Resistance-associated polymorphisms in Dutch hepatitis C genotype 1a patients with and without HIV infection

Autor: Faydra I. Lieveld, Niels Swaans, Astrid M. Newsum, Cynthia K.Y. Ho, Janke Schinkel, Richard Molenkamp, Jan T.M. van der Meer, Joop E. Arends, Andy I.M. Hoepelman, Anne M.J. Wensing, Peter D. Siersema, Karel J. van Erpecum, Greet J. Boland

Publikováno v: Annals of Hepatology, Vol 15, Iss 5, Pp 696-704 (2016)

Background and aim. Resistance-associated variants (RAVs) on the NS3 region of the hepatitis C virus (HCV) may be relevant for antiviral therapy, but data in human immunodeficiency virus (HIV) coinfected patients are scarce. We assessed frequencies o

Externí odkaz: https://doaj.org/article/ef7f7c7b6ddf4c0f9a907447d000c29e

Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Autor: Popping, Stephanie, Verwijs, R, Cuypers, L, Claassen, Mark, van den Berk, GE, De Weggheleire, A, Arends, JEA, Boerekamps, Anne, Molenkamp, Richard, Koopmans, Marion, Verbon, Annelies, Boucher, Charles, Rijnders, Bart, Vijver, David, Lauw, F, Posthouwer, D, Hullegie, S, Bierman, W, Dofferhof, A, Kootstra, GJ, Leyten, E, Hollander, Jessica, van Kasteren, M, Soutekouw, R, Ammerlaan, H, Florence, E

Publikováno v: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases, 71(8), E215-E217. Oxford University Press

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6daaef0cbc11e409346fdd4f69536859
https://lirias.kuleuven.be/handle/20.500.12942/707615

Effects of the Q80K Polymorphism on the Physicochemical Properties of Hepatitis C Virus Subtype 1a NS3 Protease

Autor: Deborah Antunes, André Q. Torres, Elisabeth Lampe, Allan Peres-da-Silva, Ernesto Raul Caffarena

Publikováno v: Viruses, Vol 11, Iss 8, p 691 (2019)
Viruses
Volume 11
Issue 8

Hepatitis C virus genotype 1a (HCV-1a) comprises clades I and II. The Q80K polymorphism is found predominantly in clade I but rarely in clade II. Here, we investigated whether natural polymorphisms in HCV-1a clade II entailed structural protein chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d65cd7366d409532615c35ab0db739
https://www.mdpi.com/1999-4915/11/8/691

Evaluation of a commercial real-time PCR kit for the detection of the Q80K polymorphism in plasma from HCV genotype 1a infected patients

Autor: Bianca Bruzzone, Ilaria Vicenti, Ombretta Turriziani, Maurizio Zazzi, Laura Sticchi, Francesca Falasca

Publikováno v: Journal of Clinical Virology. 76:20-23

Background Screening of the natural HCV NS3 polymorphism Q80K is required prior to simeprevir administration due to the reduced susceptibility of genotype 1 viruses carrying this amino acid variant. A simple, rapid and robust test for Q80K screening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bb4d4f2d02f03cd439b982495190ed
https://doi.org/10.1016/j.jcv.2016.01.006

Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy

Autor: Kileng, Hege, Kjellin, Midori, Akaberi, Dario, Bergfors, Assar, Duberg, Ann-Sofi, Wesslen, Lars, Danielsson, Astrid, Kristiansen, Magnhild Gangsøy, Gutteberg, Tore Jarl, Goll, Rasmus, Lannergård, Anders, Lennerstrand, Johan

Publikováno v: Kileng, H.K., Kjellin, M., Akaberi, D., Bergfors, A., Duberg, A-S., Wesslèn, L. ... Lennerstrand, J. (2018). Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy. Scandinavian Jo