Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complicationsResearch in context

Autor: Colette Christiansen, Louis Potier, Tiphaine C. Martin, Sergio Villicaña, Juan E. Castillo-Fernandez, Massimo Mangino, Cristina Menni, Pei-Chien Tsai, Purdey J. Campbell, Shelby Mullin, Juan R. Ordoñana, Olga Monteagudo, Perminder S. Sachdev, Karen A. Mather, Julian N. Trollor, Kirsi H. Pietilainen, Miina Ollikainen, Christine Dalgård, Kirsten Kyvik, Kaare Christensen, Jenny van Dongen, Gonneke Willemsen, Dorret I. Boomsma, Patrik K.E. Magnusson, Nancy L. Pedersen, Scott G. Wilson, Elin Grundberg, Tim D. Spector, Jordana T. Bell

Publikováno v: EBioMedicine, Vol 103, Iss , Pp 105096- (2024)

Summary: Background: Type 2 diabetes (T2D) susceptibility is influenced by genetic and environmental factors. Previous findings suggest DNA methylation as a potential mechanism in T2D pathogenesis and progression. Methods: We profiled DNA methylation

Externí odkaz: https://doaj.org/article/8370902b51f14421bc193f373f4db351

Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9

Autor: Antoine Weihs, Layal Chaker, Tiphaine C. Martin, Kim V.E. Braun, Purdey J. Campbell, Simon R. Cox, Myriam Fornage, Christian Gieger, Hans J. Grabe, Harald Grallert, Sarah E. Harris, Brigitte Kühnel, Riccardo E. Marioni, Nicholas G. Martin, Daniel L. McCartney, Allan F. McRae, Christa Meisinger, Joyce B.J. van Meurs, Jana Nano, Matthias Nauck, Annette Peters, Holger Prokisch, Michael Roden, Elizabeth Selvin, Marian Beekman, Diana van Heemst, Eline P. Slagboom, Brenton R. Swenson, Adrienne Tin, Pei-Chien Tsai, Andre Uitterlinden, W. Edward Visser, Henry Völzke, Melanie Waldenberger, John P. Walsh, Anna Köttgen, Scott G. Wilson, Robin P. Peeters, Jordana T. Bell, Marco Medici, Alexander Teumer

Publikováno v: Weihs, A, Chaker, L, Martin, T C, Braun, K V E, Campbell, P J, Cox, S R, Fornage, M, Gieger, C, Grabe, H J, Grallert, H, Harris, S, Kuhnel, B, Marioni, R E, Martin, N, McCartney, D L, Mcrae, A F, Meisinger, C, van Meurs, J B J, Nano, J, Nauck, M, Peters, A, Prokisch, H, Roden, M, Selvin, E, Beekman, M, van Heemst, D, Slagboom, P E, Swenson, B R, Tin, A, Tsai, P-C, Uitterlinden, A G, Visser, W E, Völzke, H, Waldenberger, M, Walsh, J P, Köttgen, A, Wilson, S G, Peeters, R P, Bell, J T, Medici, M & Teumer, A 2023, ' Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9 ', Thyroid Journal Program, vol. 33, no. 3, pp. 301–311 . https://doi.org/10.1089/thy.2022.0373
Thyroid 33(3), 301-311 (2023). doi:10.1089/thy.2022.0373
Thyroid, 33(3), 301-311. Mary Ann Liebert Inc.

Background: Thyroid hormones play a key role in differentiation and metabolism and are known regulators of gene expression through both genomic and epigenetic processes including DNA methylation. The aim of this study was to examine associations betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f044dc86f46b10e5975d27cc4a844172
https://hdl.handle.net/20.500.11820/324704c8-f3a4-4bb2-ad94-f9ff5b35fa23

Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L

Autor: Gu Zhu, Juan E. Castillo-Fernandez, Shelby Mullin, Scott Wilson, Vijay Panicker, Nicole Lafontaine, Margaret J. Wright, Allan F. McRae, Purdey J Campbell, Phillip E. Melton, John P. Walsh, Jordana T. Bell, Rae-Chi Huang, Nicholas G. Martin, Michelle Lewer, Ee Mun Lim, Phillip Kendrew, Lawrence J. Beilin, Frank Dudbridge, Trevor A. Mori, Tim D. Spector, Suzanne J. Brown

Publikováno v: The Journal of clinical endocrinology and metabolism. 106(5)

Context Circulating concentrations of free triiodothyronine (fT3), free thyroxine (fT4), and thyrotropin (TSH) are partly heritable traits. Recent studies have advanced knowledge of their genetic architecture. Epigenetic modifications, such as DNA me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb118dc9c16ad81055830651e8eada5
https://pubmed.ncbi.nlm.nih.gov/33693780

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Autor: Yolande F. M. Ramos, Tom Fiers, Jari Lahti, Tarunveer S. Ahluwalia, Elisa Kasbohm, Silvia Naitza, Hou-Feng Zheng, Charlotte Cerqueira, Ingrid Meulenbelt, Betina H. Thuesen, Ernst Rietzschel, Anne R. Cappola, John P. Walsh, Alessandro De Grandi, Johan G. Eriksson, Suzanne J. Brown, Jiaojiao Jing, Deborah Mascalzoni, Nicole Soranzo, Daniel Taliun, Margreet Kloppenburg, Purdey J Campbell, Kai-Uwe Eckardt, Yong Li, Mauro Pala, Marco Medici, Florian Kronenberg, Caterina Barbieri, Francesco Cucca, Allan Linneberg, Anna Köttgen, Bruce M. Psaty, Eric Boerwinkle, Ian J. Deary, Jennie Hui, Joris Deelen, Matthijs Moed, Astrid Petersmann, Graziano Ceresini, Michela Marina, Iris Postmus, Alice M. Arnold, Michiaki Kubo, J. Brent Richards, Marc De Buyzere, Henriette E. Meyer zu Schwabedissen, Eleonora Porcu, Christian Fuchsberger, Celia Di Munno, Dan E. Arking, David J. Stott, Toshiko Tanaka, Sofie Bekaert, Andrew A. Hicks, W. Edward Visser, Wouter den Hollander, Martin Gögele, Cinzia Sala, Peter P. Pramstaller, Georg Homuth, Yukinori Okada, Arne Astrup, Arif B. Ekici, Ulla T. Schultheiss, Richard A. Jensen, Christa Meisinger, Romana T. Netea-Maier, Rafael T. Mikolajczyk, Theo J. Visser, Marian Beekman, Michela Traglia, David C. Liewald, Koichi Matsuda, Thorkild I. A. Sørensen, Ilja M. Nolte, André G. Uitterlinden, David Schlessinger, Luigi Ferrrucci, Shuo Li, Alexander Teumer, Daniel Tiller, Sarah E. Harris, J. Wouter Jukema, Rajesh Rawal, Tim De Meyer, Kadri Haljas, Greet Roef, Yoichiro Kamatani, Karin Halina Greiser, Jean-Marc Kaufman, Serena Sanna, Bruce H. R. Wolffenbuttel, Scott Wilson, Daniela Toniolo, Ee Mun Lim, Stefan Groeneweg, Caroline S. Fox, Torben Hansen, Masato Akiyama, Christian Gieger, Layal Chaker, Tim D. Spector, Ian Ford, Martin den Heijer, P. Eline Slagboom, Elizabeth Selvin, Lambertus A. Kiemeney, Emil V. R. Appel, Niels Grarup, Diana van Heemst, Youri Taes, Robin P. Peeters, Henry Völzke, Cristian Pattaro, Daniel Medenwald, John M. Starr, Qiong Yang, Jerome I. Rotter, M. Arfan Ikram, Edoardo Fiorillo, Till Ittermann, Oluf Pedersen, Eero Kajantie, John Beilby, Tessel E. Galesloot, Fernando Rivadeneira, Paul Redmond, Bruno Lapauw

Publikováno v: Nature communications, vol. 9, no. 1, pp. 4455
Nature Communications, 9(1):4455. Nature Publishing Group
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Teumer, A, Chaker, L, Groeneweg, S, Li, Y, Di Munno, C, Barbieri, C, Ahluwalia, T S, Astrup, A, Linneberg, A, Pedersen, O B, Sørensen, T I A & ThyroidOmics Consortium 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, 4455 . https://doi.org/10.1038/s41467-018-06356-1
Nat. Commun. 9:4455 (2018)
Lifelines Cohort Study 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, no. 1, 4455 . https://doi.org/10.1038/s41467-018-06356-1
Nat Commun
Nature Communications, 9:4455. Nature Publishing Group
Teumer, A, Chaker, L, Groeneweg, S, Li, Y, Di Munno, C, Barbieri, C, Schultheiss, U T, Traglia, M, Ahluwalia, T S, Akiyama, M, Appel, E V R, Arking, D E, Arnold, A, Astrup, A, Beekman, M, Beilby, J P, Bekaert, S, Boerwinkle, E, Brown, S J, De Buyzere, M, Campbell, P J, Ceresini, G, Cerqueira, C, Cucca, F, Deary, I J, Deelen, J, Eckardt, K-U, Ekici, A B, Eriksson, J G, Ferrrucci, L, Fiers, T, Fiorillo, E, Ford, I, Fox, C S, Fuchsberger, C, Galesloot, T E, Gieger, C, Gögele, M, De Grandi, A, Grarup, N, Greiser, K H, Haljas, K, Hansen, T, Harris, S E, van Heemst, D, den Heijer, M, Hicks, A A, Liewald, D C M, Redmond, P, Starr, J M, Stott, D J, Taes, Y E, Taliun, D, Toshiko, T, Thuesen, B, Tiller, D, Toniolo, D, Uitterlinden, A G, Visser, W E, Walsh, J P, Wilson, S G, Wolffenbuttel, B H R, Yang, Q, Zheng, H-F, Cappola, A R, Peeters, R P, Naitza, S, Völzke, H, Sanna, S, Köttgen, A, Visser, T J & Medici, M 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, no. 1, pp. 1-14 . https://doi.org/10.1038/s41467-018-06356-1
NATURE COMMUNICATIONS

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121e7b6174ad0cbd3fcf7d39e1f917e5
https://hdl.handle.net/1765/111651

Common genetic variants associated with thyroid function may be risk alleles for Hashimoto's disease and Graves' disease

Autor: Jennie Hui, Thomas Heiberg Brix, John P. Walsh, Laszlo Hegedüs, Purdey J Campbell, John Beilby, Scott Wilson, L.C. Ward

Publikováno v: Brix, T H & Hegedüs, L 2016, ' Common genetic variants Associated with thyroid function may be risk alleles for Hashimoto's disease and Graves disease ', Clinical Endocrinology, vol. 84, no. 2, pp. 278-283 . https://doi.org/10.1111/cen.12746

Background Recent studies have identified common genetic variants associated with TSH, free T4 and thyroid peroxidase antibodies, but it is unclear whether these differ between patients with Hashimoto's disease and Graves' disease. Objective To exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a595ad20c95c35bf779d85cd7469f7c
https://pubmed.ncbi.nlm.nih.gov/25683181