Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

Autor: Writing Committee for the REMAP-CAP Investigators, Estcourt, Lise J, Turgeon, Alexis F, McQuilten, Zoe K, McVerry, Bryan J, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Arnold, Donald M, Beane, Abigail, Bégin, Philippe, van Bentum-Puijk, Wilma, Berry, Lindsay R, Bhimani, Zahra, Birchall, Janet E, Bonten, Marc JM, Bradbury, Charlotte A, Brunkhorst, Frank M, Buxton, Meredith, Callum, Jeannie L, Chassé, Michaël, Cheng, Allen C, Cove, Matthew E, Daly, James, Derde, Lennie, Detry, Michelle A, De Jong, Menno, Evans, Amy, Fergusson, Dean A, Fish, Matthew, Fitzgerald, Mark, Foley, Claire, Goossens, Herman, Gordon, Anthony C, Gosbell, Iain B, Green, Cameron, Haniffa, Rashan, Harvala, Heli, Higgins, Alisa M, Hills, Thomas E, Hoad, Veronica C, Horvat, Christopher, Huang, David T, Hudson, Cara L, Ichihara, Nao, Laing, Emma, Lamikanra, Abigail A, Lamontagne, François, Lawler, Patrick R, Linstrum, Kelsey, Litton, Edward, Lorenzi, Elizabeth, MacLennan, Sheila, Marshall, John, McAuley, Daniel F, McDyer, John F, McGlothlin, Anna, McGuinness, Shay, Miflin, Gail, Montgomery, Stephanie, Mouncey, Paul R, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane C, Priddee, Nicole, Purcell, Damian FJ, Reyes, Luis F, Richardson, Peter, Robitaille, Nancy, Rowan, Kathryn M, Rynne, Jennifer, Saito, Hiroki, Santos, Marlene, Saunders, Christina T, Serpa Neto, Ary, Seymour, Christopher W, Silversides, Jon A, Tinmouth, Alan A, Triulzi, Darrell J, Turner, Anne M, van de Veerdonk, Frank, Walsh, Timothy S, Wood, Erica M, Berry, Scott, Lewis, Roger J, Menon, David K, McArthur, Colin, Zarychanski, Ryan, Angus, Derek C, Webb, Steve A, Roberts, David J, Shankar-Hari, Manu

Publikováno v: Investigators, W C F T REMAP-CAP & Dark, P 2021, ' Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial ', JAMA, vol. 326, no. 17, pp. 1690-1702 . https://doi.org/10.1001/jama.2021.18178
JAMA : the journal of the American Medical Association
JAMA
34th annual congress of European Society of Intensive Care Medicine
34th annual congress of European Society of Intensive Care Medicine, Oct 2021, unknow, France. pp.1690-1702, ⟨10.1001/jama.2021.18178⟩
Jama : Journal of the American Medical Association, 326, 1690-1702
unknow
unknow, 2021, unknow, France. pp.1690-1702, ⟨10.1001/jama.2021.18178⟩
Investigators, W C F T REMAP-CAP, Estcourt, L J, Turgeon, A F, McQuilten, Z K, McVerry, B J, Al-Beidh, F, Annane, D, Arabi, Y M, Arnold, D M, Beane, A, Bégin, P, van Bentum-Puijk, W, Berry, L R, Bhimani, Z, Birchall, J E, Bonten, M J M, Bradbury, C A, Brunkhorst, F M, Buxton, M, Callum, J L, Chassé, M, Cheng, A C, Cove, M E, Daly, J, Derde, L, Detry, M A, De Jong, M, Evans, A, Fergusson, D A, Fish, M, Fitzgerald, M, Foley, C, Goossens, H, Gordon, A C, Gosbell, I B, Green, C, Haniffa, R, Harvala, H, Higgins, A M, Hills, T E, Hoad, V C, Horvat, C, Huang, D T, Hudson, C L, Ichihara, N, Laing, E, Lamikanra, A A, Lamontagne, F, Lawler, P R, Rynne, J & Shankar-Hari, M 2021, ' Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial ', Journal of the American Medical Association, vol. 326, no. 17, pp. 1690-1702 . https://doi.org/10.1001/jama.2021.18178
JAMA-Journal of the American Medical Association, 326(17), 1690-1702. American Medical Association
Jama : Journal of the American Medical Association, 326, 17, pp. 1690-1702
Writing Committee for the REMAP-CAP Investigators 2021, ' Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial ', JAMA: Journal of the American Medical Association . https://doi.org/10.1001/jama.2021.18178
Estcourt, L J 2021, ' Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19 : A Randomized Clinical Trial ', JAMA-Journal of the American Medical Association, vol. 326, no. 17, pp. 1690-1702 . https://doi.org/10.1001/jama.2021.18178

Importance The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.Objective To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.Design, Setting, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5411dee342a00905d406981de787b5dd
https://www.research.manchester.ac.uk/portal/en/publications/effect-of-convalescent-plasma-on-organ-supportfree-days-in-critically-ill-patients-with-covid19-a-randomized-clinical-trial(fb90b165-eddb-44e0-81ee-5ac2b180c546).html

Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants emerging during AIDS progression

Autor: Karlsson Anders, Purcell Damian FJ, Churchill Melissa J, Sterjovski Jasminka, Kuylenstierna Carlotta, Repits Johanna, Borggren Marie, Albert Jan, Gorry Paul R, Jansson Marianne

Publikováno v: Retrovirology, Vol 5, Iss 1, p 28 (2008)

Abstract Background At early stages of infection CCR5 is the predominant HIV-1 coreceptor, but in approximately 50% of those infected CXCR4-using viruses emerge with disease progression. This coreceptor switch is correlated with an accelerated progre

Externí odkaz: https://doaj.org/article/a3de39fd754244e5945f7208ada29a4e

Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

Autor: Wang Bin, Saksena Nitin, Purcell Damian FJ, Dunfee Rebecca L, Roche Michael J, Gray Lachlan R, Ellett Anne, Churchill Melissa J, Sterjovski Jasminka, Sonza Secondo, Wesselingh Steven L, Karlsson Ingrid, Fenyo Eva-Maria, Gabuzda Dana, Cunningham Anthony L, Gorry Paul R

Publikováno v: Retrovirology, Vol 4, Iss 1, p 89 (2007)

Abstract Background CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1) variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the pathogenicity of R5 strains are poorly understood.

Externí odkaz: https://doaj.org/article/167d98a13939480d8a01f23df55472b8

No adverse safety or virological changes two years following vorinostat in HIV-infected individuals on antiretroviral therapy

Autor: MOTA, Talia M, RASMUSSEN, Thomas A, RHODES, Ajantha, TENNAKOON, Surekha, DANTANARAYANA, Ashanti, WIGHTMAN, Fiona, HAGENAUER, Michelle, RONEY, Janine, SPELMAN, Tim, PURCELL, Damian FJ, McMAHON, James, HOY, Jennifer F, PRINCE, H. Miles, ELLIOTT, Julian H, LEWIN, Sharon R

Publikováno v: Mota, T M, Rasmussen, T A, Rhodes, A, Tennakoon, S, Dantanarayana, A, Wightman, F, Hagenauer, M, Roney, J, Spelman, T, Purcell, D F J, McMahon, J, Hoy, J F, Prince, H M, Elliott, J H & Lewin, S R 2017, ' No adverse safety or virological changes two years following vorinostat in HIV-infected individuals on antiretroviral therapy ', AIDS . https://doi.org/10.1097/QAD.0000000000001442

OBJECTIVE: To determine the long term effects of vorinostat on safety and virological parameters in HIV-infected individuals on suppressive antiretroviral therapy (ART).DESIGN: Prospective longitudinal observational extended follow up of 20 HIV-infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::67ddc6040ff87095d153efc9b1c30bb8
https://pure.au.dk/portal/da/publications/no-adverse-safety-or-virological-changes-two-years-following-vorinostat-in-hivinfected-individuals-on-antiretroviral-therapy(9b0b3099-b3f3-44b6-9626-b681eb6c2e25).html

MYB Elongation Is Regulated by the Nucleic Acid Binding of NFκB p50 to the Intronic Stem-Loop Region

Autor: S Gerondakis, Secondo Sonza, Robert G. Ramsay, Honor J. Hugo, Paul A. Ramsland, Xu Huiling, Alina Cures, Damian F. J. Purcell, Thomas J. Gonda, Lloyd Pereira, Jordane Malaterre

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0122919 (2015)

MYB transcriptional elongation is regulated by an attenuator sequence within intron 1 that has been proposed to encode a RNA stem loop (SLR) followed by a polyU tract. We report that NFekBp50 can bind the SLR polyU RNA and promote MYB transcriptional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4de632bf9f2fad461b94247d91fd56
https://doi.org/10.1371/journal.pone.0122919