Zobrazeno 1 - 10
of 1 866
pro vyhledávání: '"QIN Jin"'
Autor:
Weikai Ge, Shixue Gou, Xiaozhu Zhao, Qin Jin, Zhenpeng Zhuang, Yu Zhao, Yanhui Liang, Zhen Ouyang, Xiaoyi Liu, Fangbing Chen, Hui Shi, Haizhao Yan, Han Wu, Liangxue Lai, Kepin Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene therapy. However, there are concerns about the safety of this system, specifically related to the use of guide-free Cas9. Previous studies have
Externí odkaz:
https://doaj.org/article/d5821f95cdce4ed0a2e9fbac9fb1c3f0
Autor:
Hui Shi, Lei Li, Shuangshuang Mu, Shixue Gou, Xiaoyi Liu, Fangbing Chen, Menglong Chen, Qin Jin, Liangxue Lai, Kepin Wang
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency and decreasing byproducts, which proved to be challenging. Results Here, we have developed a human exonuclea
Externí odkaz:
https://doaj.org/article/63f8d4db211341e188077f960aa406ff
Autor:
Shuangshuang Mu, Huangyao Chen, Qianru Li, Shixue Gou, Xiaoyi Liu, Junwei Wang, Wei Zheng, Menglong Chen, Qin Jin, Liangxue Lai, Kepin Wang, Hui Shi
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates. However, the large size of prime editors (PEs) ham
Externí odkaz:
https://doaj.org/article/5d0ea2f60dda49b2aa237e960f70f26e
Publikováno v:
Animal Research and One Health, Vol 1, Iss 2, Pp 242-258 (2023)
Abstract Conditional gene regulation systems can control gene expression in predefined tissues or organs at a desired time. Site‐specific recombinase systems and chemically induced gene expression systems are the two most widely used approaches for
Externí odkaz:
https://doaj.org/article/a5c0fb3a277e441d985f364e2995080e
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-23 (2023)
Abstract Background Hepatocellular carcinoma (HCC) is a primary liver malignancy that is now relatively common worldwide. TMEM79 has been reported to play diagnostic and prognostic markers in a variety of cancers and was found to be closely associate
Externí odkaz:
https://doaj.org/article/da064235b74f428c8d6d5eccfca68729
Autor:
Weikai Ge, Xiaozhu Zhao, Shixue Gou, Qin Jin, Fangbing Chen, Zhen Ouyang, Chengdan Lai, Tao Cui, Baoyi Mai, Sijia Lu, Kexin Zhong, Yanhui Liang, Tao Chen, Han Wu, Nan Li, Yinghua Ye, Liangxue Lai, Kepin Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102035- (2023)
Cas9 protein without sgRNAs can induce genomic damage at the cellular level in vitro. However, whether the detrimental effects occur in embryos after Cas9 treatment remains unknown. Here, using pig embryos as subjects, we observed that Cas9 protein t
Externí odkaz:
https://doaj.org/article/bbe5b6b43aba40698fb60acc055ce682
Autor:
Qin Jin, Xiaoyi Liu, Zhenpeng Zhuang, Jiayuan Huang, Shixue Gou, Hui Shi, Yu Zhao, Zhen Ouyang, Zhaoming Liu, Lei Li, Junjie Mao, Weikai Ge, Fangbing Chen, Manya Yu, Yezhi Guan, Yinghua Ye, Chengcheng Tang, Ren Huang, Kepin Wang, Liangxue Lai
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background CRISPR-based toolkits have dramatically increased the ease of genome and epigenome editing. SpCas9 is the most widely used nuclease. However, the difficulty of delivering SpCas9 and inability to modulate its expression in vivo hin
Externí odkaz:
https://doaj.org/article/110960d35b9b427bbaadfb937e744aa5
Autor:
Yun Zhang, Qi Lu, Qin Jin, Wanting Meng, Shuhu Yang, Shen Huang, Yanling Han, Zhonghua Hong, Zhansheng Chen, Weiliang Liu
Publikováno v:
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, Vol 16, Pp 841-852 (2023)
Cyclone Global Navigation Satellite System (CYGNSS) launched in recent years, provides a large amount of spaceborne GNSS Reflectometry data with all-weather, global coverage, high space-time resolution, and multiple signal sources, which provides new
Externí odkaz:
https://doaj.org/article/b3d742e7bf3c4ac3959dd18c300ffb61
Autor:
Fangbing Chen, Meng Lian, Bingxiu Ma, Shixue Gou, Xian Luo, Kaiming Yang, Hui Shi, Jingke Xie, Weika Ge, Zhen Ouyang, Chengdan Lai, Nan Li, Quanjun Zhang, Qin Jin, Yanhui Liang, Tao Chen, Jiaowei Wang, Xiaozhu Zhao, Lei Li, Manya Yu, Yinghua Ye, Kepin Wang, Han Wu, Liangxue Lai
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Cas12a-mediated cytosine (CBE) and adenine base editor (ABE) systems with elevated efficiencies and expanded target scopes are developed, by combining highly active deaminases with Cas12a variants, enCas12a, RR and RVR, recognizing non-TTTV PAMs.
Externí odkaz:
https://doaj.org/article/a070b51af0f64766bd9a718411c97efb
Autor:
Ludan Ruan, Qin Jin
Publikováno v:
AI Open, Vol 3, Iss , Pp 1-13 (2022)
Inspired by the success of transformer-based pre-training methods on natural language tasks and further computer vision tasks, researchers have started to apply transformer to video processing. This survey aims to provide a comprehensive overview of
Externí odkaz:
https://doaj.org/article/ad80e6226fa74c76b36135f76b25b772