Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Punit P Seth"'
Autor:
Noriko Satake, Connie Duong, Sakiko Yoshida, Michael Oestergaard, Cathy Chen, Rachael Peralta, Shuling Guo, Punit P Seth, Yueju Li, Laurel Beckett, Jong Chung, Jan Nolta, Nitin Nitin, Joseph M Tuscano
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 632-642 (2016)
Abstract The exponential rise in molecular and genomic data has generated a vast array of therapeutic targets. Oligonucleotide-based technologies to down regulate these molecular targets have promising therapeutic efficacy. However, there is relative
Externí odkaz:
https://doaj.org/article/88710ac9246b4db68143aad6fabf9036
Autor:
Rosie Z Yu, Mark J Graham, Noah Post, Stan Riney, Thomas Zanardi, Shannon Hall, Jennifer Burkey, Colby S Shemesh, Thazha P Prakash, Punit P Seth, Eric E Swayze, Richard S Geary, Yanfeng Wang, Scott Henry
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Triantennary N-acetyl galactosamine (GalNAc3)-conjugated antisense oligonucleotides (ASOs) have greatly improved potency via receptor-mediated uptake. In the present study, the in vivo pharmacology of a 2′-O-(2-methoxyethyl)-modified ASO conjugated
Externí odkaz:
https://doaj.org/article/2b26807b841244429f7ffc38c01b9c47
Autor:
Colby S Shemesh, Rosie Z Yu, Hans J Gaus, Sarah Greenlee, Noah Post, Karsten Schmidt, Michael T Migawa, Punit P Seth, Thomas A Zanardi, Thazha P Prakash, Eric E Swayze, Scott P Henry, Yanfeng Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Triantennary N-acetyl galactosamine (GalNAc3) is a high-affinity ligand for hepatocyte-specific asialoglycoprotein receptors. Conjugation with GalNAc3 via a trishexylamino (THA)-C6 cluster significantly enhances antisense oligonucleotide (ASO) potenc
Externí odkaz:
https://doaj.org/article/1de8c3f8738147bdba5db5c61c7a342f
Autor:
Niels H Skotte, Amber L Southwell, Michael E Østergaard, Jeffrey B Carroll, Simon C Warby, Crystal N Doty, Eugenia Petoukhov, Kuljeet Vaid, Holly Kordasiewicz, Andrew T Watt, Susan M Freier, Gene Hung, Punit P Seth, C Frank Bennett, Eric E Swayze, Michael R Hayden
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107434 (2014)
Huntington disease (HD) is an inherited, fatal neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The mutant protein causes neuronal dysfunction and degeneration resulting in motor dysfunction, cognitive decline, and
Externí odkaz:
https://doaj.org/article/df087f84149f4dfba0bfc4bdc1b0f552
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenge
Externí odkaz:
https://doaj.org/article/8c5e85e956db43fd9c8eef64ef89f14a
Autor:
Tamilselvan Rajasekaran, Graeme C. Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Hans Gaus, Michael T. Migawa, Eric. E. Swayze, Thomas E. Cheatham, Punit P. Seth, Stephen Hanessian
Publikováno v:
The Journal of Organic Chemistry. 88:3599-3614
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b43ee8621b506c8e97b1ef94a57433
https://doi.org/10.1021/acs.joc.2c02796
https://doi.org/10.1021/acs.joc.2c02796
Autor:
Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken, Daniel Gil, David A Fruman, Stephen Hanessian, Punit P Seth, Aimee L Edinger
Publikováno v:
Nucleic Acids Research. 51:1583-1599
Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fde1b5fd23940ce7c0ce0235ad04603
https://doi.org/10.1093/nar/gkad023
https://doi.org/10.1093/nar/gkad023
Autor:
Lingdi Zhang, Xue-hai Liang, Cheryl Li De Hoyos, Michael Migawa, Joshua G. Nichols, Graeme Freestone, Jun Tian, Punit P. Seth, Stanley T. Crooke
Publikováno v:
Nucleic Acid Therapeutics. 32:401-411
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d010ee80d944483c78c624b02605c89a
https://doi.org/10.1089/nat.2022.0005
https://doi.org/10.1089/nat.2022.0005
Autor:
Carol Kuo, Mehran Nikan, Steve T. Yeh, Alfred E. Chappell, Michael Tanowitz, Punit P. Seth, Thazha P. Prakash, Adam E. Mullick
Publikováno v:
Nucleic Acid Therapeutics. 32:300-311
We evaluated the potential of AGTR1, the principal receptor for angiotensin II (Ang II) and a member of the G protein-coupled receptor family, for targeted delivery of antisense oligonucleotides (ASOs) in cells and tissues with abundant AGTR1 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ee6aa1a4013b0e736d0df0e0f37770
https://doi.org/10.1089/nat.2021.0105
https://doi.org/10.1089/nat.2021.0105
Autor:
W. Brad Wan, Audrey Low, Eric E. Swayze, Michael T. Migawa, Guillermo Vasquez, Michael Tanowitz, Punit P. Seth
Publikováno v:
Nucleic Acid Therapeutics. 32:40-50
The phosphorothioate (PS) linkage in an essential component of therapeutic oligonucleotides. PS in the DNA region of gapmer antisense oligonucleotides (ASOs) supports RNaseH1 activity and enhances nuclease stability. PS also promotes binding to plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a3100ea938ad4987b8358f461c08ec
https://doi.org/10.1089/nat.2021.0064
https://doi.org/10.1089/nat.2021.0064