Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Purvish Patel"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Publikováno v:
Organic & Biomolecular Chemistry. 20:5933-5937
Quaternary α-(hetero)arylnitriles are desirable biologically relevant products, however the existing methods for their synthesis can be unselective or require the use of undesirable reagents, such as cyanide salts. Herein we report a one-pot method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce82ee5ba0950b63b791d8708f05ccd
https://doi.org/10.1039/d2ob00236a
https://doi.org/10.1039/d2ob00236a
Publikováno v:
Kidney International. 103:1001-1002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27226b0ab64cf0c5699f3fd0c036a9b6
https://doi.org/10.1016/j.kint.2022.12.016
https://doi.org/10.1016/j.kint.2022.12.016
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Publikováno v:
Journal of the American Chemical Society. 141:19257-19262
Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN). MPMN is a bench-stable, carbon-bound electrophilic CN rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc272816b73c7177e7cdaae3a1a75e0
https://doi.org/10.1021/jacs.9b11208
https://doi.org/10.1021/jacs.9b11208
Autor:
Sophie A. L. Rousseaux, Purvish Patel
Publikováno v:
Synlett. 31:492-496
α-Aryl amines are prevalent in pharmaceutically active compounds and natural products. Herein, we describe a Ni-catalyzed protocol for their synthesis from readily available α-aryl ethers. While α-aryl ethers have been used as electrophiles in Ni-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32acb7104d58140a84712c94eee3746d
https://doi.org/10.1055/s-0039-1690718
https://doi.org/10.1055/s-0039-1690718
Publikováno v:
Angewandte Chemie International Edition. 58:10300-10304
The efficient preparation of nitrile-containing building blocks is of interest due to their utility as synthetic intermediates and their prevalence in pharmaceuticals. As a result, significant efforts have been made to develop methods to access these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39de7e3f238abdb6a7565409659bd0ee
https://doi.org/10.1002/anie.201903215
https://doi.org/10.1002/anie.201903215
Autor:
Deborah Persaud, Allison L. Agwu, Lilly V. Siems, Ya Hui Chen, Adit Dhummakupt, Purvish Patel, Hao Zhang, Aleisha Collinson-Streng, Dolly Singh, Thuy Anderson
Publikováno v:
The Journal of Infectious Diseases. 219:80-88
BACKGROUND: High-level expression of the Fcγ receptor, CD32(hi), on CD4(+) T cells was associated with enhanced human immunodeficiency virus (HIV) infection of the latent reservoir in a study of adults receiving antiretroviral therapy. We tested the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d61ae63702e9b8b5f9fcdb4f883346
https://doi.org/10.1093/infdis/jiy461
https://doi.org/10.1093/infdis/jiy461
The efficient preparation of nitrile-containing building blocks is of interest due to their utility as synthetic intermediates and their prevalence in pharmaceuticals. As a result, significant efforts have been made to develop methods to access these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014c60e6e95aaef43ab4f22e1561ff6a
https://doi.org/10.26434/chemrxiv.7834940
https://doi.org/10.26434/chemrxiv.7834940
Autor:
Reed, Mark A., Purvish, Patel
Publikováno v:
Synfacts; May2024, Vol. 20 Issue 5, p462-462, 1p