Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Purnendu K. Nayak"'
Autor:
Mohammad Al-Sayah, Dennis Leung, Purnendu K. Nayak, Amin Famili, Debby P. Chang, Meenakshi Goel
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 165:185-192
Poly (lactic-co-glycolic acid) (PLGA), a biocompatible and biodegradable polymer, is one of the most commonly used vehicles for controlled-release (CR) implantable dosage forms. Drug molecules formulated in such CR vehicles are released slowly over a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68524ed470988c3fd80ba14f23107f97
https://doi.org/10.1016/j.ejpb.2021.05.008
https://doi.org/10.1016/j.ejpb.2021.05.008
Autor:
Daniel Kammerer, Linda Jiang, Michelle Tai, Barthélemy Demeule, Miguel Saggu, Nina Xiao, Purnendu K. Nayak, Anthony Tomlinson
Publikováno v:
Journal of pharmaceutical sciences. 110(3)
In recent years, there has been increased scrutiny on the presence and formation of product-related particles in biopharmaceutical formulations. These types of particles, originating from the degradation of the active pharmaceutical ingredient or the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affc21cfdbf6b4e77586c4ece1e8ed06
https://pubmed.ncbi.nlm.nih.gov/33271136
https://pubmed.ncbi.nlm.nih.gov/33271136
Publikováno v:
Molecular pharmaceutics. 17(9)
Maintenance of protein stability during manufacture, storage, and delivery is necessary for the successful development of a drug product. Herein, the utility of two compatible solutes-ectoine and hydroxyectoine-in stabilizing a model protein labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a264bf77e312a364291b91b05bce584e
https://pubmed.ncbi.nlm.nih.gov/32672979
https://pubmed.ncbi.nlm.nih.gov/32672979
Autor:
Norman J. Wagner, Jean Ross, Abraham M. Lenhoff, Stijn H.S. Koshari, Isidro E. Zarraga, Purnendu K. Nayak, Karthikan Rajagopal
Publikováno v:
Molecular Pharmaceutics. 14:546-553
Protein-stabilizer microheterogeneity is believed to influence long-term protein stability in solid-state biopharmaceutical formulations and its characterization is therefore essential for the rational design of stable formulations. However, the spat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cbff5683dcea0de12b23c0cc38a47e
https://doi.org/10.1021/acs.molpharmaceut.6b00940
https://doi.org/10.1021/acs.molpharmaceut.6b00940
Autor:
Lokesh Kumar, Karthik Balakrishna Chandrababu, Shenbaga Moorthy Balakrishnan, Elizabeth M Topp, Debby P. Chang, Isidro E. Zarraga, Andrea Allmendinger, Purnendu K. Nayak, Benjamin T. Walters
Publikováno v:
Molecular pharmaceutics. 16(11)
Solid-state hydrogen-deuterium exchange with mass spectrometry (ssHDX-MS) was evaluated as an analytical method to rapidly screen and select an optimal lyophilized fragment antigen binding protein (Fab) formulation and the optimal lyophilization cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47f157334df7cf12b7eb1e28178a5b3
https://pubmed.ncbi.nlm.nih.gov/31568722
https://pubmed.ncbi.nlm.nih.gov/31568722
Autor:
Alavattam Sreedhara, Saeed Izadi, Robert F. Kelley, Thomas W. Patapoff, Karthikan Rajagopal, Purnendu K. Nayak, Jennifer Y. Zhang, Debby P. Chang
Publikováno v:
Molecular pharmaceutics. 16(1)
The preparation of PLGA rods for sustained release applications via a hot-melt extrusion process employs heat and mechanical shear. Understanding protein stability and degradation mechanisms at high temperature in the solid state is therefore importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892641dfec938de66c955045c71e59b8
https://pubmed.ncbi.nlm.nih.gov/30525659
https://pubmed.ncbi.nlm.nih.gov/30525659
Autor:
Shalini Burra, Abraham M. Lenhoff, Yun Liu, Norman J. Wagner, Isidro E. Zarraga, Karthikan Rajagopal, Purnendu K. Nayak, Stijn H.S. Koshari
Publikováno v:
Molecular pharmaceutics. 16(1)
Lyophilized and spray-dried biopharmaceutical formulations are used to provide long-term stability for storage and transport, but questions remain about the molecular structure in these solid formulations and how this structure may be responsible for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823b6dbdb3b9ba28094626178f160387
https://pubmed.ncbi.nlm.nih.gov/30484319
https://pubmed.ncbi.nlm.nih.gov/30484319
Publikováno v:
Physical chemistry chemical physics : PCCP. 15(6)
The wide diversity of room-temperature ionic liquids (ILs) presents opportunities for studying, and controlling, polymer phase behavior. We have examined the phase behavior of poly(N-isopropyl acrylamide) (PNIPAM) in imidazolium ILs and their mixture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bee9c3e2d661cb1b90ce60c1db450c
https://pubmed.ncbi.nlm.nih.gov/23299223
https://pubmed.ncbi.nlm.nih.gov/23299223