Comparative study of naturally occurring Huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

Autor: Barbaro, Brett A, Lukacsovich, Tamas, Agrawal, Namita, Burke, John, Bornemann, Doug J, Purcell, Judith M, Worthge, Shane A, Caricasole, Andrea, Weiss, Andreas, Song, Wan, Morozova, Olga A, Colby, David W, Marsh, J Lawrence

Publikováno v: Barbaro, BA; Lukacsovich, T; Agrawal, N; Burke, J; Bornemann, DJ; Purcell, JM; et al.(2015). Comparative study of naturally occurring Huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease. Human Molecular Genetics, 24(4), 913-925. doi: 10.1093/hmg/ddu504. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/980460q5
Human molecular genetics, vol 24, iss 4

© The Author 2014. Published by Oxford University Press. All rights reserved. Although Huntington's disease is caused by the expansion of a CAG triplet repeat within the context of the 3144-amino acid huntingtin protein (HTT), studies reveal that N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::887b6afa2c9e578776ab33d24256ee3e
http://www.escholarship.org/uc/item/980460q5

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