Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Purnima P. Desai"'
Autor:
Purnima P. Desai, Milos D. Ikonomovic, Eric E. Abrahamson, Ronald L. Hamilton, Barbara A. Isanski, Caroline E. Hope, William E. Klunk, Steven T. DeKosky, M. Ilyas Kamboh
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 574-582 (2005)
Apolipoprotein D (apoD) is elevated in Alzheimer's disease (AD) cortex, localizing to cells, blood vessels, and neuropil deposits (plaques). The role of apoD in AD pathology and the extent of its co-distribution with diffuse (amorphous) and compact (
Externí odkaz:
https://doaj.org/article/afa7bb8974fa4083813bdca306560051
Autor:
Caroline E. Hope, William E. Klunk, Ronald L. Hamilton, Barbara A. Isanski, Steven T. DeKosky, M. Ilyas Kamboh, Milos D. Ikonomovic, Purnima P. Desai, Eric E. Abrahamson
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 574-582 (2005)
Apolipoprotein D (apoD) is elevated in Alzheimer's disease (AD) cortex, localizing to cells, blood vessels, and neuropil deposits (plaques). The role of apoD in AD pathology and the extent of its co-distribution with diffuse (amorphous) and compact (
Autor:
Hugh C. Hendrie, Jill R. Murrell, Steven T. DeKosky, Rebecca M. Evans, M. Ilyas Kamboh, Purnima P. Desai
Publikováno v:
American Journal of Medical Genetics. :98-101
Apolipoprotein D (APOD, gene; apoD, protein) is involved in neuroregenerative and neurodegenerative processes, and is upregulated in late-onset Alzheimer disease (AD) patients compared to nondemented controls. No genetic association studies have yet
Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
Publikováno v:
Neuroscience Letters. 328:9-12
Alzheimer's disease (AD) is a complex, multifactorial disorder, with many genetic and environmental factors implicated in disease onset and pathology. Increasing evidence points to a link between brain cholesterol turnover and AD. The CYP46 gene enco
Autor:
Margaret Kenney, Steven T. DeKosky, Ayla Ozturk, Ryan L. Minster, Purnima P. Desai, Candace M. Kammerer, M. Ilyas Kamboh
Publikováno v:
Neurobiology of aging. 27(10)
In addition to genetic effects on disease risk, age-at-onset (AAO) of Alzheimer's disease (AD) is also genetically controlled. Using AAO as a covariate, a linkage signal for AD has been detected on chromosome 14q32 near the alpha1-antichymotrypsin (A
Publikováno v:
Neuroscience letters. 379(3)
BDNF is a functional candidate gene for AD, owing to its role in neuronal development and survival. The Val66Met (G196A), along with another C270T polymorphism has been associated with AD, however, the effects seem to be inconsistent across studies.
Publikováno v:
Neurobiology of aging. 26(8)
Linkage studies suggest the presence of putative risk and/or age-at-onset genes for Alzheimer's disease on Chromosome 10. Recently, a genomic converging approach using a combination of linkage, expression and association studies has reported signific
Autor:
Reza Zarnegar, Haider Mehdi, Qi Chen, Stephen C. Strom, Purnima P. Desai, Cara Nestlerode, Susan Manzi, M. Ilyas Kamboh, Franklin A. Bontempo
Publikováno v:
European journal of biochemistry. 270(2)
Human beta2-glycoprotein I (beta2GPI), also known as apolipoprotein H, has been implicated in haemostasis and the production of anti-phospholipid antibodies. There is a wide range of interindividual variation in beta2GPI plasma levels that is thought
Publikováno v:
Atherosclerosis. 163(2)
Apolipoprotein D (APOD, gene; apoD, protein) is a plasma high-density lipoprotein (HDL)—associated glycoprotein, with a putative role in the cholesterol (CHOL) transport pathway. An apoD protein polymorphism has been previously reported by us. The
Autor:
Mary Ganguli, Purnima P. Desai, Qi Chen, Ayla Ozturk, Charles F. Reynolds, Steven T. DeKosky, Robert D. Nebes, Ryan L. Minster, M. Ilyas Kamboh
Publikováno v:
Neurobiology of Aging. 25:S512-S513