Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Pushpa Pandiyan"'
Autor:
Nisha J. D’Silva, Pushpa Pandiyan
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Inflammation is a process that is associated with the activation of distal immunosuppressive pathways that have evolved to restore homeostasis and prevent excessive tissue destruction. However, long-term immunosuppression resulting from systemic and
Externí odkaz:
https://doaj.org/article/46db32ac328b4ec78e21ac6abb333379
Autor:
Shanmuga Sundaram Mahalingam, Sangeetha Jayaraman, Adhvika Arunkumar, Holly M. Dudley, Donald D. Anthony, Carey L. Shive, Jeffrey M. Jacobson, Pushpa Pandiyan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19) that presents with varied clinical manifestations ranging from asymptomatic or mild infections and pneumonia to severe cases associated with cytok
Externí odkaz:
https://doaj.org/article/a75f7b50e5ed437bbec05ec3bbadc701
Autor:
Carey Shive, Pushpa Pandiyan
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
An optimal immune response requires the appropriate interaction between the innate and the adaptive arms of the immune system as well as a proper balance of activation and regulation. After decades of life, the aging immune system is continuously exp
Externí odkaz:
https://doaj.org/article/4603f80006d4461fbc99a3b75ad25fac
Autor:
Ann W.N. Auma, Carey L. Shive, Alyssa Lange, Sofi Damjanovska, Corinne Kowal, Elizabeth Zebrowski, Pushpa Pandiyan, Brigid Wilson, Robert C. Kalayjian, David H. Canaday, Donald D. Anthony
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundThe mechanisms underlying naïve CD4+ lymphopenia during chronic Hepatitis C Virus (HCV) infection are unclear. Whether direct-acting antiviral (DAA) therapy restores peripheral naïve CD4+ T cell numbers and function is unknown.MethodsWe e
Externí odkaz:
https://doaj.org/article/639e6fbfad364c11bc4487545f3d378e
Autor:
Natarajan Bhaskaran, Sangeetha Jayaraman, Cheriese Quigley, Prerna Mamileti, Mahmoud Ghannoum, Aaron Weinberg, Jason Thuener, Quintin Pan, Pushpa Pandiyan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
An increased accumulation of immune-dysfunction-associated CD4+Foxp3+ regulatory T cells (Tregs) is observed in aging oral mucosa during infection. Here we studied the function of Tregs during oral cancer development in aging mucosa. First, we found
Externí odkaz:
https://doaj.org/article/eda5ba238167456c96e6558351a54fb2
Autor:
Natarajan Bhaskaran, Fady Faddoul, Andre Paes da Silva, Sangeetha Jayaraman, Elizabeth Schneider, Prerna Mamileti, Aaron Weinberg, Pushpa Pandiyan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
CD4+Foxp3+Tregs maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3+ cells altered their function and resul
Externí odkaz:
https://doaj.org/article/ef208c0b9bd7407f9b402272d331ef92
Publikováno v:
Pathogens, Vol 11, Iss 2, p 212 (2022)
Candida albicans is a commensal fungus that asymptomatically colonizes the skin and mucosa of 60% of healthy individuals. Breaches in the cutaneous and mucosal barriers trigger candidiasis that ranges from asymptomatic candidemia and mucosal infectio
Externí odkaz:
https://doaj.org/article/f09d1ccc1e78413580faa11fd3097f97
Autor:
Pushpa Pandiyan, Natarajan Bhaskaran, Mangge Zou, Elizabeth Schneider, Sangeetha Jayaraman, Jochen Huehn
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Mammals co-exist with resident microbial ecosystem that is composed of an incredible number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident microbes and mucosal surfaces, both parties are in continuous and compl
Externí odkaz:
https://doaj.org/article/27acb61c4a8b479496ce70825475681b
Autor:
Natarajan Bhaskaran, Cheriese Quigley, Clarissa Paw, Shivani Butala, Elizabeth Schneider, Pushpa Pandiyan
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Interactions between mucosal tissues and commensal microbes control appropriate host immune responses and inflammation, but very little is known about these interactions. Here we show that the depletion of resident bacteria using antibiotics (Abx) ca
Externí odkaz:
https://doaj.org/article/e652d6ea3ec64c4197bf37a23f3a7693
Autor:
Natarajan Bhaskaran, Zhihui Liu, Senthil S. Saravanamuthu, Chunhua Yan, Ying Hu, Lijin Dong, Peggy Zelenka, Lixin Zheng, Vassili Bletsos, Rachel Harris, Brenna Harrington, Aaron Weinberg, Carol J. Thiele, Fengchun Ye, Pushpa Pandiyan
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
While T helper (Th) cells play a crucial role in host defense, an imbalance in Th effector subsets due to dysregulation in their differentiation and expansion contribute to inflammatory disorders. Here, we show that Casz1, whose function is previousl
Externí odkaz:
https://doaj.org/article/9c0d06415c0a4ad5a56bb39cba3882f5