NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis

Autor: Arron, Sarah, South, AP, Purdie, KJ, Watt, SA, Haldenby, S, Den, NY, Dimon, MT, Arron, ST, Kluk, MJ, Aster, JC, McHugh, A

Publikováno v: Arron, Sarah; South, AP; Purdie, KJ; Watt, SA; Haldenby, S; Den, NY; et al.(2014). NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/07j1h9rs

Cutaneous SCC (cSCC) is the most frequently occuring skin cancer with metastatic potential and can manifest rapidly as a common side effect in patients receiving systemic kinase inhibitors. Here, we use massively parallel exome and targeted level seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::4a7837fce03a62bc7c9273adb23f9795
http://www.escholarship.org/uc/item/07j1h9rs

Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma.

Autor: Klein, Jason C.^1,2 (AUTHOR) jason.klein@cuanschutz.edu, Wang, Lei³ (AUTHOR), Strand, Douglas⁴ (AUTHOR), Lastufka, Chewlan⁵ (AUTHOR), Hosler, Gregory A.^2,5 (AUTHOR), Hon, Gary C.³ (AUTHOR) gary.hon@utsouthwestern.edu

Publikováno v: Molecular Cancer. 11/15/2024, Vol. 23 Issue 1, p1-6. 6p.

Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma.

Autor: Robinson DJ; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London, UK., Patel A; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London, UK., Purdie KJ; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London, UK., Wang J; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary London University, London, UK., Rizvi H; Department of Pathology, Barts Health NHS Trust, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London UK., Hufbauer M; Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany., Ostano P; Cancer Genomics Laboratory, Edo ed Elvo Tempia Foundation, Biella, Italy., Akgül B; Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany., Chiorino G; Cancer Genomics Laboratory, Edo ed Elvo Tempia Foundation, Biella, Italy., Harwood CA; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London, UK., Bergamaschi D; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London, UK. Electronic address: d.bergamaschi@qmul.ac.uk.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2019 Aug; Vol. 139 (8), pp. 1658-1671.e8. Date of Electronic Publication: 2019 Jan 30.

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.

Autor: Inman GJ; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK. g.j.inman@dundee.ac.uk., Wang J; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK. j.a.wang@qmul.ac.uk., Nagano A; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Alexandrov LB; Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Purdie KJ; Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK., Taylor RG; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Sherwood V; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Thomson J; Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK., Hogan S; Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK., Spender LC; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., South AP; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Stratton M; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK., Chelala C; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Harwood CA; Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK., Proby CM; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Leigh IM; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK. i.m.leigh@dundee.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2018 Sep 10; Vol. 9 (1), pp. 3667. Date of Electronic Publication: 2018 Sep 10.

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.

Autor: Rose AM; Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.; Department of Plastic and Reconstructive Surgery, Ninewells Hospital and Medical School, NHS Tayside, Dundee, Scotland, DD1 9SY, UK., Spender LC; Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK., Stephen C; Department of Plastic and Reconstructive Surgery, Ninewells Hospital and Medical School, NHS Tayside, Dundee, Scotland, DD1 9SY, UK., Mitchell A; Department of Dermatology, Ninewells Hospital and Medical School, NHS Tayside, Dundee, Scotland, DD1 9SY, UK., Rickaby W; Dermatopathology Laboratory, St. John's Institute of Dermatology, St.Thomas' Hospital, London, SE1 7EH, UK., Bray S; Tayside Tissue Bank, Ninewells Hospital and Medical School, NHS Tayside, Dundee, Scotland, DD1 9SY, UK., Evans AT; Department of Pathology, Ninewells Hospital and Medical School, NHS Tayside, Dundee, Scotland, DD1 9SY, UK., Dayal J; Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK., Purdie KJ; Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK., Harwood CA; Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK., Proby CM; Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK., Leigh IM; Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.; Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK., Coates PJ; Tayside Tissue Bank, Ninewells Hospital and Medical School, NHS Tayside, Dundee, Scotland, DD1 9SY, UK.; Regional Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, 656 53, Czech Republic., Inman GJ; Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.

Publikováno v: Oncotarget [Oncotarget] 2018 Feb 22; Vol. 9 (18), pp. 14552-14566. Date of Electronic Publication: 2018 Feb 22 (Print Publication: 2018).