Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice

Autor: Sophie Dennhardt, Wiebke Pirschel, Bianka Wissuwa, Diana Imhof, Christoph Daniel, Jan T. Kielstein, Isabel Hennig-Pauka, Kerstin Amann, Florian Gunzer, Sina M. Coldewey

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Hemolytic-uremic syndrome (HUS) can occur as a systemic complication of infections with Shiga toxin (Stx)-producing Escherichia coli and is characterized by microangiopathic hemolytic anemia and acute kidney injury. Hitherto, therapy has been limited

Externí odkaz: https://doaj.org/article/73c083dc2f7b42d28e80aa2a033b3c87

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Treatment of Mild Traumatic Brain Injury with an Erythropoietin-Mimetic Peptide

Autor: Carla Cerami Hand, Raymond J. Grill, Samson Sujit Kumar Gaddam, H. Julia Hannay, Claudia S. Robertson, Tian Siva Tian, Robert Garcia

Publikováno v: Journal of Neurotrauma. 30:765-774

Mild traumatic brain injury (mTBI) results in an estimated 75–90% of the 1.7 million TBI-related emergency room visits each year. Post-concussion symptoms, which can include impaired memory problems, may persist for prolonged periods of time in a f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6004f55c37e648df7d9949475539d790
https://doi.org/10.1089/neu.2012.2431

Renoprotective capacities of non-erythropoietic EPO derivative, ARA290, following renal ischemia/reperfusion injury

Autor: Gertrude J. Nieuwenhuijs-Moeke, Harry van Goor, Willem G van Rijt, Petra J. Ottens, Henri G. D. Leuvenink, Rutger J. Ploeg

Publikováno v: Journal of translational medicine, 11:286. BioMed Central Ltd.
Journal of Translational Medicine

Background: ARA290 is a non-erythropoietic EPO derivative which only binds to the cytoprotective receptor complex (EPOR2-beta cR(2)) consisting of two EPO-receptors (EPOR) and two beta common receptors (beta cR). ARA290 is renoprotective in renal isc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11192b150ad9099dfb5a8a5b2492766e
https://hdl.handle.net/11370/ff0397cb-6b84-4466-bb2f-6802bef48a61

Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide.

Autor: Heikal L; Brighton and Sussex Medical School, Falmer, Brighton., Ghezzi P; Brighton and Sussex Medical School, Falmer, Brighton., Mengozzi M; Brighton and Sussex Medical School, Falmer, Brighton., Stelmaszczuk B; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital and Institute for Life Sciences, Southampton, UK., Feelisch M; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital and Institute for Life Sciences, Southampton, UK., Ferns GA; Brighton and Sussex Medical School, Falmer, Brighton.

Publikováno v: Hypoxia (Auckland, N.Z.) [Hypoxia (Auckl)] 2016 Aug 16; Vol. 4, pp. 121-133. Date of Electronic Publication: 2016 Aug 16 (Print Publication: 2016).