Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Q. May Wang"'
Autor:
John E. Munroe, Q. May Wang, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Robert B. Johnson, Guo Deqi, Beverly A. Heinz, Jason Eric Lamar, Joseph M. Colacino, John I. Glass, Yip Yvonne Yee Mai
Publikováno v:
Letters in Drug Design & Discovery. 2:118-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26be57b77d8fdb1284a536e0ce97f6a2
https://doi.org/10.2174/1570180053175115
https://doi.org/10.2174/1570180053175115
Publikováno v:
Chemistry - A European Journal. 10:173-181
A convergent strategy for the synthesis of cyclic nucleotide-hybrid molecules on controlled pore glass is reported. A major advantage of the approach is the lack of restrictions on the sequence and structural variation, allowing the incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8738272da48cebb5035527afb180fb9c
https://doi.org/10.1002/chem.200305402
https://doi.org/10.1002/chem.200305402
Autor:
Q. May Wang, John I. Glass, Yip Yvonne Yee Mai, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Robert B. Johnson, Nancy June Snyder, Guo Deqi, Jason Eric Lamar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:257-261
With the aim of discovering potent and selective HCV protease inhibitors, we synthesized and evaluated a series of 1a based tetrapeptidyl ketoamides with additional modification(s) at P1′, P1, and P3 positions. As a result of this effort, we found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f275bbea4f02e46d25f244e2fcf482cd
https://doi.org/10.1016/j.bmcl.2003.09.075
https://doi.org/10.1016/j.bmcl.2003.09.075
Autor:
Jason Eric Lamar, Ling Jin, Daryl Venable, Lifei Liu, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Q. May Wang, Yip Yvonne Yee Mai, Donna Barket, Robert B. Johnson, Joe Colacino, Mark Wakulchik, John E. Munroe, Beverly A. Heinz, John I. Glass, Congping Xie, Elcira C. Villarreal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:251-256
We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03ae4d6ce258904c379bc3ebcafdec6
https://doi.org/10.1016/j.bmcl.2003.09.074
https://doi.org/10.1016/j.bmcl.2003.09.074
Autor:
Q. May Wang, Beverly A. Heinz, Frantz Victor, Shu-Hui Chen, Robert B. Johnson, Nancy June Snyder, Jason Eric Lamar, Mark Wakulchik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3531-3536
We describe herein the synthesis and biological evaluation of a series of tripeptidyl α-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a823bffbeeb5a9c224e0f7eeb65db0
https://doi.org/10.1016/s0960-894x(03)00753-4
https://doi.org/10.1016/s0960-894x(03)00753-4
Autor:
Vincent J.-P. Lévêque, Stephen Parsons, Congping Xie, Jianxin Ren, Q. May Wang, Faming Zhang, Robert B. Johnson
Publikováno v:
Journal of Virology. 77:9020-9028
The NS5B RNA-dependent RNA polymerase encoded by the hepatitis C virus (HCV) is a key component of the viral replicase. Reported here is the three-dimensional structure of HCV NS5B polymerase, with the highlight on its C-terminal folding, determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e365122d3257b9ae34d24943c39dd963
https://doi.org/10.1128/jvi.77.16.9020-9028.2003
https://doi.org/10.1128/jvi.77.16.9020-9028.2003
Publikováno v:
Biochemical Journal. 363:147-155
Eukaryotic initiation factor 4A (eIF4A) is an ATP-dependent RNA helicase and is homologous to the non-structural protein 3 (NS3) helicase domain encoded by hepatitis C virus (HCV). Reported here is the comparative characterization of human eIF4A and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1104bf2a890a759e0da4dc985912f5
https://doi.org/10.1042/bj3630147
https://doi.org/10.1042/bj3630147
Autor:
Linfang Wang, Q. May Wang, Lu Han, Weiguo Su, Tianwei Zhang, Shiming Fan, Xinying Su, Xiaolu Yin, Yuan Jie Liu, Yongjuan Yu, Jing Lv, Wen Xu, Huiying Wang, Longxian Jiao, Feng Zhou, Yongxin Ren, Weiguo Qing, Liang Xie, Haihua Fu, Shirlian Xu, Paul R. Gavine, Wei Zhang
Publikováno v:
Molecular oncology. 9(1)
Purpose To investigate the incidence of cMET gene copy number changes and protein overexpression in Chinese gastric cancer (GC) and to preclinically test the hypothesis that the novel, potent and selective cMET small-molecule inhibitor volitinib, wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b165b6d141255c47784a2ccff495bd66
https://pubmed.ncbi.nlm.nih.gov/25248999
https://pubmed.ncbi.nlm.nih.gov/25248999
Publikováno v:
Journal of Virology. 74:11121-11128
The RNA-dependent RNA polymerase (RdRp) from hepatitis C virus (HCV), nonstructural protein 5B (NS5B), has recently been shown to direct de novo initiation using a number of complex RNA templates. In this study, we analyzed the features in simple RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca6488c6360a502f3e048d61d2f9021
https://doi.org/10.1128/jvi.74.23.11121-11128.2000
https://doi.org/10.1128/jvi.74.23.11121-11128.2000
Autor:
Robert B. Johnson, Melvin G. Johnson, Mark Wakulchik, Q. May Wang, James A. Cook, Elcira C. Villarreal, Gregory A. Cox
Publikováno v:
Journal of Biological Chemistry. 274:13211-13216
A purified recombinant human rhinovirus-14 3C protease preparation contained only approximately 50% active enzyme as titrated using specifically designed irreversible 3C protease inhibitors. Analysis of the purified 3C protein by isoelectric focusing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96751304732327ff6add8acb4aaa47b
https://doi.org/10.1074/jbc.274.19.13211
https://doi.org/10.1074/jbc.274.19.13211