Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Pyridines/pharmacology"'
Autor:
Pancholi, Sunil, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Nikitorowicz-Buniak, Joanna, Ressa, Anna, Gao, Qiong, Leal, Mariana Ferreira, Bhamra, Amandeep, Thornhill, Allan, Morisset, Ludivine, Montaudon, Elodie, Sourd, Laura, Fitzpatrick, Martin, Altelaar, Maarten, Johnston, Stephen R, Marangoni, Elisabetta, Dowsett, Mitch, Martin, Lesley-Ann, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics
Publikováno v:
Oncogene, 39(25), 4781. Nature Publishing Group
Oncogene
Oncogene
Combination of CDK4/6 inhibitors and endocrine therapy improves clinical outcome in advanced oestrogen receptor (ER)-positive breast cancer, however relapse is inevitable. Here, we show in model systems that other than loss ofRB1few gene-copy number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83726164166fa3f899deca8969edd34c
https://doi.org/10.1038/s41388-020-1284-6
https://doi.org/10.1038/s41388-020-1284-6
Autor:
Chanyi Lu, Xiaoli Lin, Jumpei Yamashita, Ranhui Xi, Minliang Zhou, Yali V. Zhang, Hong Wang, Robert F. Margolskee, Bon-Kyoung Koo, Hans Clevers, Ichiro Matsumoto, Peihua Jiang
Publikováno v:
Stem Cell Reports, 17(2), 369-383. Cell Press
Taste bud cells are renewed throughout life in a process requiring innervation. Recently, we reported that R-spondin substitutes for neuronal input for taste cell regeneration. R-spondin amplifies WNT signaling by interacting with stem-cell-expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fbbb32fc7ce9e25325c3bf90b0952a
https://pubmed.ncbi.nlm.nih.gov/34995498
https://pubmed.ncbi.nlm.nih.gov/34995498
Autor:
Sabina S Cosulich, Abigail Shea, Maurizio Callari, A. Dariush, Elena Provenzano, Martin O'Reilly, Carlos Caldas, Dimitra Georgopoulou, Agnese Giovannetti, Oscar M. Rueda, Gregory J. Hannon, Suet-Feung Chin, Giulia Lerda, Elham Esmaeilishirazifard, Alistair Martin, Violeta Serra, Fatime Qosaj, Wendy Greenwood, Dario Bressan, Larissa S. Carnevalli, Alejandra Bruna, H. Raza Ali, Gordon B. Mills
Publikováno v:
Nature Communications
Nature communications, vol. 12, no. 1, pp. 1998
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature communications, vol. 12, no. 1, pp. 1998
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to identify cell phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0712127e8562959156b1ae7983d647f
Autor:
Aakash Patel, Hala Guedouari, Elzbieta Janda, Karine Reybier, Istvan Gacsalyi, Vishalgiri Goswami, Jean A. Boutin, Adeline Giganti, Mathias Antoine, Monivan Chhour, Marie-Claude Viaud-Massuard, Hervé Da Costa, Marc Bertrand, Pierre Ducrot, Jérôme Paysant, Patrick P. Michel, Gilles Ferry, Thierry Le Diguarher, Daniel A. Kane, Françoise Nepveu, Frédéric Bouillaud, Karen Brebner, Gérald Guillaumet, Etienne C. Hirsch, Philippe Dupuis, Johann Stojko
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
International audience; Quinone reductase 2 (QR2, E.C. 1.10.5.1) is an enzyme with a feature that has attracted attention for several decades: in standard conditions, instead of recognizing NAD(P)H as an electron donor, it recognizes putative metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c332ae7dd4579c5014783569d4574301
https://www.hal.inserm.fr/inserm-02334766
https://www.hal.inserm.fr/inserm-02334766
Autor:
Dangxiao Cheng, Zhuo Chen, Henry Thai, Trevor Morey, Laurie Ailles, Osvaldo Espin-Garcia, Joerg Schwock, Lucy Liu, Helen Mackay, Hala Girgis, Jennifer Teichman, Geoffrey Liu, Andrew Fleet, Gail Darling, Wei Xu, Madison McGregor, Yuyao Song, Robert G. Bristow, Yonathan Brhane, Lorin Dodbiba
Publikováno v:
PLoS ONE
Teichman, J, Dodbiba, L, Thai, H, Fleet, A, Morey, T, Liu, L, McGregor, M, Cheng, D, Chen, Z, Darling, G, Brhane, Y, Song, Y, Espin-Garcia, O, Xu, W, Girgis, H, Schwock, J, MacKay, H, Bristow, R, Ailles, L & Liu, G 2018, ' Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma ', PLoS ONE, vol. 13, no. 5, pp. e0194809 . https://doi.org/10.1371/journal.pone.0194809
PLoS ONE, Vol 13, Iss 5, p e0194809 (2018)
Teichman, J, Dodbiba, L, Thai, H, Fleet, A, Morey, T, Liu, L, McGregor, M, Cheng, D, Chen, Z, Darling, G, Brhane, Y, Song, Y, Espin-Garcia, O, Xu, W, Girgis, H, Schwock, J, MacKay, H, Bristow, R, Ailles, L & Liu, G 2018, ' Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma ', PLoS ONE, vol. 13, no. 5, pp. e0194809 . https://doi.org/10.1371/journal.pone.0194809
PLoS ONE, Vol 13, Iss 5, p e0194809 (2018)
BACKGROUND: The Hedgehog (Hh) signaling pathway is active in esophageal adenocarcinoma (EAC). We used a patient-derived murine xenograft (PDX) model of EAC to evaluate tumour response to conventional treatment with radiation/chemoradiation with or wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba143b2fd9699ec9f7d0ce18b82f7ba
http://europepmc.org/articles/PMC5929523
http://europepmc.org/articles/PMC5929523
Autor:
Laurence Cocquerel, Yves Rouillé, Didier Hober, Rayan Farhat, Sandrine Belouzard, Juliette Ferlin, Antoine Bertin, Jean Dubuisson
Publikováno v:
Journal of General Virology
Journal of General Virology, Microbiology Society, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
Journal of General Virology, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
Journal of General Virology, Microbiology Society, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
Journal of General Virology, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
International audience; GBF1 has emerged as a host factor required for the replication of positive-sense single-stranded RNA viruses of different families, but its mechanism of action is still unknown. GBF1 is a guanine nucleotide exchange factor for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f61a159d161901a3885c57f1e24dc7b
https://hal.archives-ouvertes.fr/hal-02113930
https://hal.archives-ouvertes.fr/hal-02113930
Autor:
Giuseppe Tonini, Bruno Vincenzi, Antonio Russo, Marco Fioramonti, Paolo Manca, Daniele Santini, Filippo Spiezia, Vincenzo Denaro, Giulia Ribelli, Francesco Pantano, Michele Iuliani, Nicola Papapietro
Publikováno v:
Oncotarget
Oncotarget, 8 (12
Oncotarget, 8 (12
Cabozantinib, a c-MET and vascular endothelial growth factor receptor 2 inhibitor, demonstrated to prolong progression free survival and improve skeletal disease-related endpoints in castration-resistant prostate cancer and in metastatic renal carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87a95b9af610a4976928c4ef040bd09
http://hdl.handle.net/10447/249539
http://hdl.handle.net/10447/249539
Autor:
Johannes Roth, Yvonne Börgeling, Carolin Nordhoff, Mirco Schmolke, Dorothee Viemann, Stephan Ludwig
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry, Vol. 289, No 1 (2014) pp. 13-27
Journal of Biological Chemistry, Vol. 289, No 1 (2014) pp. 13-27
Background: Early cytokine dysregulation upon infection with highly pathogenic avian influenza viruses (HPAIV) is a major determinant of viral pathogenicity. Results: p38 MAPK controls HPAIV-induced gene expression by regulating interferon synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4959712dd5724faba43ebc04f21f8bab
http://europepmc.org/articles/PMC3879537
http://europepmc.org/articles/PMC3879537
Publikováno v:
Molecular and Cellular Proteomics, Vol. 11, No 8 (2012) pp. 244-54
Insulin secretory granules are β-cell vesicles dedicated to insulin processing, storage, and release. The secretion of insulin secretory granule content in response to an acute increase of glucose concentration is a highly regulated process allowing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c9bea3dfeb08089c7bfdee24513e52
https://doi.org/10.1074/mcp.m112.018051
https://doi.org/10.1074/mcp.m112.018051
Autor:
Maté Biro, Annelie Oswald, Guillaume Salbreux, Jakub Sedzinski, Ewa K. Paluch, Jean-Yves Tinevez
Publikováno v:
Nature
Nature, Nature Publishing Group, 2011, 476 (7361), pp.462-466. ⟨10.1038/nature10286⟩
Nature, Nature Publishing Group, 2011, 476 (7361), pp.462-466. ⟨10.1038/nature10286⟩
Studies of the mechanism of cytokinesis, the process by which a mother cell undergoes cleavage to form two separated daughter cells, often focus on the action of the contractile actomyosin ring at the cell equator. Ewa Paluch and colleagues instead i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c082b86ec2f93524d871f810b1eecb36
https://doi.org/10.1038/nature10286
https://doi.org/10.1038/nature10286