Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A4 hydrolase

Autor: Penning, Thomas D.¹ thomas.d.penning@pharmacia.com, Chandrakumar, Nizal S.¹, Desai, Bipin N.¹, Djuric, Stevan W.¹, Gasiecki, Alan F.¹, Liang, Chi-Dean¹, Miyashiro, Julie M.¹, Russell, Mark A.¹, Askonas, Leslie J.², Gierse, James K.², Harding, Elizabeth I.², Highkin, Maureen K.², Kachur, James F.², Kim, Suzanne H.², Villani-Price, Doreen², Pyla, E. Yvonne², Ghoreishi-Haack, Nayereh S.², Smith, Walter G.²

Publikováno v: Bioorganic & Medicinal Chemistry Letters. Dec2002, Vol. 12 Issue 23, p3383. 4p.

Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.

Autor: Penning TD; Department of Medicinal Chemistry, Pharmacia Corporation, 4901 Searle Parkway, Skokie, IL 60077, USA. thomas.d.penning@pharmacia.com, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Malecha JW, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Mar 24; Vol. 13 (6), pp. 1137-9.

Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.

Autor: Penning TD; Department of Medicinal Chemistry, Pharmacia Corporation, 4901 Searle Parkway, Skokie, IL 60077, USA. thomas.d.penning@pharmacia.com, Russell MA, Chen BB, Chen HY, Liang CD, Mahoney MW, Malecha JW, Miyashiro JM, Yu SS, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2002 Aug 01; Vol. 45 (16), pp. 3482-90.