Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Puya Aravand"'
Autor:
Jean Bennett, Puya Aravand, Pavitra S. Ramachandran, Ivan Schpylchak, Nicholas T. Phelps, Sergei Nikonov
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
There has been marked progress in recent years in developing gene delivery approaches for the treatment of inherited blinding diseases. Many of the proof-of-concept studies have utilized rodent models of retinal degeneration. In those models, tests o
Externí odkaz:
https://doaj.org/article/c93289b706b046deb39c9481efd18f89
Autor:
Jipeng Yue, Reas S. Khan, Thu T. Duong, Kimberly E. Dine, Qi N. Cui, Nuala O’Neill, Puya Aravand, Tehui Liu, Brahim Chaqour, Kenneth S. Shindler, Ahmara G. Ross
Publikováno v:
Neurotherapeutics.
Autor:
Sergei Nikonov, Puya Aravand, Arkady Lyubarsky, Roman Nikonov, Angela J. Luo, Zhangyong Wei, Albert M. Maguire, Nicholas T. Phelps, Ivan Shpylchak, Keirnan Willett, Tomas S. Aleman, Rachel M. Huckfeldt, Pavitra S. Ramachandran, Jean Bennett
Publikováno v:
Translational vision sciencetechnology. 11(5)
Optogenetic gene therapy to render remaining retinal cells light-sensitive in end-stage retinal degeneration is a promising strategy for treatment of individuals blind because of a variety of different inherited retinal degenerations. The clinical tr
Autor:
Ahmara G. Ross, Kimberly Dine, Devin S. McDougald, Thu T. Duong, Kenneth S. Shindler, Puya Aravand, Venkata R M Chavali, Jean Bennett, Reas S. Khan
Publikováno v:
Gene Therapy
SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests this is through oxidative stress to either n
Autor:
Ivan Shpylchak, Vidyullatha Vasireddy, Katherine E. Uyhazi, Denise J. Pearson, Zhangyong Wei, Jean Bennett, Lanfranco Leo, Leona W. Serrano, Puya Aravand, Tomas S. Aleman, Brent A. Bell, Jennifer Pham
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To determine the therapeutic window for gene augmentation for Leber congenital amaurosis (LCA) associated with mutations in LCA5. Methods Five patients (ages 6-31) with LCA and biallelic LCA5 mutations underwent an ophthalmic examination incl
Autor:
Patsy M. Nishina, Jeannette L. Bennicelli, Jieyan Pan, Ji Yun Song, Frans P.M. Cremers, Tomas S. Aleman, Ilan McNamara, Shangzhen Zhou, Gui-Shuang Ying, Junwei Sun, Lanfranco Leo, Puya Aravand, Pamela S. Herrera, Arkady Lyubarsky, Ivan Shpylchak, Zhangyong Wei, Albert M. Maguire, Sergei Nikonov, Jennifer Pham, Robert K. Koenekoop, Wei Pan, Daniel J Bennett, Ronald Roepman, Jimmy de Melo, Jason A. Mills, Nicoletta Commins, Anneke I. den Hollander, Jean Bennett
Publikováno v:
Molecular Therapy, 26, 1581-1593
Molecular Therapy, 26, 6, pp. 1581-1593
Molecular Therapy, 26, 6, pp. 1581-1593
Item does not contain fulltext Most genetically distinct inherited retinal degenerations are primary photoreceptor degenerations. We selected a severe early onset form of Leber congenital amaurosis (LCA), caused by mutations in the gene LCA5, in orde
Autor:
Mani Mahmoudian, Elena S. Nikonova, Aimee E. Willett, Puya Aravand, Manzar Ashtari, Jean Bennett, Gui-Shuang Ying, Wei Pan, Kathleen A. Marshall, Albert M. Maguire, Gloria J. Young
Publikováno v:
Ophthalmology. 124:873-883
Purpose Gene therapy (GT) has offered immense hope to individuals who are visually impaired because of RPE65 mutations. Although GT has shown great success in clinical trials enrolling these individuals, evidence for stability and durability of this
Autor:
Reas S. Khan, Kenneth S. Shindler, Kimberly Dine, Evan B. Selzer, Ahmara G. Ross, Puya Aravand
Publikováno v:
Translational Vision Science & Technology
Purpose Traumatic optic neuropathy (TON) is often caused by blunt head trauma and has no currently effective treatment. Common animal models of TON induced by surgical crush injury are plagued by variability and do not mimic typical mechanisms of TON
Autor:
Alberto Auricchio, Katherine A. High, Julie DiStefano-Pappas, Kathleen A. Marshall, Dominique Cross, J. Fraser Wright, Albert M. Maguire, Puya Aravand, Okan U. Elci, Sarah McCague, Federico Mingozzi, Laura Cyckowski, Bart P. Leroy, Daniel C. Chung, Jennifer Wellman, Jason Ruggiero, Francesca Simonelli, Eric A. Pierce, Junwei Sun, Manzar Ashtari, Jeannette L. Bennicelli, Jean Bennett
Publikováno v:
LANCET
LANCET, 2016, 388 (10045), pp.661-72. ⟨10.1016/S0140-6736(16)30371-3⟩
The Lancet
The Lancet, 2016, 388 (10045), pp.661-72. ⟨10.1016/S0140-6736(16)30371-3⟩
LANCET, 2016, 388 (10045), pp.661-72. ⟨10.1016/S0140-6736(16)30371-3⟩
The Lancet
The Lancet, 2016, 388 (10045), pp.661-72. ⟨10.1016/S0140-6736(16)30371-3⟩
International audience; BACKGROUND: Safety and efficacy have been shown in a phase 1 dose-escalation study involving a unilateral subretinal injection of a recombinant adeno-associated virus (AAV) vector containing the RPE65 gene (AAV2-hRPE65v2) in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9adfa71eeaec8bb5fe1e821d109f2c2
http://hdl.handle.net/11591/358419
http://hdl.handle.net/11591/358419
Autor:
Jean Bennett, James C. Gee, Arastoo Vossough, Hui Zhang, Philip A. Cook, Kenneth S. Shindler, Chris I. Baker, Laura Cyckowski, Puya Aravand, Manzar Ashtari, Albert M. Maguire, Kathleen A. Marshall
Much of our knowledge of the mechanisms underlying plasticity in the visual cortex in response to visual impairment, vision restoration, and environmental interactions comes from animal studies. We evaluated human brain plasticity in a group of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf36d4e890d43497c97c4cb9ced9424
https://europepmc.org/articles/PMC4617524/
https://europepmc.org/articles/PMC4617524/