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Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates

Autor: Damian Plażuk, Karolina Kowalczyk, Andrzej Błauż, Homayon J. Arabshahi, Anna Makal, Chatchakorn Eurtivong, Jóhannes Reynisson, Anna Wieczorek-Błauż, Błażej Rychlik, Sylwia Pawlędzio, Christian G. Hartinger

Publikováno v: Dalton Transactions. 51:491-508

The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol - the first low molecular weight kinesin spin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1ecbb5a3fdc4d6e32b576e1271a968
https://doi.org/10.1039/d1dt03553c

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Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy

Autor: D. P. Tonge, D. Darling, F. Farzaneh, G. T. Williams

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports

Identification of cell fate-controlling lncRNAs is essential to our understanding of molecular cell biology. Here we present a human genome-scale forward-genetics approach for the identification of lncRNAs based on gene function. This approach can id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6bfec4912b9ce56fe8e2c7dec32833
https://doaj.org/article/b708f93f4bf84c4fa8dcdf15e0a97bc0

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Defects in MgB4O7 (pure and doped with lanthanides): A case study using a computational modelling approach

Autor: Giordano F.C. Bispo, Débora S. Nascimento, Lucas B. Santana, Gilvan S. Ferreira, Zélia S. Macedo, Hestia R.B.R. Lima, Susana O. Souza, Francesco d'Errico, Robert A. Jackson, Mário E.G. Valerio

Lanthanide-doped MgB4O7 is a potential dosimetric material due to its thermoluminescence (TL) and optically stimulated luminescence (OSL) properties. These properties have been largely reported, but there are few theoretical studies dedicated to unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102bac89db61fc2a784880ff0868b6a8
https://eprints.keele.ac.uk/10978/1/SSRN-id4022366.pdf

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Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins

Autor: Ryan McBerney, Jonathan P. Dolan, Emma E. Cawood, Michael E. Webb, W. Bruce Turnbull

Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms. Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd53d7e8f2c4d5cea785b0bb780a390a
https://eprints.keele.ac.uk/11467/1/jacsau.2c00312.pdf

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Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways

Autor: M. A. Lima, T. R. Rudd, D. G. Fernig, E. A. Yates

Publikováno v: interface

Phosphate and sulfate groups are integral to energy metabolism and introduce negative charges into biological macromolecules. One purpose of such modifications is to elicit precise binding/activation of protein partners. The physico-chemical properti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093435f9cbf94812e1b80489215df4db
https://pubmed.ncbi.nlm.nih.gov/35919982

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Molecular Inhibition for Selective CO 2 Conversion

Autor: Charles E. Creissen, José Guillermo Rivera de la Cruz, Dilan Karapinar, Dario Taverna, Moritz W. Schreiber, Marc Fontecave

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2022, 61 (32), ⟨10.1002/anie.202206279⟩
chemrxiv

International audience; Electrochemical CO2 reduction presents a sustainable route to the production of chemicals and fuels. Achieving a narrow product distribution with heterogeneous Cu catalysts is challenging and conventional material modification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b58094c695bcc462561e8acc9d7c0b
https://doi.org/10.1002/anie.202206279

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Chronic Atmospheric Reactive Nitrogen Deposition Suppresses Biological Nitrogen Fixation in Peatlands

Autor: Falko P. Drijfhout, Fotis Sgouridis, Ernesto Saiz, Sami Ullah, Mats Nilsson, Matthias Peichl

Publikováno v: Saiz, E, Sgouridis, F, Drijfhout, F P, Peichl, M, Nilsson, M B & Ullah, S 2021, ' Chronic Atmospheric Reactive Nitrogen Deposition Suppresses Biological Nitrogen Fixation in Peatlands ', Environmental Science and Technology, vol. 55, no. 2, pp. 1310-1318 . https://doi.org/10.1021/acs.est.0c04882

Biological nitrogen fixation (BNF) represents the natural pathway by which mosses meet their demands for bioavailable/reactive nitrogen (Nr) in peatlands. However, following intensification of nitrogen fertilizer and fossil fuel use, atmospheric Nr d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d7c4c367057fbdfc81545efbcecc21
https://doi.org/10.1021/acs.est.0c04882

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The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme

Autor: Sine Larsen, M. Haertlein, J. Ramos, E. Mossou, V. Laux, V.T. Forsyth, Annette Eva Langkilde

Publikováno v: 'Acta Crystallographica D ', vol: 77, pages: 1579-1590 (2021)
Ramos, J, Laux, V, Haertlein, M, Forsyth, V T, Mossou, E, Larsen, S & Langkilde, A E 2021, ' The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme ', Acta crystallographica Section D: Structural biology, vol. 77, no. 12, pp. 1579-1590 . https://doi.org/10.1107/S2059798321010950
Acta Crystallographica. Section D, Structural Biology

A study of in vitro refolding and isotope effects on protein structure, activity and stability shows that different folding dynamics can lead to important changes in protein properties.
The biological function of a protein is intimately related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082ff1ad2dc9755439d789a6869b8a3d
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ILL:31577

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Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions

Autor: V. Trevor Forsyth, Anne Imberty, Matthew P. Blakeley, Michael Haertlein, Lukas Gajdos, Michaela Wimmerová, Juliette M. Devos, Atul Kumar

Publikováno v: 'Structure ', vol: 29, pages: 1003-1013 (2021)
Structure
Structure, Elsevier (Cell Press), 2021, ⟨10.1016/j.str.2021.03.003⟩

Summary Carbohydrate-binding proteins from pathogenic bacteria and fungi have been shown to be implicated in various pathological processes, where they interact with glycans present on the surface of the host cells. These interactions are part of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecdc55020ca6280084791a690289963
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ILL:31174

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COVID-19 and the ethnicity link – is there a photochemical link?

Autor: Edge, Ruth, Truscott, T. George

Publikováno v: Edge, R & Truscott, T G 2022, ' COVID-19 and the ethnicity link – is there a photochemical link? ', Photochemical & Photobiological Sciences, vol. 20, no. 1, pp. 183-188 . https://doi.org/10.1007/s43630-020-00004-8
Photochemical & Photobiological Sciences

A hypothesis is proposed to explain the increased detrimental effect of COVID-19 for Black, Asian and Minority Ethnic (BAME) men and women compared to Caucasian individuals. This is based on the differing photochemistry of phaeomelanin in fair skin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7bb66f315e922c9ea802b40192e8c7
https://doi.org/10.1007/s43630-020-00004-8

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