Endocardial role in arrhythmias induced by acute ventricular stretch and the involvement of Purkinje fibres, in isolated rat hearts

Autor: Miriam Hurley, Sarbjot Kaur, Richard Walton, Amelia Power, Michel Haïssaguerre, Olivier Bernus, Marie-Louise Ward, Ed White

Publikováno v: Current Research in Physiology, Vol 6, Iss , Pp 100098- (2023)

Purkinje fibres (PFs) play an important role in some ventricular arrhythmias and acute ventricular stretch can evoke mechanically-induced arrhythmias. We tested whether PFs and specifically TRPM4 channels, play a role in these mechanically-induced ar

Externí odkaz: https://doaj.org/article/73a17cc8e966401b91bca55c5efa4e90

Syncope in a young man: Role of Purkinje fibres in idiopathic ventricular fibrillation

Autor: Claire A. Martin, PhD, Laurence Nunn, FRCP, Pier D. Lambiase, PhD FHRS

Publikováno v: Indian Pacing and Electrophysiology Journal, Vol 17, Iss 4, Pp 113-115 (2017)

A young man suffered cardiac arrests with polymorphic ventricular tachycardia (PVT) and ventricular fibrillation (VF) triggered by ventricular premature contractions (PVCs). The arrhythmia was resistant to anti-arrhythmics, so after ICD implantation

Externí odkaz: https://doaj.org/article/e9bcdf41aafc46dc986d78fac36565d2

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Diagnosis and Management of Complex Reentrant Arrhythmias Involving the His-Purkinje System

Autor: Satoshi Higuchi, Penelope A. Boyden, Raphael K. Sung, Melvin M. Scheinman

Publikováno v: Arrhythmia & electrophysiology review, vol 10, iss 3
Arrhythmia & Electrophysiology Review
Arrhythmia & Electrophysiology Review, Vol 10, Iss 3, Pp 190-197 (2021)

The His-Purkinje system is a network of bundles and fibres comprised of specialised cells that allow for coordinated, synchronous activation of the ventricles. Although the histology and physiology of the His-Purkinje system have been studied for mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6bb80952680b80f5bc70fa725c1077
https://escholarship.org/uc/item/0g27b1c4

In-silico Trials for Drug Safety and Efficacy Assessment Using a Novel Human Purkinje Fibre Model

Autor: S. Billiald-Desquand, Elisa Passini, C. Dusserre, Cristian Trovato, Blanca Rodriguez

Publikováno v: CinC

In silico trials using multiscale and biophysically-detailed human models have proven to be a new powerful tool for proarrhythmic risk prediction. Our goal is to evaluate the consistency between in silico results using a novel human Purkinje model an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b225955d0b6bae4443e90bc74b8cf9e0
https://doi.org/10.22489/cinc.2020.361