Zobrazeno 1 - 10
of 14
pro vyhledávání: '"QD0411"'
Autor:
Andrew C. Runcie, T. Krojer, Jordan Doyle, Sarah Picaud, Oleg Fedorov, John Spencer, Rebecca Banks, Alessio Ciulli, Panagis Filippakopoulos, Cory A. Ocasio, Timothy Chevassut, Helen Stewart, Carol Austin, Hannah J. Maple, Robert Felix, Storm Hassell-Hart, Simon J. Morley, Ella Lineham, Brenno A. D. Neto, Graham P. Marsh, Paul Brennan, Martin Walker, Frank von Delft
Publikováno v:
Organometallics.
(+)-JD1, a rationally designed ferrocene analogue of the BET bromodomain (BRD) probe molecule (+)-JQ1, has been synthesized and evaluated in biophysical, cell-based assays as well as in pharmacokinetic studies. It displays nanomolar activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792b39304fc33cbed41e4926cf7ff7ad
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Molloy, Matthew K
The introductory chapter of this thesis shall discuss the structure, binding modes and practical application of the pentalene ligand in organometallic chemistry. The synthesis and properties of the bimetallic titanium pentalene compound [Ti(μ:η5,η
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6de0023c9ae905fa27a3adadb9015d30
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 48(23)
A homologous series of novel trans-cyaphide–alkynyl complexes, viz. trans-[Ru(dppe)2(CP)(CCC6H4R-p)] (R = Me, H, F, CO2Me, NO2) is prepared and comprehensively characterised, alongside their parent phosphaalkyne-complex cations trans-[Ru(dppe)2(η1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be042ed663c9c6a00378c139c4f1aad
https://pubmed.ncbi.nlm.nih.gov/31414091
https://pubmed.ncbi.nlm.nih.gov/31414091
Autor:
Leech, Matthew Christopher
This thesis describes the synthesis, characterisation, and electrochemical behaviour of a series of transition metal cyaphide complexes, with the aim of understanding how the introduction of low-coordinate phosphorus fragments into through-conjugated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::dd05dc291301b932e6d6038f89816bbf
Autor:
Eddy M. E. Viseux, Fatai Afolabi, Clement Lemaitre, Neil Crickmore, Guillaume Riviere, Wided Souissi, Mark Roe
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 47(43)
A new series of cationic gold(I) pyrazole complexes were prepared in excellent yields as their perchlorate salts. Results of cell viability assays show that these novel complexes have good cytotoxic properties against the human HepG2 cancer cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b87156ee60a05d1cabd1efd2f1df97
https://pubmed.ncbi.nlm.nih.gov/30276377
https://pubmed.ncbi.nlm.nih.gov/30276377
Autor:
Ansell, Melvyn B, Furfari, Samantha K, Cloke, F Geofffrey N, Roe, S Mark, Spencer, John, Navarro, Oscar
The novel Pd(0)-azobenzene complex (ITMe)2Pd(PhN=NPh) (5) (ITMe = 1,3,4,5-tetramethylimidazol 2-ylidene) has been isolated and characterized in the solid state and by cyclic voltammetry. Its reactivity towards E-E’ bonds (E, E’= Si, B, Ge) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f352fd1535b68c94a8c78b6196f06635
http://sro.sussex.ac.uk/id/eprint/74606/3/acs.organomet.8b00112.pdf
http://sro.sussex.ac.uk/id/eprint/74606/3/acs.organomet.8b00112.pdf
Autor:
Sansook, S, Ocasio, CA, Day, IJ, Tizzard, GJ, Coles, SJ, Fedorov, O, Bennett, JM, Elkins, JM, Spencer, J
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6- pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9b40a506f58f77e092b5619291a95c78
https://ora.ox.ac.uk/objects/uuid:f5dac73d-3082-4f67-a166-1a69d1f48072
https://ora.ox.ac.uk/objects/uuid:f5dac73d-3082-4f67-a166-1a69d1f48072
Autor:
Nikolaos Tsoureas, Simon J. Coles, Graham J. Tizzard, Rhiannon N. Jones, Thomas G. Scott, James E. Bradner, Cory A. Ocasio, Peter Coxhead, James Spencer, Justin M. Roberts, Supojjanee Sansook, Helfrid Hochegger, Matthew Guille
Publikováno v:
Ocasio, C A, Sansook, S, Jones, R, Roberts, J M, Scott, T G, Tsoureas, N, Coxhead, P, Guille, M, Tizzard, G J, Coles, S J, Hochegger, H, Bradner, J E & Spencer, J 2017, ' Pojamide : an HDAC3-selective ferrocene analogue with remarkably enhanced redox-triggered ferrocenium activity in cells ', Organometallics . https://doi.org/10.1021/acs.organomet.7b00437
A ferrocene containing o-aminoanilide, N1-(2-aminophenyl)-N8-ferrocenyloctanediamide (2b, Pojamide) displayed nanomolar potency vs HDAC3. In comparison to RGFP966, a potent and selective HDAC3 inhibitor, Pojamide displayed superior activity in HCT116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3740e6c7b657bbf89c178144ecc0e6e
https://eprints.soton.ac.uk/413525/
https://eprints.soton.ac.uk/413525/
Autor:
Boonseng, Sarote
This thesis presents a detailed theoretical/computational analysis using quantum chemistry to investigate the thermochemistry and reaction mechanisms of palladacycles that underpin experimental observations. The thesis begins by establishing a suitab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9f33dd95f9ffec9145ff3e8f84731002