Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Purushothama Rao"'
Autor:
Rita M. Meganck, Caitlin E. Edwards, Michael L. Mallory, Rhianna E. Lee, Hong Dang, Alexis B. Bailey, Jason A. Wykoff, Samuel C. Gallant, Deanna R. Zhu, Boyd L. Yount, Takafumi Kato, Kendall M. Shaffer, Satoko Nakano, Anne Marie Cawley, Vishwaraj Sontake, Jeremy R. Wang, Robert S. Hagan, Melissa B. Miller, Purushothama Rao Tata, Scott H. Randell, Longping V. Tse, Camille Ehre, Kenichi Okuda, Richard C. Boucher, Ralph S. Baric
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114076- (2024)
Summary: The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the emergence of novel variants of concern (VOCs) that replace ancestral strains. Here, we dissect the complex selective pressures by evaluating variant fitness
Externí odkaz:
https://doaj.org/article/f8f7061e966c4c31ad0d17d536355449
Autor:
Arvind Konkimalla, Satoshi Konishi, Yoshihiko Kobayashi, Preetish Kadur Lakshminarasimha Murthy, Lauren Macadlo, Ananya Mukherjee, Zachary Elmore, So-Jin Kim, Ann Marie Pendergast, Patty J. Lee, Aravind Asokan, Lars Knudsen, Jose Javier Bravo-Cordero, Aleksandra Tata, Purushothama Rao Tata
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105114- (2022)
Summary: Epithelial cells of diverse tissues are characterized by the presence of a single apical domain. In the lung, electron microscopy studies have suggested that alveolar type-2 epithelial cells (AT2s) en face multiple alveolar sacs. However, ap
Externí odkaz:
https://doaj.org/article/73d87ff05eac443eba891db8672a1af3
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101447- (2022)
Summary: Alveolar type 2 cells (AT2s) serve as stem cells of the alveoli and restore cell numbers after injury. Here, we describe a detailed protocol for the isolation, purification, and culture of murine and human AT2s. We have developed chemically
Externí odkaz:
https://doaj.org/article/009cecbc2f6b4ac6b7fde84de48b867f
Autor:
Vardhman Kumar, Sajeesh Kumar Madhurakkat Perikamana, Aleksandra Tata, Jiaul Hoque, Anna Gilpin, Purushothama Rao Tata, Shyni Varghese
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The gas exchange units of the lung, the alveoli, are mechanically active and undergo cyclic deformation during breathing. The epithelial cells that line the alveoli contribute to lung function by reducing surface tension via surfactant secretion, whi
Externí odkaz:
https://doaj.org/article/febf2b49087c4a90bf6ebcf59346706f
Autor:
Lihua Wang, Ergang Wang, Jorge Prado Balcazar, Zhenzhen Wu, Kun Xiang, Yi Wang, Qiang Huang, Marcos Negrete, Kai‐Yuan Chen, Wei Li, Yujie Fu, Anders Dohlman, Robert Mines, Liwen Zhang, Yoshihiko Kobayashi, Tianyi Chen, Guizhi Shi, John Paul Shen, Scott Kopetz, Purushothama Rao Tata, Victor Moreno, Charles Gersbach, Gregory Crawford, David Hsu, Emina Huang, Pengcheng Bu, Xiling Shen
Publikováno v:
Advanced Science, Vol 8, Iss 19, Pp n/a-n/a (2021)
Abstract Colorectal cancer (CRC) metastasizes mainly to the liver, which accounts for the majority of CRC‐related deaths. Here it is shown that metastatic cells undergo specific chromatin remodeling in the liver. Hepatic growth factor (HGF) induces
Externí odkaz:
https://doaj.org/article/d9e4ca4741b44963bbd7506d05a7e116
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 657-666 (2019)
Summary: Inflammatory responses are known to facilitate tissue recovery following injury. However, the precise mechanisms that enhance lung alveolar regeneration remain unclear. Here, using an organoid-based screening assay, we find that interleukin-
Externí odkaz:
https://doaj.org/article/77dff926521b4266b198ee2e2e444bde
Autor:
Shintaro Ide, Yoshihiko Kobayashi, Kana Ide, Sarah A Strausser, Koki Abe, Savannah Herbek, Lori L O'Brien, Steven D Crowley, Laura Barisoni, Aleksandra Tata, Purushothama Rao Tata, Tomokazu Souma
Publikováno v:
eLife, Vol 10 (2021)
Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans. Using single-cell transcriptomic and mouse genetic appro
Externí odkaz:
https://doaj.org/article/00dbe0c73bae414ca6bbc0e4be36568e
Autor:
Etai Sapoznik, Bo-Jui Chang, Jaewon Huh, Robert J Ju, Evgenia V Azarova, Theresa Pohlkamp, Erik S Welf, David Broadbent, Alexandre F Carisey, Samantha J Stehbens, Kyung-Min Lee, Arnaldo Marín, Ariella B Hanker, Jens C Schmidt, Carlos L Arteaga, Bin Yang, Yoshihiko Kobayashi, Purushothama Rao Tata, Rory Kruithoff, Konstantin Doubrovinski, Douglas P Shepherd, Alfred Millett-Sikking, Andrew G York, Kevin M Dean, Reto P Fiolka
Publikováno v:
eLife, Vol 9 (2020)
We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary objective to improve the resolution, field of view, and usability over previous variants. Owing to its high numerical aperture optics, this microscope achieves lat
Externí odkaz:
https://doaj.org/article/2e2ea231dd3f469fb756c32b4e680715
Autor:
Tallapragada Padmavathi, Rayavarapu Bhargavi, Purushothama Rao Priyanka, Naige Ranganath Niranjan, Pogakul Veerabhadrappa Pavitra
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 16, Iss 2, Pp 357-362 (2018)
Probiotics are the healthy living bacteria when administered in adequate amounts confers health benefits in the host. The main objective of present study was to screen the bacteria for potential probiotic characters and enzyme production. The probiot
Externí odkaz:
https://doaj.org/article/7c830b6a76714dc18ad50cecf4039684
Autor:
Akiyoshi Uezu, Erin Hisey, Yoshihiko Kobayashi, Yudong Gao, Tyler WA Bradshaw, Patrick Devlin, Ramona Rodriguiz, Purushothama Rao Tata, Scott Soderling
Publikováno v:
eLife, Vol 8 (2019)
Human mutations in the dystroglycan complex (DGC) result in not only muscular dystrophy but also cognitive impairments. However, the molecular architecture critical for the synaptic organization of the DGC in neurons remains elusive. Here, we report
Externí odkaz:
https://doaj.org/article/962ab3557d38497e91e4e12fb85d02bf