Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Pyrimidines/*adverse effects"'
Autor:
Gatzoulis, Michael A, Landzberg, Michael, Beghetti, Maurice, Berger, Rolf M, Efficace, Michela, Gesang, Sophie, He, Jian'guo, Papadakis, Kelly, Pulido, Tomás, Galiè, Nazzareno, MAESTRO Study Investigators
Publikováno v:
Circulation, 139(1), 51-63. LIPPINCOTT WILLIAMS & WILKINS
Circulation, Vol. 139, No 1 (2019) pp. 51-63
Circulation, Vol. 139, No 1 (2019) pp. 51-63
Background: Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed441d34aa3a8f7a94367cf4a62011fb
https://doi.org/10.1161/circulationaha.118.033575
https://doi.org/10.1161/circulationaha.118.033575
Autor:
Patricia N. Sidharta, Pierre Gueneau de Mussy, Marc Iglarz, Nicolas Guérard, Michel Burnier, Jasper Dingemanse, Grégoire Wuerzner, Marc Maillard, Bruno Flamion
Publikováno v:
Clinical pharmacology and therapeutics, vol. 109, no. 3, pp. 746-753
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
Aprocitentan is a novel, oral, dual endothelin receptor antagonist (ERA) in development in difficult-to-control hypertension. As fluid retention and edema are concerns with ERAs, we investigated whether aprocitentan causes weight gain in healthy subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a2c9329d030e44abc38075c4315ced
https://serval.unil.ch/notice/serval:BIB_1BE20415C0D5
https://serval.unil.ch/notice/serval:BIB_1BE20415C0D5
Autor:
Gatzoulis, M.A., Landzberg, M., Beghetti, M., Berger, R.M., Efficace, M., Gesang, S., He, J., Papadakis, K., Pulido, T., Galiè, N.
Publikováno v:
Circulation, vol. 139, no. 1, pp. 51-63
Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macitentan in Eis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::bfe35a2b36e413c7337ccb8cf1df5ac1
https://serval.unil.ch/notice/serval:BIB_2B3253EE0026
https://serval.unil.ch/notice/serval:BIB_2B3253EE0026
Autor:
Christine, Rossier, Vincent, Dunet, Frederic, Tissot, Berengère, Aubry-Rozier, Oscar, Marchetti, Olivier, Marchetti, Ariane, Boubaker
Publikováno v:
European journal of nuclear medicine and molecular imaging, vol. 39, no. 2, pp. 375-376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923e268f860cbd6faa0600e65d29ef7a
http://doc.rero.ch/record/319950/files/259_2011_Article_1922.pdf
http://doc.rero.ch/record/319950/files/259_2011_Article_1922.pdf
Autor:
Herbrink, Maikel, Groenland, Stefanie L, Huitema, Alwin D R, Schellens, Jan H M, Beijnen, Jos H, Steeghs, Neeltje, Nuijen, Bastiaan, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
International Journal of Pharmaceutics, 544(1), 181. Elsevier bedrijfsinformatie b.v.
International Journal of Pharmaceutics, 544(1), 181. Elsevier
International Journal of Pharmaceutics, 544(1), 181. Elsevier
The anti-cancer drug pazopanib hydrochloride (PZH) has a very low aqueous solubility and a variable oral bioavailability. A new pharmaceutical formulation with an improved solubility may enhance the bioavailability and reduce the variability. A broad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a696ebef5a8dde80adcd5575dd02bbf
https://dspace.library.uu.nl/handle/1874/364699
https://dspace.library.uu.nl/handle/1874/364699
Autor:
Lars Bastholt, Kirsten Madsen, Niels Viggo Jensen, Anne Robdrup Tinning, Boye L. Jensen, Camilla Bengtsen
Publikováno v:
Tinning, A R, Bengtsen, C, Jensen, N V, Bastholt, L, Jensen, B L & Madsen, K 2018, ' Pazopanib-Induced Hypertension in Patients With Renal Cell Carcinoma Is Associated With Low Urine Excretion of NO Metabolites ', Hypertension, vol. 71, no. 3, pp. 473-480 . https://doi.org/10.1161/HYPERTENSIONAHA.117.10225
Drugs targeting VEGF (vascular endothelial growth factor) are often associated with rapid development of hypertension by a yet not fully understood mechanism. VEGF is expressed in renal epithelial cells and stimulates NO production. In the renal medu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62d9d06a978e43f8452000b56dde383
https://pubmed.ncbi.nlm.nih.gov/29311252
https://pubmed.ncbi.nlm.nih.gov/29311252
Publikováno v:
Arquivos Brasileiros de Cardiologia v.103 n.5 2014
Arquivos Brasileiros de Cardiologia
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
Arquivos Brasileiros de Cardiologia, Vol 103, Iss 5, Pp 403-409 (2014)
Arquivos Brasileiros de Cardiologia
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
Arquivos Brasileiros de Cardiologia, Vol 103, Iss 5, Pp 403-409 (2014)
WOS: 000346165900010
PubMed ID: 25229355
Background: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged card
PubMed ID: 25229355
Background: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ea4d0c7c231cbaca95bb719ea8e289
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2014002300007
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2014002300007
Autor:
Saskia Bolay, Thierry Calandra, Oscar Marchetti, Andres Pascual, Thierry Buclin, Jacques Bille
Publikováno v:
Clinical Infectious Diseases, vol. 46, no. 2, pp. 201-211
BACKGROUND: Voriconazole is the therapy of choice for aspergillosis and a new treatment option for candidiasis. Liver disease, age, genetic polymorphism of the cytochrome CYP2C19, and comedications influence voriconazole metabolism. Large variations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c92cc71cb312fde4df31899e52221e0
https://doi.org/10.1086/524669
https://doi.org/10.1086/524669
Publikováno v:
Arquivos Brasileiros de Cardiologia, Volume: 103, Issue: 5, Pages: 403-409, Published: 12 SEP 2014
Background: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged cardiac repolarization and proarrhythmic electrophysiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______608::05d5a823be61182d70cbcac247e692b8
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2014002300007&lng=en&tlng=en
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2014002300007&lng=en&tlng=en
Venous thromboembolism (VTE) is serious medical condition, which might be caused by psychotropic medications. Previously, antipsychotic-induced VTE due to olanzapine, risperidone, clozapine, and amisulpiride was reported. In this report, we present 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4f1d0a68b5683f81cd9f86652c3e92
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/14485
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/14485