Response and Resistance to Trametinib in MAP2K1-Mutant Triple-Negative Melanoma

Autor: Fanny Seraphine Krebs, Bianca Moura, Edoardo Missiaglia, Veronica Aedo-Lopez, Olivier Michielin, Petros Tsantoulis, Bettina Bisig, Mounir Trimech, Vincent Zoete, Krisztian Homicsko

Publikováno v: International journal of molecular sciences, vol. 24, no. 5, pp. 4520

The development of targeted therapies for non-BRAF p.Val600-mutant melanomas remains a challenge. Triple wildtype (TWT) melanomas that lack mutations in BRAF, NRAS, or NF1 form 10% of human melanomas and are heterogeneous in their genomic drivers. MA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c2d7b7bfc9703cd98b057de8fcea53
https://serval.unil.ch/notice/serval:BIB_E3A48A3138B7

Outcomes of patients with advanced idiopathic pulmonary fibrosis treated with nintedanib or pirfenidone in a real-world multicentre cohort

Autor: Michael T. Durheim, Tone Sjåheim, Charlotte Hyldgaard, Elisabeth Bendstrup, Marjukka Myllärniemi, Dimitrios Kalafatis, Lisa Carlson, Eva Sutinen, C. Magnus Sköld

Publikováno v: Durheim, M T, Bendstrup, E, Carlson, L, Sutinen, E M, Hyldgaard, C, Kalafatis, D, Myllärniemi, M, Sköld, C M & Sjåheim, T 2021, ' Outcomes of patients with advanced idiopathic pulmonary fibrosis treated with nintedanib or pirfenidone in a real-world multicentre cohort ', Respirology, vol. 26, no. 10, pp. 982-988 . https://doi.org/10.1111/resp.14116

Background and objective: Antifibrotic therapy with nintedanib or pirfenidone slows disease progression and reduces mortality in patients with idiopathic pulmonary fibrosis (IPF). However, patients with advanced IPF, as defined by forced vital capaci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe986efb391d30ca7852dd64120de55
https://pure.au.dk/portal/da/publications/outcomes-of-patients-with-advanced-idiopathic-pulmonary-fibrosis-treated-with-nintedanib-or-pirfenidone-in-a-realworld-multicentre-cohort(06f0874b-070a-4c34-99cf-bfd164a23607).html

Efficacy and safety of dolutegravir plus emtricitabine versus standard ART for the maintenance of HIV-1 suppression: 48-week results of the factorial, randomized, non-inferiority SIMPL'HIV trial

Autor: Sculier, Delphine, Wandeler, Gilles, Yerly Ferrillo, Sabine, Marinosci, Annalisa, Stoeckle, Marcel, Bernasconi, Enos, Braun, Dominique L., Vernazza, Pietro, Cavassini, Matthias, Buzzi, Marta, Metzner, Karin J., Decosterd, Laurent A., Günthard, Huldrych F., Schmid, Patrick, Limacher, Andreas, Egger, Matthias, Calmy, Alexandra, Swiss HIV Cohort Study (SHCS)

Publikováno v: PLoS Medicine
PLOS Medicine, Vol. 17, No 11 (2020) P. e1003421
PLoS Medicine, Vol 17, Iss 11, p e1003421 (2020)
PLoS medicine, vol. 17, no. 11, pp. e1003421
Sculier, Delphine; Wandeler, Gilles; Yerly, Sabine; Marinosci, Annalisa; Stoeckle, Marcel; Bernasconi, Enos; Braun, Dominique L; Vernazza, Pietro; Cavassini, Matthias; Buzzi, Marta; Metzner, Karin J; Decosterd, Laurent A; Günthard, Huldrych F; Schmid, Patrick; Limacher, Andreas; Egger, Matthias; Calmy, Alexandra (2020). Efficacy and safety of dolutegravir plus emtricitabine versus standard ART for the maintenance of HIV-1 suppression: 48-week results of the factorial, randomized, non-inferiority SIMPL'HIV trial. PLoS medicine, 17(11), e1003421. Public Library of Science 10.1371/journal.pmed.1003421

Background Dolutegravir (DTG)–based dual therapy is becoming a new paradigm for both the initiation and maintenance of HIV treatment. The SIMPL’HIV study investigated the outcomes of virologically suppressed patients on standard combination antir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdd4c65511c7d667a0d2980ff73e398
https://pubmed.ncbi.nlm.nih.gov/33170863

Een vrouw met een voor melanoom verdachte plek

Autor: Post, Nicoline F, Huis In 't Veld, Eva, Crijns, Marianne B

Publikováno v: Nederlands tijdschrift voor geneeskunde, 164. Bohn Stafleu van Loghum

We saw a 59-year-old patient who was treated with dabrafenib and trametinib because of metastatic melanoma. She had an asymptomatic, black-blue macula in the excision scar. Histopathology showed tumoral melanosis. This is an histological term for der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a2973bdb6873a55dde1d4cfd4eba99d3
https://pure.amc.nl/en/publications/een-vrouw-met-een-voor-melanoom-verdachte-plek(fbdd369e-dcd2-45b3-b37a-60af20aa280f).html

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