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Subtype-specific actions of beta-amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (alpha7, alpha4beta2, alpha3beta4) expressed in Xenopus laevis oocytes

Autor: Pym, L, Kemp, M, Raymond-Delpech, V, Buckingham, S, Boyd, CA, Sattelle, D

Two-electrode voltage-clamp electrophysiology has been used to study the actions of two amyloid peptides (Abeta(1-42), Abeta(1-40)) on alpha7, alpha4beta2 and alpha3beta4 recombinant human neuronal nicotinic acetylcholine receptors (nicotinic AChRs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::be997c2c57eb04779eb8a05de54a4490
https://doi.org/10.1038/sj.bjp.0706403

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The Abeta1-42M35C mutated amyloid peptide Abeta1-42 and the 25-35 fragment fail to mimic the subtype-specificity of actions on recombinant human nicotinic acetylcholine receptors (alpha7, alpha4beta2, alpha3beta4)

Autor: Pym, L, Buckingham, S, Tsetlin, V, Boyd, C, Sattelle, D

Publikováno v: Neuroscience letters. 427(1)

Alzheimer's disease (AD) is a neurodegenerative condition involving accumulation of the beta-amyloid peptide, Abeta1-42. Previously we have shown that amyloid peptides (Abeta1-42, Abeta1-40) have different actions on the three major brain nicotinic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9d88df974cb4f0d6586fe8d5a429a137
http://ora.ox.ac.uk/objects/uuid:49c2f53e-78f1-4411-8b5a-6880d14e6680

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Subtype-specific actions of β-amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (α7, α4β2, α3β4) expressed in Xenopus laevis oocytes

Autor: Pym, L, Kemp, M, Raymond-Delpech, V, Buckingham, S, Boyd, C, Sattelle, D

Publikováno v: British Journal of Pharmacology. 146(7)

1 Two-electrode voltage-clamp electrophysiology has been used to study the actions of two amyloid peptides (Aβ 1-42, Aβ 1-40) on α7, α4β2 and α3β4 recombinant human neuronal nicotinic acetylcholine receptors (nicotinic AChRs), heterologously e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e2177df32e429639ebd56f1671d86569
http://ora.ox.ac.uk/objects/uuid:a06f0358-e24f-46df-a5ba-78aa8432e2ce

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A7DB: a relational database for mutational, physiological and pharmacological data related to the α7 nicotinic acetylcholine receptor

Autor: Buckingham, S, Pym, L, Jones, A, Brown, L, Sansom, MS, Sattelle, D, Biggin, P

Publikováno v: BMC Neuroscience, Vol 6, Iss 1, p 2 (2005)

Background: Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::138ab21fbe80a5f734effd0b64889fe7
http://www.biomedcentral.com/1471-2202/6/2

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Who should give lifestyle advice in general practice and what factors influence attendance at health promotion clinics? Survey of patients' views

Autor: Eggleston, J, Gallagher, J, Gallagher, M, Hares, T, Murray, E, Naroz, N, Owen, T, Price, P, Pym, L, Reed, L

BACKGROUND: Health promotion activity in general practice has increased greatly since 1990. A large proportion of this work is undertaken by practice nurses. Little is known about patients' views about the providers of health promotion or their views

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3103d0ff704e9dc5d9b6b5e52da123d
https://europepmc.org/articles/PMC1239471/

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