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Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming
Autor:
Daniel J Ford, Henri M. H. Spronk, Wenyu Liu, Vishnu M. Sasi, Colin J. Jackson, Tilman M. Hackeng, Nisharnthi M Duggan, Pedro Pereira, Hiroaki Suga, Stijn M. Agten, Anneliese S. Ashhurst, Rene van Oerle, Jorge Ripoll-Rozada, Richard J. Payne, Joe A. Kaczmarski, Leo Corcilius, Toby Passioura, Sarah E. Fry
Publikováno v:
Journal of Medicinal Chemistry, 64(11), 7853-7876. American Chemical Society
The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa), an initiator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0a2fcd6f50b94b3bfc83aa64363fc4
https://doi.org/10.1021/acs.jmedchem.1c00651
https://doi.org/10.1021/acs.jmedchem.1c00651
