Detailed evaluation of pyruvate dehydrogenase complex inhibition in simulated exercise conditions

Autor: Michael A. Moxley, Bodhi A. Jelinek

Publikováno v: Biophys J

The mammalian pyruvate dehydrogenase complex (PDC) is a mitochondrial multienzyme complex that connects glycolysis to the tricarboxylic acid cycle by catalyzing pyruvate oxidation to produce acetyl-CoA, NADH, and CO(2). This reaction is required to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5092f2b6f186a0d479010776ba571aef
https://doi.org/10.1016/j.bpj.2021.01.018

Increasing carbohydrate oxidation improves contractile reserves and prevents hypertrophy in porcine right heart failure

Autor: Jakob Lindhardt, Nikolaj Bøgh, Robert S. Stephenson, Per Mose Nielsen, Peter Agger, Esben Søvsø Szocska Hansen, Camilla Omann, Vibeke E. Hjortdal, Christoffer Laustsen

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Bøgh, N, Søvsø Szocska Hansen, E, Omann, C, Lindhardt, J L, Nielsen, P M, Stephenson, R S, Laustsen, C, Hjortdal, V E & Agger, P 2020, ' Increasing carbohydrate oxidation improves contractile reserves and prevents hypertrophy in porcine right heart failure ', Scientific Reports, vol. 10, 8158 . https://doi.org/10.1038/s41598-020-65098-7

In heart failure, myocardial overload causes vast metabolic changes that impair cardiac energy production and contribute to deterioration of contractile function. However, metabolic therapy is not used in heart failure care. We aimed to investigate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89dd7fa11ca4180eae03ef6905129901
http://link.springer.com/article/10.1038/s41598-020-65098-7

Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β-cells causes morphological and functional changes

Autor: Yuanyuan Hu, Xiaochun Bai, Yanshi Ye, Jie Shen, Daoyan Pan, Xiao Wang, Shuchang Lai

Publikováno v: Molecular Medicine Reports

Diabetes mellitus is a metabolic disorder predominantly caused by the dysfunction of pancreatic β‑cells. This dysfunction is partly caused by the dysregulation of pyruvate dehydrogenase (PDH), which acts as an important mediator of pyruvate oxidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4fe92f50b07483b8827fac28c72676
http://europepmc.org/articles/PMC7057776

The neglected foodborne mycotoxin Fusaric acid induces bioenergetic adaptations by switching energy metabolism from mitochondrial processes to glycolysis in a human liver (HepG2) cell line

Autor: Naeem Sheik Abdul, Anil A. Chuturgoon, Savania Nagiah

Publikováno v: Toxicology Letters. 318:74-85

Metabolic flexibility defines the capacity of cells to respond to changes in nutrient status. Mitochondria are important mediators of metabolic flexibility and dysfunction is associated with metabolic inflexibility and pathology. Foodborne toxins are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b987ecd628d1fe67593ceeacd0ffddab
https://doi.org/10.1016/j.toxlet.2019.10.013

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Autor: Ifat Abramovich, Doron Gerber, Matthew D. Hirschey, Olga Ilkayeva, Yael Shahar, Asaf A. Gertler, Asael Roichman, Yair Glick, Noga Touitou, Haim Y. Cohen, Orly Yaron, Matan Y. Avivi, Liat Nahum, Robert A. Harris, Frank K. Huynh, Reuven Gil, Yariv Kanfi, Eyal Gottlieb, Shoshana Naiman, Batia Lerrer, Tirza Doniger

Publikováno v: Cell Reports, Vol 29, Iss 12, Pp 4127-4143.e8 (2019)

Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a0fdd89fedfd6c7785ea89d63a1ca0
http://www.sciencedirect.com/science/article/pii/S221112471931558X