Zobrazeno 1 - 10
of 9 654
pro vyhledávání: '"Purinergic receptor"'
Autor:
Jiratchaya Srisutha, Ippei Watari, Masato Akakura, Minami Watanabe, Chidsanu Changsiripun, Takashi Ono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Type 2 diabetes mellitus (T2DM) is a chronic inflammatory disease that can compromise the functioning of various organs, including the salivary glands (SG). The purinergic system is one of the most important inflammatory pathways in T2DM con
Externí odkaz:
https://doaj.org/article/5514ea2733a84a40b0be9bd7b353e31e
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110967- (2024)
Purpose: Post-stroke cognitive impairment (PSCI) is a common complication of ischemic stroke episodes. Memory impairment is an important component of the poststroke cognitive syndrome. Microglial activation plays a critical role in stroke-induced neu
Externí odkaz:
https://doaj.org/article/22bf06ee674c4626ba79e285883ac91a
Autor:
Maria Pina Notarangelo, Letizia Penolazzi, Elisabetta Lambertini, Simonetta Falzoni, Pasquale De Bonis, Cristina Capanni, Francesco Di Virgilio, Roberta Piva
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
A comprehensive understanding of the molecules that play key roles in the physiological and pathological homeostasis of the human intervertebral disc (IVD) remains challenging, as does the development of new therapeutic treatments. We recently found
Externí odkaz:
https://doaj.org/article/9535fd74f6e64ed9908505704d26553a
Autor:
David Hough, Alice R. Mao, Michael Aman, Reymundo Lozano, Constance Smith-Hicks, Veronica Martinez-Cerdeno, Michael Derby, Zachary Rome, Niel Malan, Robert L. Findling
Publikováno v:
Annals of General Psychiatry, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background There is a critical need for effective treatment of the core symptoms of autism spectrum disorder (ASD). The purinergic antagonist suramin may improve core symptoms through restoration of normal mitochondrial function and reductio
Externí odkaz:
https://doaj.org/article/1743603b9ad44d018904136d758c5761
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new therapies. New migraine therapeutics are needed to address the current deficiencies that exist in the efficacy and adherence rate o
Externí odkaz:
https://doaj.org/article/b546ac27c15946b2960427b79b569952
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Extracellular ATP and adenosine are neuromodulators that regulate numerous neuronal functions in the brain. Neuronal activity and brain insults such as ischemic and traumatic injury upregulate these neuromodulators, which exert their effects by activ
Externí odkaz:
https://doaj.org/article/510ce85823cb4570a6016bb9be614d22
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 440-453 (2025)
Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau. Targeting amyloid-beta plaques has been a primary direction for dev
Externí odkaz:
https://doaj.org/article/a46dc335b1144e9a8e2df022f0989216
Autor:
Bo Yang, Nengwei Yu
Publikováno v:
Brain Research Bulletin, Vol 204, Iss , Pp 110800- (2023)
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2. This review discusses whether traditional Chinese medicine target P2 receptors in neuropathic pai
Externí odkaz:
https://doaj.org/article/f576a832c98e45a6a9e58e3bf5415bd9
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: As a member of the purinergic receptor family, divalent cation-regulated ionotropic P2X7 (P2rx7) plays a role in the pathophysiology of psychiatric disorders. This study aimed to investigate whether the effects of acute zinc administratio
Externí odkaz:
https://doaj.org/article/08b2458614314e8a9175c749d53ca375
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Despite the rapid development of therapeutic strategies in cancer treatment, metastasis remains the major cause of cancer-related death and scientific challenge. Epithelial-Mesenchymal Transition (EMT) plays a crucial role in cancer invasion
Externí odkaz:
https://doaj.org/article/b562a2f892684208b410e97c06458967