC1 inhibits the proliferation and migration of a B16 mouse melanoma cell line

Autor: Qiongshu Li, Fengli Wang, Xiaxia Sun, Fang Wang, Fei Xie, Weihua Ni, Juan Wang, Fang Fang, Sujun Gao, Guixiang Tai

Publikováno v: Oncology Reports. 30:260-268

Mucin 1 (MUC1) is a large transmembrane glycoprotein that is aberrantly overexpressed in most adenocarcinomas and certain hematological malignancies. MUC1 is known to function as an oncogene with roles in both tumor formation and progression, making

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5971ae351e867240c25868051a5cca4f
https://doi.org/10.3892/or.2013.2440

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