Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Pyrimidine-nucleoside phosphorylase"'
Akademický článek
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Akademický článek
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Publikováno v:
Biochemistry. 60:1573-1577
Enzyme-catalyzed reactions sometimes display curvature in their Eyring plots in the absence of denaturation, indicative of a change in activation heat capacity. However, the effects of pH and (de)protonation on this phenomenon have remained unexplore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ea87e4c4669432d0aeaa2aadcd93d5
https://doi.org/10.1021/acs.biochem.1c00156
https://doi.org/10.1021/acs.biochem.1c00156
Publikováno v:
Catalysis Science & Technology. 11:4439-4446
2-Halogenated-2′-deoxyadenosines are important antiviral and anticancer drugs. However, natural enzymes display low activities in the biosynthesis of 2-halogenated-2′-deoxyadenosines, and the results are unsatisfactory because of the steric imped
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1361aee981317193b07f625dd9763b54
https://doi.org/10.1039/d0cy02424d
https://doi.org/10.1039/d0cy02424d
Publikováno v:
Chembiochem
The poor solubility of many nucleosides and nucleobases in aqueous solution demands harsh reaction conditions (base, heat, cosolvent) in nucleoside phosphorylase‐catalyzed processes to facilitate substrate loading beyond the low millimolar range. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7567bff56ddc9103f785bc143c4e5a
http://europepmc.org/articles/PMC8247850
http://europepmc.org/articles/PMC8247850
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Enzyme-catalyzed reactions sometimes display curvature in their Eyring plots in the absence of denaturation, indicative of a change in activation heat capacity. However, pH and (de)protonation effects on this phenomenon have remained unexplored. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a959588042781472be0c3c454bdb839
https://doi.org/10.26434/chemrxiv.14135840
https://doi.org/10.26434/chemrxiv.14135840
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 74:193-197
Pyrimidine-nucleoside phosphorylase catalyzes the phosphorolytic cleavage of thymidine and uridine with equal activity. Investigation of this protein is essential for anticancer drug design. Here, the structure of this protein fromBacillus subtilisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2da44350a7824a5a12a451105b2813d
https://doi.org/10.1107/s2053230x18002935
https://doi.org/10.1107/s2053230x18002935
Autor:
Giessmann, Robert T., Krausch, Niels, Kaspar, Felix, Cruz-Bournazou, Mariano Nicolas, Wagner, Anke, Neubauer, Peter, Gimpel, Matthias
Publikováno v:
Processes, Vol 7, Iss 6, p 380 (2019)
Processes, 7 (6)
Processes
Volume 7
Issue 6
Processes, 7 (6)
Processes
Volume 7
Issue 6
Pyrimidine-nucleoside phosphorylases (Py-NPases) have a significant potential to contribute to the economic and ecological production of modified nucleosides. These can be produced via pentose-1-phosphates, an interesting but mostly labile and expens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cdb8f06045fdec0c8296c35ce781fb
https://www.mdpi.com/2227-9717/7/6/380
https://www.mdpi.com/2227-9717/7/6/380
Autor:
Al'bert M. Mikhailov, Alexander Mironov, V.V. Balaev, I.I. Prokofev, Christian Betzel, Azat Gabdulkhakov, T. A. Seregina, A. A. Lashkov
Publikováno v:
Crystallography Reports. 61:830-841
Pyrimidine nucleoside phosphorylases, which are widely used in the biotechnological production of nucleosides, have different substrate specificity for pyrimidine nucleosides. An interesting feature of these enzymes is that the three-dimensional stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90171574403caf745b182ff4c77122d8
https://doi.org/10.1134/s1063774516050023
https://doi.org/10.1134/s1063774516050023