Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Q Lam"'
Autor:
Sanjit K. Roy, Yiming Ma, Bao Q. Lam, Anju Shrivastava, Sudesh Srivastav, Sharmila Shankar, Rakesh K. Srivastava
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Most cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade apoptosis. However, pancreatic cancer cells switch to glutamine metabolism to survive under hypoxic conditions. Activation of the Wnt/β-catenin pat
Externí odkaz:
https://doaj.org/article/a177ce1f5ce248799726284ca6584e14
Autor:
John P. Brabson, Tiffany Leesang, Yoon Sing Yap, Jingjing Wang, Minh Q. Lam, Byron Fang, Igor Dolgalev, Daniela A. Barbieri, Victoria Strippoli, Carolina P. Bañuelos, Sofia Mohammad, Peter Lyon, Sana Chaudhry, Dane Donich, Anna Swirski, Evan Roberts, Ivelisse Diaz, Daniel Karl, Helena Gomes Dos Santos, Ramin Shiekhattar, Benjamin G. Neel, Stephen D. Nimer, Ramiro E. Verdun, Daniel Bilbao, Maria E. Figueroa, Luisa Cimmino
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112027- (2023)
Summary: TET2 haploinsufficiency is a driving event in myeloid cancers and is associated with a worse prognosis in patients with acute myeloid leukemia (AML). Enhancing residual TET2 activity using vitamin C increases oxidized 5-methylcytosine (mC) f
Externí odkaz:
https://doaj.org/article/5e49692c1c5545df90f0bdb82844b32f
Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma
Autor:
Takahito Sugase, Bao Q. Lam, Meggie Danielson, Mizue Terai, Andrew E. Aplin, J. Silvio Gutkind, Takami Sato
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal models. We previously re
Externí odkaz:
https://doaj.org/article/40fa013f54d94e7fa6ce82bad4dece46
Autor:
Vivian Chua, Marlana Orloff, Jessica LF Teh, Takahito Sugase, Connie Liao, Timothy J Purwin, Bao Q Lam, Mizue Terai, Grazia Ambrosini, Richard D Carvajal, Gary Schwartz, Takami Sato, Andrew E Aplin
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 2, Pp 1-16 (2019)
Abstract Alterations in transcriptional programs promote tumor development and progression and are targetable by bromodomain and extraterminal (BET) protein inhibitors. However, in a multi‐site clinical trial testing the novel BET inhibitor, PLX511
Externí odkaz:
https://doaj.org/article/ad9494b5987a443bb7fdef74004cf81b
Publikováno v:
Cells, Vol 10, Iss 11, p 3077 (2021)
Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a major cause
Externí odkaz:
https://doaj.org/article/c0d58f770f4e40f3aed6e6866b098189
Akademický článek
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Akademický článek
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Top-Down Cognitive and Linguistic Influences on the Suppression of Spontaneous Otoacoustic Emissions
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Auditory sensation is often thought of as a bottom-up process, yet the brain exerts top-down control to affect how and what we hear. We report the discovery that the magnitude of top-down influence varies across individuals as a result of differences
Externí odkaz:
https://doaj.org/article/21bf4bee64e04fee96e11ebf3578c718
Autor:
Ryuji Morizane, Albert Q. Lam
Publikováno v:
Biomarker Insights, Vol 2015, Iss Suppl. 1, Pp 147-152 (2015)
Externí odkaz:
https://doaj.org/article/102e65558882411f93906925d3d321ba
Publikováno v:
Biomarker Insights, Vol 2015, Iss Suppl. 1, Pp 133-137 (2015)
Externí odkaz:
https://doaj.org/article/c0e3232be2ab4941940ae337d22a897d