Interaction of Tri-Cyclic Nucleobase Analogs with Enzymes of Purine Metabolism: Xanthine Oxidase and Purine Nucleoside Phosphorylase.

Autor: Stachelska-Wierzchowska A; Department of Physics and Biophysics, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 4 Oczapowskiego St., PL-10-719 Olsztyn, Poland., Narczyk M; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, PL-02-093 Warsaw, Poland., Wierzchowski J; Department of Physics and Biophysics, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 4 Oczapowskiego St., PL-10-719 Olsztyn, Poland., Bzowska A; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, PL-02-093 Warsaw, Poland., Wielgus-Kutrowska B; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, PL-02-093 Warsaw, Poland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 27; Vol. 25 (19). Date of Electronic Publication: 2024 Sep 27.

Prevalence of S-methyl-5'-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer: A Tissue Microarray Study on 13,067 Tumors From 149 Different Tumor Types.

Autor: Gorbokon N; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Wößner N; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Lennartz M; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Dwertmann Rico S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Kind S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Reiswich V; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Viehweger F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Lutz F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Fraune C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Luebke AM; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Hube-Magg C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Menz A; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Schlichter R; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Krech T; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Hinsch A; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Burandt E; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Sauter G; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Simon R; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Steurer S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Marx AH; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Institute of Pathology, Clinical Center Osnabrueck, Am Finkenhügel, Osnabrück, Germany., Lebok P; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Dum D; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Minner S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Jacobsen F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Clauditz TS; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Hackert T; Department of Pathology, Academic Hospital Fuerth, Jakob-Henle-Straße, Fürth, Germany., Uzunoǧlu FG; Department of Pathology, Academic Hospital Fuerth, Jakob-Henle-Straße, Fürth, Germany., Bubendorf L; Institute of Pathology, University Hospital Basel, Schönbeinstrasse, Basel, Switzerland., Bernreuther C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Kluth M; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.

Publikováno v: The American journal of surgical pathology [Am J Surg Pathol] 2024 Oct 01; Vol. 48 (10), pp. 1245-1258. Date of Electronic Publication: 2024 Aug 12.

MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors.

Autor: Chen S; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Hou J; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Jaffery R; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Guerrero A; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Fu R; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Shi L; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Zheng N; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Bohat R; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Egan NA; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Yu C; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Sharif S; Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas, USA., Lu Y; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., He W; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Wang S; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Gjuka D; Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA., Stone EM; Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA., Shah PA; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Rodon Ahnert J; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Chen T; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Liu X; Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas, USA., Bedford MT; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Xu H; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Peng W; Biology and Biochemistry, University of Houston, Houston, Texas, USA wpeng2@central.uh.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Sep 23; Vol. 12 (9). Date of Electronic Publication: 2024 Sep 23.

Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions.

Autor: Birder LA; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA. lbirder@pitt.edu.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA. lbirder@pitt.edu.; University of Pittsburgh School of Medicine, A 1217 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15217, USA. lbirder@pitt.edu., Wolf-Johnston A; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Ritov V; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Stern JNH; Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Arthur Smith Institute for Urology, Lake Success, NY, 11549, USA., Moldwin R; Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Arthur Smith Institute for Urology, Lake Success, NY, 11549, USA., Kuo HC; Department of Urology, Hualien Tzu Chi Hospital, Tzu Chi University, Hualien, Taiwan., Jackson EK; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.

Publikováno v: Scientific reports [Sci Rep] 2024 Sep 19; Vol. 14 (1), pp. 21898. Date of Electronic Publication: 2024 Sep 19.

Bacterial Purine Nucleoside Phosphorylases from Mesophilic and Thermophilic Sources: Characterization of Their Interaction with Natural Nucleosides and Modified Arabinofuranoside Analogues.

Autor: Bychek IA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Zenchenko AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Kostromina MA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Khisamov MM; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Solyev PN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Esipov RS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Mikhailov SN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Varizhuk IV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Publikováno v: Biomolecules [Biomolecules] 2024 Aug 27; Vol. 14 (9). Date of Electronic Publication: 2024 Aug 27.