Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Pura Muñoz Cánoves"'
Autor:
Pablo Gómez-del Arco, Joan Isern, Daniel Jimenez-Carretero, Dolores López-Maderuelo, Rebeca Piñeiro-Sabarís, Fadoua El Abdellaoui-Soussi, Carlos Torroja, María Linarejos Vera-Pedrosa, Mercedes Grima-Terrén, Alberto Benguria, Ana Simón-Chica, Antonio Queiro-Palou, Ana Dopazo, Fátima Sánchez-Cabo, José Jalife, José Luis de la Pompa, David Filgueiras-Rama, Pura Muñoz-Cánoves, Juan Miguel Redondo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Extensive genetic studies have elucidated cardiomyocyte differentiation and associated gene networks using single-cell RNA-seq, yet the intricate transcriptional mechanisms governing cardiac conduction system (CCS) development and working ca
Externí odkaz:
https://doaj.org/article/6e6e018aa0f54c20af7b9385311cf831
Autor:
Jacob G. Smith, Kevin B. Koronowski, Thomas Mortimer, Tomoki Sato, Carolina M. Greco, Paul Petrus, Amandine Verlande, Siwei Chen, Muntaha Samad, Ekaterina Deyneka, Lavina Mathur, Ronnie Blazev, Jeffrey Molendijk, Arun Kumar, Oleg Deryagin, Mireia Vaca-Dempere, Valentina Sica, Peng Liu, Valerio Orlando, Benjamin L. Parker, Pierre Baldi, Patrick-Simon Welz, Cholsoon Jang, Selma Masri, Salvador Aznar Benitah, Pura Muñoz-Cánoves, Paolo Sassone-Corsi
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112588- (2023)
Summary: Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions between clocks in
Externí odkaz:
https://doaj.org/article/da43be69311647c3a3d0a4fdfd5731ef
Autor:
Coralie Arc‐Chagnaud, Andrea Salvador‐Pascual, Esther Garcia‐Dominguez, Gloria Olaso‐Gonzalez, Angela G. Correas, Eva Serna, Thomas Brioche, Angele Chopard, Pablo J. Fernandez‐Marcos, Manuel Serrano, Antonio L. Serrano, Pura Muñoz‐Cánoves, Vicente Sebastiá, Jose Viña, Mari Carmen Gomez‐Cabrera
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1879-1896 (2021)
Abstract Background Frailty is a major age‐associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phospha
Externí odkaz:
https://doaj.org/article/d578ec5a5bac46bd960a9fac37238ac8
Autor:
Xiaona Chen, Jie Yuan, Guang Xue, Silvia Campanario, Di Wang, Wen Wang, Xi Mou, Shiau Wei Liew, Mubarak Ishaq Umar, Joan Isern, Yu Zhao, Liangqiang He, Yuying Li, Christopher J. Mann, Xiaohua Yu, Lei Wang, Eusebio Perdiguero, Wei Chen, Yuanchao Xue, Yoshikuni Nagamine, Chun Kit Kwok, Hao Sun, Pura Muñoz-Cánoves, Huating Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Skeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRN
Externí odkaz:
https://doaj.org/article/6dfdbd5e24c94a98ae8d2a286fba0f68
Autor:
Belén Prados, Raquel del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2 expression is
Externí odkaz:
https://doaj.org/article/d4a09a541c4243abba6f5b49417ad8d7
Autor:
Omid Mashinchian, Xiaotong Hong, Joris Michaud, Eugenia Migliavacca, Gregory Lefebvre, Christophe Boss, Filippo De Franceschi, Emmeran Le Moal, Jasmin Collerette-Tremblay, Joan Isern, Sylviane Metairon, Frederic Raymond, Patrick Descombes, Nicolas Bouche, Pura Muñoz-Cánoves, Jerome N Feige, C Florian Bentzinger
Publikováno v:
eLife, Vol 11 (2022)
Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on s
Externí odkaz:
https://doaj.org/article/e06534e7b8fc4105bcfcb17a74fd6563
Autor:
Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ageing is associated with muscle atrophy, which negatively impacts quality of life. Here the authors show that expression of sestrins decreases during inactivity and that their overexpression prevents atrophy in mice via modulation of autophagy and p
Externí odkaz:
https://doaj.org/article/36ab756e6fc848bfb843ed2f784d654b
Autor:
Stefania Dell’Orso, Aster H. Juan, Victoria Moiseeva, Laura García-Prat, Pura Muñoz-Cánoves, Vittorio Sartorelli
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100451- (2021)
Summary: It remains challenging to generate reproducible, high-quality cDNA libraries from RNA derived from rare cell populations. Here, we describe a protocol for high-throughput RNA-seq library preparation, including isolation of 200 skeletal muscl
Externí odkaz:
https://doaj.org/article/87f3e232f70549a0bd53c2ebf364a1f9
Publikováno v:
The FEBS Journal. 290:1156-1160
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
The skeletal muscle tissue in the adult is relatively stable under normal conditions but retains a striking ability to regenerate by its resident stem cells (satellite cells). Satellite cells exist in a quiescent (G0) state; however, in response to a
Externí odkaz:
https://doaj.org/article/77436b5bb125402bb8b9e6fc5b8d7c04