Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pyrimidinones/therapeutic use"'
Autor:
Fanny Seraphine Krebs, Bianca Moura, Edoardo Missiaglia, Veronica Aedo-Lopez, Olivier Michielin, Petros Tsantoulis, Bettina Bisig, Mounir Trimech, Vincent Zoete, Krisztian Homicsko
Publikováno v:
International journal of molecular sciences, vol. 24, no. 5, pp. 4520
The development of targeted therapies for non-BRAF p.Val600-mutant melanomas remains a challenge. Triple wildtype (TWT) melanomas that lack mutations in BRAF, NRAS, or NF1 form 10% of human melanomas and are heterogeneous in their genomic drivers. MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c2d7b7bfc9703cd98b057de8fcea53
https://serval.unil.ch/notice/serval:BIB_E3A48A3138B7
https://serval.unil.ch/notice/serval:BIB_E3A48A3138B7
Autor:
Veronica Aedo-Lopez, Bettina Bisig, Alexandre Wicky, Olivier Michielin, Mounir Trimech, Camille L. Gerard, Fanny S Krebs, Krisztian Homicsko, Edoardo Missiaglia, Vincent Zoete
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8021, p 8021 (2020)
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 21, pp. E8021
Volume 21
Issue 21
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 21, pp. E8021
Volume 21
Issue 21
We report a case of an uveal melanoma patient with GNAQ p.Gly48Leu who responded to MEK inhibition. At the time of the molecular analysis, the pathogenicity of the mutation was unknown. A tridimensional structural analysis showed that G&alpha
q
q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720d088a79814508b85a7b35f96730d
https://www.mdpi.com/1422-0067/21/21/8021
https://www.mdpi.com/1422-0067/21/21/8021
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 164
We saw a 59-year-old patient who was treated with dabrafenib and trametinib because of metastatic melanoma. She had an asymptomatic, black-blue macula in the excision scar. Histopathology showed tumoral melanosis. This is an histological term for der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::1f1cbe6a328b41a927cc8376aa4a3a10
Publikováno v:
Nederlands tijdschrift voor geneeskunde, 164. Bohn Stafleu van Loghum
We saw a 59-year-old patient who was treated with dabrafenib and trametinib because of metastatic melanoma. She had an asymptomatic, black-blue macula in the excision scar. Histopathology showed tumoral melanosis. This is an histological term for der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::a2973bdb6873a55dde1d4cfd4eba99d3
https://pure.amc.nl/en/publications/een-vrouw-met-een-voor-melanoom-verdachte-plek(fbdd369e-dcd2-45b3-b37a-60af20aa280f).html
https://pure.amc.nl/en/publications/een-vrouw-met-een-voor-melanoom-verdachte-plek(fbdd369e-dcd2-45b3-b37a-60af20aa280f).html
Autor:
Ezziat Sakina, Leonidas Zografos, Gürkan Kaya, Rosanna Pescini Gobert, Alexandre Moulin, Donata Rimoldi, Ikram El Zaoui, Serge Leyvraz, Carlo Rivolta, Michael Nicolas, Nicola Bedoni, Maya Bucher, Ann Schalenbourg, Nicolo Riggi
Publikováno v:
Investigative ophthalmology & visual science, vol. 60, no. 7, pp. 2764-2772
Investigative Ophthalmology & Visual Science, Vol. 60, No 7 (2019) pp. 2764-2772
Investigative Ophthalmology & Visual Science, Vol. 60, No 7 (2019) pp. 2764-2772
To analyze the activity of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinases/mechanistic target of rapamycin (PI3K/mTOR) pathways in benign and malignant conjunctival melanocytic proliferations and explore whether specific inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f649a98d8f3cab0b5aed4aeee3cd1db2
https://doi.org/10.1167/iovs.18-26508
https://doi.org/10.1167/iovs.18-26508
Autor:
M M L Wong, Kwok-Yung Yuen, Ivan Hung, K S Chan, Richard Y.T. Kao, V C C Cheng, K H Chan, Yi Guan, Joseph S. M. Peiris, C L P Wong, Chung-Ming Chu, Leo L.M. Poon
Publikováno v:
Thorax
Background: The clinical response of patients with severe acute respiratory syndrome (SARS) to a combination of lopinavir/ritonavir and ribavirin was examined after establishing the in vitro antiviral susceptibility of the SARS associated coronavirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51de7430ebed23b3b6bedc9666d2541
Autor:
Alexandra Calmy, Andrew Carr, Handan Wand, David A. Cooper, Cécile Delhumeau, Bernard Hirschel, Richard Norris, M. Rafferty, Mark Bloch, Robert Finlayson
Publikováno v:
HIV Medicine, Vol. 11, No 8 (2010) pp. 493-501
Background Lipoatrophy can complicate thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI)-based antiretroviral therapy (ART). Lipoatrophy may be less likely with ART including ritonavir-boosted lopinavir (LPV/r). Small, placebo-cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993bab2688d5d8907259bfa54641b782
https://archive-ouverte.unige.ch/unige:20818
https://archive-ouverte.unige.ch/unige:20818
Autor:
Alexandra Calmy, Bernard Hirschel
Publikováno v:
New England Journal of Medicine, Vol. 358, No 20 (2008) pp. 2170-2172
Drugs that are used to treat patients with human immunodeficiency virus (HIV) infection are classified according to their target. The first ones to be developed were nucleoside reverse-transcriptase inhibitors (NRTIs), which lead to premature termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b5e34b8fb3d83e0820d8ed1ba15e9d
https://archive-ouverte.unige.ch/unige:2093
https://archive-ouverte.unige.ch/unige:2093