A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.

Autor: Crompton, Michael^1,2, Purnell, Tom¹, Tyrer, Hayley E.¹, Parker, Andrew¹, Ball, Greg¹, Hardisty-Hughes, Rachel E.¹, Gale, Richard¹, Williams, Debbie¹, Dean, Charlotte H.^1,3, Simon, Michelle M.¹, Mallon, Ann-Marie¹, Wells, Sara⁴, Bhutta, Mahmood F.^1,2,5, Burton, Martin J.², Tateossian, Hilda¹ h.tateossian@har.mrc.ac.uk, Brown, Steve D. M.¹ s.brown@har.mrc.ac.uk

Publikováno v: PLoS Genetics. 8/14/2017, Vol. 13 Issue 8, p1-28. 28p.

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HIF–VEGF Pathways Are Critical for Chronic Otitis Media in Junbo and Jeff Mouse Mutants

Autor: Avraham, Karen B., Cheeseman, Michael T., Tyrer, Hayley, Williams, Debbie, Hough, Tertius A., Pathak, Paras, Romero, Maria R., Hilton, Helen, Bali, Sulzhan, Parker, Andrew, Vizor, Lucie, Purnell, Tom, Vowell, Kate, Wells, Sara, Bhutta, Mahmood F., Potter, Paul K., Brown, Steve D. M.

Publikováno v: PLoS Genetics, Vol 7, Iss 10, p e1002336 (2011)
PLoS Genetics
Cheeseman, M T, Tyrer, H E, Williams, D, Hough, T A, Pathak, P, Romero, M R, Hilton, H, Bali, S, Parker, A, Vizor, L, Purnell, T, Vowell, K, Wells, S, Bhutta, M F, Potter, P K & Brown, S D M 2011, ' HIF-VEGF Pathways Are Critical for Chronic Otitis Media in Junbo and Jeff Mouse Mutants ', PLoS Genetics, vol. 7, no. 10, e1002336 . https://doi.org/10.1371/journal.pgen.1002336

Otitis media with effusion (OME) is the commonest cause of hearing loss in children, yet the underlying genetic pathways and mechanisms involved are incompletely understood. Ventilation of the middle ear with tympanostomy tubes is the commonest surgi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7713ad57f650ccca1e831e6fa37d926a

Cellular Immune Response against Nontypeable Haemophilus influenzaeInfecting the Preinflamed Middle Ear of the JunboMouse

Autor: Vikhe, Pratik P., Purnell, Tom, Brown, Steve D. M., Hood, Derek W.

Publikováno v: Infection and Immunity; September 2019, Vol. 87 Issue: 12