De novo and salvage purine synthesis pathways across tissues and tumors.

Autor: Tran DH; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Kim D; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Kesavan R; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Brown H; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Dey T; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Soflaee MH; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Vu HS; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Tasdogan A; Department of Dermatology, University Hospital Essen & German Cancer Consortium, Partner Site, Essen, Germany., Guo J; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Bezwada D; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Al Saad H; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Cai F; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Solmonson A; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Rion H; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Chabatya R; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Merchant S; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Manales NJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Tcheuyap VT; Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Mulkey M; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Mathews TP; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Brugarolas J; Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Morrison SJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Zhu H; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., DeBerardinis RJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Hoxhaj G; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: gerta.hoxhaj@utsouthwestern.edu.

Publikováno v: Cell [Cell] 2024 Jul 11; Vol. 187 (14), pp. 3602-3618.e20. Date of Electronic Publication: 2024 May 31.

Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse UCP1.

Autor: Musiol E; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany., Fromme T; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany.; EKFZ-Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Munich, Germany., Hau J; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany., Di Pizio A; Molecular Modeling Group, Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising, Germany.; Professorship of Chemoinformatics and Protein Modelling, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany., Klingenspor M; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany.; EKFZ-Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Munich, Germany.

Publikováno v: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2024 Sep; Vol. 240 (9), pp. e14209. Date of Electronic Publication: 2024 Jul 29.

Expanding the Available RNA Labeling Toolbox With CutA Nucleotidyltransferase for Efficient Transcript Labeling with Purine and Pyrimidine Nucleotide Analogs.

Autor: Tomecki R; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106, Warsaw, Poland.; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, Poland., Drazkowska K; Laboratory of Epitranscriptomics, Department of Environmental Microbiology and Biotechnology, Institute of Microbiology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Zwirki i Wigury 101, 02-089, Warsaw, Poland., Madaj R; Laboratory of Structural Bioinformatics, Institute of Evolutionary Biology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Zwirki i Wigury 101, 02-089, Warsaw, Poland., Mamot A; Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany., Dunin-Horkawicz S; Laboratory of Structural Bioinformatics, Institute of Evolutionary Biology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Zwirki i Wigury 101, 02-089, Warsaw, Poland.; Department of Protein Evolution, Max Planck Institute for Biology Tübingen, Max-Planck-Ring 5, 72076, Tübingen, Germany., Sikorski PJ; Laboratory of Epitranscriptomics, Department of Environmental Microbiology and Biotechnology, Institute of Microbiology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Zwirki i Wigury 101, 02-089, Warsaw, Poland.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Aug 01; Vol. 25 (15), pp. e202400202. Date of Electronic Publication: 2024 Jul 11.

An inosine triphosphate pyrophosphatase safeguards plant nucleic acids from aberrant purine nucleotides.

Autor: Straube H; Department of Molecular Nutrition and Biochemistry of Plants, Leibniz Universität Hannover, Hannover, 30419, Germany., Straube J; Department of Molecular Plant Breeding, Leibniz Universität Hannover, Hannover, 30419, Germany., Rinne J; Department of Molecular Nutrition and Biochemistry of Plants, Leibniz Universität Hannover, Hannover, 30419, Germany., Fischer L; Department of Molecular Nutrition and Biochemistry of Plants, Leibniz Universität Hannover, Hannover, 30419, Germany., Niehaus M; Department of Molecular Nutrition and Biochemistry of Plants, Leibniz Universität Hannover, Hannover, 30419, Germany., Witte CP; Department of Molecular Nutrition and Biochemistry of Plants, Leibniz Universität Hannover, Hannover, 30419, Germany., Herde M; Department of Molecular Nutrition and Biochemistry of Plants, Leibniz Universität Hannover, Hannover, 30419, Germany.

Publikováno v: The New phytologist [New Phytol] 2023 Mar; Vol. 237 (5), pp. 1759-1775. Date of Electronic Publication: 2022 Dec 29.

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing.

Autor: Zarou MM; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Rattigan KM; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Sarnello D; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Shokry E; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Dawson A; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Ianniciello A; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Dunn K; Paul O'Gorman Leukaemia Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G12 0ZD, UK., Copland M; Paul O'Gorman Leukaemia Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G12 0ZD, UK., Sumpton D; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Vazquez A; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. avazque1@protonmail.com., Helgason GV; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. vignir.helgason@glasgow.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Mar 02; Vol. 15 (1), pp. 1931. Date of Electronic Publication: 2024 Mar 02.