First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase I dose exploration.

Autor: Rodon J; MD Anderson Cancer Center, Houston, USA. Electronic address: jrodon@mdanderson.org., Prenen H; University Hospital Antwerp, Edegem, Belgium., Sacher A; Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada., Villalona-Calero M; Department of Medical Oncology and Therapeutics Research, University of California, Irvine, USA., Penel N; Centre Oscar Lambret, Lille, France., El Helali A; Centre of Cancer Medicine, University of Hong Kong, Hong Kong, China., Rottey S; Ghent University Hospital, Ghent, Belgium., Yamamoto N; National Cancer Center Hospital, Tokyo, Japan., Ghiringhelli F; INSERM U866, Cancer Center Georges Francois Leclerc, Dijon, France., Goebeler ME; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany., Doi T; National Cancer Center Hospital East, Chiba, Japan., Postel-Vinay S; Institut Gustave Roussy, Villejuif, France; University College London Cancer Institute, London, UK., Lin CC; National Taiwan University Hospital, Taipei, Taiwan., Liu C; Amgen Inc., Thousand Oaks., Chuang CH; Amgen Inc., Thousand Oaks., Keyvanjah K; Amgen Inc., Thousand Oaks., Eggert T; Amgen Inc., Thousand Oaks., O'Neil BH; Community-Health Network, Indianapolis, USA.

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2024 Dec; Vol. 35 (12), pp. 1138-1147. Date of Electronic Publication: 2024 Sep 16.

Prevalence of S-methyl-5'-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer: A Tissue Microarray Study on 13,067 Tumors From 149 Different Tumor Types.

Autor: Gorbokon N; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Wößner N; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Lennartz M; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Dwertmann Rico S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Kind S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Reiswich V; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Viehweger F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Lutz F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Fraune C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Luebke AM; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Hube-Magg C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Menz A; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Schlichter R; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Krech T; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Hinsch A; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Burandt E; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Sauter G; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Simon R; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Steurer S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Marx AH; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Institute of Pathology, Clinical Center Osnabrueck, Am Finkenhügel, Osnabrück, Germany., Lebok P; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Dum D; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Minner S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Jacobsen F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Clauditz TS; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Hackert T; Department of Pathology, Academic Hospital Fuerth, Jakob-Henle-Straße, Fürth, Germany., Uzunoǧlu FG; Department of Pathology, Academic Hospital Fuerth, Jakob-Henle-Straße, Fürth, Germany., Bubendorf L; Institute of Pathology, University Hospital Basel, Schönbeinstrasse, Basel, Switzerland., Bernreuther C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany., Kluth M; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany.

Publikováno v: The American journal of surgical pathology [Am J Surg Pathol] 2024 Oct 01; Vol. 48 (10), pp. 1245-1258. Date of Electronic Publication: 2024 Aug 12.

Interaction of Tri-Cyclic Nucleobase Analogs with Enzymes of Purine Metabolism: Xanthine Oxidase and Purine Nucleoside Phosphorylase.

Autor: Stachelska-Wierzchowska A; Department of Physics and Biophysics, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 4 Oczapowskiego St., PL-10-719 Olsztyn, Poland., Narczyk M; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, PL-02-093 Warsaw, Poland., Wierzchowski J; Department of Physics and Biophysics, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 4 Oczapowskiego St., PL-10-719 Olsztyn, Poland., Bzowska A; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, PL-02-093 Warsaw, Poland., Wielgus-Kutrowska B; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, PL-02-093 Warsaw, Poland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 27; Vol. 25 (19). Date of Electronic Publication: 2024 Sep 27.

Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer.

Autor: Gorbokon N; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wößner N; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ahlburg V; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Plage H; Department of Urology, Charité Berlin, Berlin, Germany., Hofbauer S; Department of Urology, Charité Berlin, Berlin, Germany., Furlano K; Department of Urology, Charité Berlin, Berlin, Germany., Weinberger S; Department of Urology, Charité Berlin, Berlin, Germany., Bruch PG; Department of Urology, Charité Berlin, Berlin, Germany., Schallenberg S; Institute of Pathology, Charité Berlin, Berlin, Germany., Roßner F; Institute of Pathology, Charité Berlin, Berlin, Germany., Elezkurtaj S; Institute of Pathology, Charité Berlin, Berlin, Germany., Lennartz M; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Blessin NC; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Marx AH; Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany., Samtleben H; Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany., Fisch M; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rink M; Department of Urology, Marienhospital Hamburg, Hamburg, Germany., Slojewski M; Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland., Kaczmarek K; Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland., Ecke T; Department of Urology, Helios Hospital Bad Saarow, Bad Saarow, Germany., Klatte T; Department of Urology, Helios Hospital Bad Saarow, Bad Saarow, Germany., Koch S; Department of Pathology, Helios Hospital Bad Saarow, Bad Saarow, Germany., Adamini N; Department of Urology, Albertinen Hospital, Hamburg, Germany., Minner S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Simon R; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sauter G; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zecha H; Department of Urology, Charité Berlin, Berlin, Germany.; Department of Urology, Albertinen Hospital, Hamburg, Germany., Horst D; Institute of Pathology, Charité Berlin, Berlin, Germany., Schlomm T; Department of Urology, Charité Berlin, Berlin, Germany., Bubendorf L; Institute of Pathology, University Hospital Basel, Basel, Switzerland., Kluth M; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publikováno v: The journal of pathology. Clinical research [J Pathol Clin Res] 2025 Jan; Vol. 11 (1), pp. e70012.

MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors.

Autor: Chen S; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Hou J; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Jaffery R; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Guerrero A; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Fu R; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Shi L; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Zheng N; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Bohat R; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Egan NA; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Yu C; Biology and Biochemistry, University of Houston, Houston, Texas, USA., Sharif S; Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas, USA., Lu Y; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., He W; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Wang S; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Gjuka D; Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA., Stone EM; Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA., Shah PA; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Rodon Ahnert J; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Chen T; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Liu X; Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas, USA., Bedford MT; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Xu H; Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Peng W; Biology and Biochemistry, University of Houston, Houston, Texas, USA wpeng2@central.uh.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Sep 23; Vol. 12 (9). Date of Electronic Publication: 2024 Sep 23.