Acetylation stabilises calmodulin‐regulated calcium signalling

Autor: Karen Baker, Michael Geeves, Daniel Mulvihill

Publikováno v: FEBS Letters. 596:762-771

Calmodulin is a conserved calcium signalling protein that regulates a wide range of cellular functions. Amino-terminal acetylation is a ubiquitous post-translational modification that affects the majority of human proteins, to stabilise structure, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d15650e58876f47ee91152b91b0b81
https://doi.org/10.1002/1873-3468.14304

Structural Basis of β2 Integrin Inside-Out Activation

Autor: Lai Wen, Qingkang Lyu, Klaus Ley, Benjamin T. Goult

Publikováno v: Cells. 11(19)

β2 integrins are expressed on all leukocytes. Precise regulation of the β2 integrin is critical for leukocyte adhesion and trafficking. In neutrophils, β2 integrins participate in slow rolling. When activated by inside–out signaling, fully activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6413051971a1c3c0cceb5f96a3b345a3
https://pubmed.ncbi.nlm.nih.gov/36231001

The MeshCODE to scale – Visualising synaptic binary information

Autor: Samuel F H Barnett, Benjamin T Goult

Publikováno v: BioRxiv

The Mercator projection map of the world provides a useful, but distorted, view of the relative scale of countries. Current cellular models suffer from a similar distortion. Here, we undertook an in-depth structural analysis of the molecular dimensio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35191b7ce4146bb665c8e1747fee5f3
https://kar.kent.ac.uk/95486/1/2022_Barnett_BioRxiv.pdf

Myosin-X and talin modulate integrin activity at filopodia tips

Autor: Guillaume Jacquemet, Mitro Miihkinen, Eija Jokitalo, Johanna Ivaska, Helena Vihinen, Benjamin T. Goult, Max L.B. Grönloh

Publikováno v: Cell Reports
Cell Reports, Vol 36, Iss 11, Pp 109716-(2021)

Summary Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined. Here, we report that active integrins accumulate at the tip of myosin-X (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aac38f64c4800b48c76cc3d09ea0a8c
https://kar.kent.ac.uk/81141/13/1-s2.0-S2211124721011657-main.pdf

Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome

Autor: Lee Larcombe, Alexander Suh, Yu Sun, Simone Immler, Mette M. Mogensen, Matthew J. Neale, Rebecca E. O’Connor, Ben Skinner, Peter J. I. Ellis, Claudia Cattoni Rathje, Raheleh Rahbari, Alison C Tidy, Ned Peel, D. S. Murray, Iain C. Macaulay, Christian S. Ottolini, Will Nash, Wilfried Haerty, Michael C. Summers, Tarang K. Mehta, Roberta Bergero, Luke Ramsey

Publikováno v: Biological Reviews of the Cambridge Philosophical Society
Bergero, R, Ellis, P, Haerty, W, Larcombe, L, Macaulay, I, Mehta, T, Mogensen, M, Murray, D, Nash, W, Neale, M J, O'Connor, R, Ottolini, C, Peel, N, Ramsey, L, Skinner, B, Suh, A, Summers, M, Sun, Y, Tidy, A, Rahbari, R, Rathje, C & Immler, S 2021, ' Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome ', Biological reviews, vol. 96, no. 3, pp. 822-841 . https://doi.org/10.1111/brv.12680

The separation of germ cell populations from the soma is part of the evolutionary transition to multicellularity. Only genetic information present in the germ cells will be inherited by future generations, and any molecular processes affecting the ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5013a65174293a5982c544ce7554251c