Zobrazeno 1 - 10
of 4 814
pro vyhledávání: '"Purinergic signalling"'
Autor:
Catarina Bessa-Andrês, Rui Pinto-Cardoso, Karyna Tarasova, Ana Luísa Pereira-Gonçalves, Joana Maria Gaio-Ferreira-Castro, Liliana S. Carvalho, Maria Adelina Costa, Fátima Ferreirinha, Ana Canadas-Sousa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Paulo Correia-de-Sá, José Bernardo Noronha-Matos
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Background Mechanical stimulation (MS) significantly increases the release of adenine and uracil nucleotides from bone marrow-derived mesenchymal stem cells (BM-MSCs) undergoing osteogenic differentiation. Released nucleotides acting via ion
Externí odkaz:
https://doaj.org/article/b4b4090c36a44529acbce7c308244895
Autor:
Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger, Christian Madry
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ efflux as a key signaling event,
Externí odkaz:
https://doaj.org/article/208476be51d34f6da4991c7759669750
Autor:
András Iring, Mária Baranyi, Bernadett Iring-Varga, Paula Mut-Arbona, Zsuzsanna T. Gál, Dorina Nagy, László Hricisák, János Varga, Zoltán Benyó, Beáta Sperlágh
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Peripheral blood oxygen monitoring via chemoreceptors in the carotid body (CB) is an integral function of the autonomic cardiorespiratory regulation. The presence of the purinergic P2Y12 receptor (P2Y12R) has been implicated in CB
Externí odkaz:
https://doaj.org/article/ee730e58e3444a448cc7d170b40305a3
Autor:
Fiona D. McBryde
Publikováno v:
Experimental Physiology, Vol 109, Iss 4, Pp 470-471 (2024)
Externí odkaz:
https://doaj.org/article/97c916599266433f8cff1e01ec2ea1e6
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/eab009e983894fbf979480724c300e97
Autor:
Divyeshz Thakku Sivakumar, Krishi Jain, Noura Alfehaid, Yitao Wang, Xinchen Teng, Wolfgang Fischer, Tobias Engel
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6894 (2024)
Epilepsy is one of the most common neurological diseases worldwide. Anti-seizure medications (ASMs) with anticonvulsants remain the mainstay of epilepsy treatment. Currently used ASMs are, however, ineffective to suppress seizures in about one third
Externí odkaz:
https://doaj.org/article/61175591e1a3459bbefd809c4c2ed440
Autor:
José Bernardo Noronha-Matos, Rui Pinto-Cardoso, Catarina Bessa-Andrês, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Maria Adelina Costa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Endogenously released adenine and uracil nucleotides favour the osteogenic commitment of bone marrow-derived mesenchymal stromal cells (BM-MSCs) through the activation of ATP-sensitive P2X7 and UDP-sensitive P2Y6 receptors. Yet, t
Externí odkaz:
https://doaj.org/article/95ea55a1f00f46fca819e6b29a679372
Autor:
Hangxiu Che, Yaqun Wang, Jinhui Lao, Yixin Deng, Chirui Xu, Hanxiao Yin, Zheng Tang, Yonghong Huang, Hong Xu
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 recept
Externí odkaz:
https://doaj.org/article/5b67b700046a4f969ae6b65c6ab3e13f
Autor:
Francisco Ciruela, Kenneth A. Jacobson
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ebd842e1f2a244169bb62dd0c9bc6192
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