Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection

Autor: Peiró, T, Patel, DF, Akthar, S, Gregory, LG, Pyle, CJ, Harker, JA, Birrell, MA, LLoyd, CM, Snelgrove, RJ

Background Alveolar macrophages are sentinels of the airways that must exhibit immune restraint to innocuous antigens but elicit a robust inflammatory response to pathogenic threats. How distinction between these dichotomous functions is controlled i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::38fa67834cb846c8ffdde0eaa282e551
http://hdl.handle.net/10044/1/51722

The Many Hosts of Mycobacteria 9 (MHM9): A conference report.

Autor: Klever AM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Alexander KA; Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, VA, USA; CARACAL/Chobe Research Institute Kasane, Botswana., Almeida D; Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD, USA., Anderson MZ; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA; Department of Microbiology, The Ohio State University, Columbus, OH, USA., Ball RL; Eckerd College, St. Petersburg, FL, USA., Beamer G; Host Pathogen Interactions and Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Boggiatto P; Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA., Buikstra JE; Center for Bioarchaeological Research, Arizona State University, Tempe, AZ, USA., Chandler B; Division of Public Health, Alaska Department of Health, AK, USA., Claeys TA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Concha AE; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Converse PJ; Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD, USA., Derbyshire KM; Division of Genetics, The Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Biomedical Sciences, University at Albany, Albany, NY, USA., Dobos KM; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA., Dupnik KM; Center for Global Health, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Endsley JJ; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Endsley MA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Fennelly K; Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, USA., Franco-Paredes C; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA; Hospital Infantil de México Federico Gómez, México, USA., Hagge DA; The Leprosy Mission International, Kathmandu, Nepal., Hall-Stoodley L; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Hayes D Jr; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Hirschfeld K; Department of Anthropology, University of Oklahoma, Norman, OK, USA., Hofman CA; Department of Anthropology, University of Oklahoma, Norman, OK, USA; Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK, USA., Honda JR; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Hull NM; Department of Civil, Environmental, and Geodetic Engineering, The Ohio State University, Columbus, OH, USA., Kramnik I; Pulmonary Center, The Department of Medicine, Boston University Chobanian & Aveedisian School of Medicine, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Lacourciere K; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Lahiri R; United States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA, USA., Lamont EA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Larsen MH; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Lemaire T; Norton Sound Health Corporation, Nome, AK, USA., Lesellier S; French Agency for Food, Environmental & Occupational Health & Safety (ANSES), Laboratory for Rabies and Wildlife,Nancy, France., Lee NR; Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ, USA., Lowry CA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Mahfooz NS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., McMichael TM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Merling MR; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Miller MA; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Nagajyothi JF; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Nelson E; Microbial Paleogenomics Unit, Dept of Genomes and Genetics, Institut Pasteur, Paris, France., Nuermberger EL; Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD, USA., Pena MT; United States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA, USA., Perea C; Animal & Plant Health Inspection Service, United States Department of Agriculture, Ames, IA, USA., Podell BK; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA., Pyle CJ; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, USA; Department of Immunology, Duke University School of Medicine, Durham, NC, USA., Quinn FD; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA., Rajaram MVS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Mejia OR; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Rothoff M; Division of Public Health, Alaska Department of Health, AK, USA., Sago SA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Salvador LCM; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, USA., Simonson AW; Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Spencer JS; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA., Sreevatsan S; Pathobiology & Diagnostic Investigation Department, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA., Subbian S; Public Health Research Institute (PHRI), New Jersey Medical School, Rutgers University, Newark, NJ, USA., Sunstrum J; Corewell East Health, Westland, MI, USA., Tobin DM; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, USA; Department of Immunology, Duke University School of Medicine, Durham, NC, USA., Vijayan KKV; Department of Microbiology and Immunology, Center for AIDS Research, and Children's Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wright CTO; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA., Robinson RT; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA. Electronic address: richard.robinson@osumc.edu.

Publikováno v: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2023 Sep; Vol. 142, pp. 102377. Date of Electronic Publication: 2023 Jul 23.

Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity.

Autor: Pyle CJ; National Heart and Lung Institute, Imperial College London, South Kensington, London, UK., Labeur-Iurman L; National Heart and Lung Institute, Imperial College London, South Kensington, London, UK., Groves HT; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Puttur F; National Heart and Lung Institute, Imperial College London, South Kensington, London, UK., Lloyd CM; National Heart and Lung Institute, Imperial College London, South Kensington, London, UK.; Asthma UK Centre in Allergic Mechanisms for Asthma, London, UK., Tregoning JS; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Harker JA; National Heart and Lung Institute, Imperial College London, South Kensington, London, UK.; Asthma UK Centre in Allergic Mechanisms for Asthma, London, UK.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2021 Dec 06; Vol. 218 (12). Date of Electronic Publication: 2021 Oct 19.

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.

Autor: Turnbull AR; Cystic Fibrosis and Chronic Lung Infection, National Heart & Lung Institute, Imperial College London, United Kingdom; Paediatric Respiratory Medicine, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom., Pyle CJ; Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom., Patel DF; Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom., Jackson PL; Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, United States of America; Birmingham V.A. Medical Centre, Birmingham, AL 35294, United States of America., Hilliard TN; Cystic Fibrosis and Chronic Lung Infection, National Heart & Lung Institute, Imperial College London, United Kingdom; Paediatric Respiratory Medicine, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom., Regamey N; Paediatric Respiratory Medicine, Children's Hospital, Lucerne, Switzerland., Tan HL; Paediatric Respiratory Medicine, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom., Brown S; Paediatric Respiratory Medicine, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom; Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom., Thursfield R; Alder Hey Children's NHS Foundation Trust, Liverpool L14 5AB, United Kingdom., Short C; Cystic Fibrosis and Chronic Lung Infection, National Heart & Lung Institute, Imperial College London, United Kingdom., Mc Fie M; Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom., Alton EWFW; Cystic Fibrosis and Chronic Lung Infection, National Heart & Lung Institute, Imperial College London, United Kingdom., Gaggar A; Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, United States of America; Birmingham V.A. Medical Centre, Birmingham, AL 35294, United States of America., Blalock JE; Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, United States of America., Lloyd CM; Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom., Bush A; Paediatric Respiratory Medicine, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom; Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom., Davies JC; Cystic Fibrosis and Chronic Lung Infection, National Heart & Lung Institute, Imperial College London, United Kingdom; Paediatric Respiratory Medicine, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom., Snelgrove RJ; Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom. Electronic address: robert.snelgrove@imperial.ac.uk.

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2020 Jan; Vol. 19 (1), pp. 40-48. Date of Electronic Publication: 2019 Jun 05.

Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.

Autor: Uwadiae FI; Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, UK.; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Pyle CJ; Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, UK., Walker SA; Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, UK.; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Lloyd CM; Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, UK.; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Harker JA; Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, UK.; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.

Publikováno v: Allergy [Allergy] 2019 Apr; Vol. 74 (4), pp. 650-662. Date of Electronic Publication: 2018 Nov 12.