Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Puneeth, Iyengar"'
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
Autor:
Yichi Zhang, Matthieu Dos Santos, Huocong Huang, Kenian Chen, Puneeth Iyengar, Rodney Infante, Patricio M. Polanco, Rolf A. Brekken, Chunyu Cai, Ambar Caijgas, Karla Cano Hernandez, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114587- (2024)
Summary: Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully reversed with nutritional interventions. Muscle atrophy is a central component of the syndrome, but the mechanisms whereby cancer leads to skeletal muscle
Externí odkaz:
https://doaj.org/article/178060e694dc445f9c9795570d7dc38d
Autor:
Khushi Kohli, Erin Jay G. Feliciano, Nishwant Swami, Aditya Narayan, Tej A. Patel, Bhav Jain, Puneeth Iyengar, Julie Kanevsky, Paul L. Nguyen, Edward Christopher Dee
Publikováno v:
The Lancet Regional Health. Americas, Vol 35, Iss , Pp 100776- (2024)
Externí odkaz:
https://doaj.org/article/9dc76bc1ba564709b531465e477d8151
Publikováno v:
The Lancet Regional Health. Americas, Vol 25, Iss , Pp 100573- (2023)
Externí odkaz:
https://doaj.org/article/bdaf44d1406e4329903b240070e564f2
Autor:
Linda Anne Gilmore, Santiago Olaechea, Brian W. Gilmore, Bhavani S. Gannavarapu, Christian M. Alvarez, Chul Ahn, Puneeth Iyengar, Rodney E. Infante
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 2920-2931 (2022)
Abstract Background Cancer cachexia is frequently documented by self‐reported, single time‐point weight histories. This approach lacks the granularity needed to fully elucidate the progression of cachexia syndrome. This study aimed to longitudina
Externí odkaz:
https://doaj.org/article/8fe65dbca99243858afc6ef020d6cf80
Autor:
Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Cancer cachexia (CC), a wasting syndrome of muscle and adipose tissue resulting in weight loss, is observed in 50% of patients with solid tumors. Management of CC is limited by the absence of biomarkers and knowledge of molecules that drive its pheno
Externí odkaz:
https://doaj.org/article/6f7581b120d34f2291bd9e772c731785
Autor:
Tingliang Zhuang, Grant Gibbard, Xinhui Duan, Jun Tan, Yang Park, Mu-Han Lin, Zhihui Sun, Oluwaseyi M. Oderinde, Weiguo Lu, Robert Reynolds, Andrew Godley, Arnold Pompos, Tu Dan, Aurelie Garant, Puneeth Iyengar, Robert Timmerman, Steve Jiang, Bin Cai
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 26, Iss , Pp 100438- (2023)
Background and Purpose: A recently developed biology-guided radiotherapy platform, equipped with positron emission tomography (PET) and computed tomography (CT), provides both anatomical and functional image guidance for radiotherapy. This study aime
Externí odkaz:
https://doaj.org/article/4dfe8b51428c44bcb75e03617f87a548
Autor:
Santiago Olaechea, MS, Alison Liu, BA, Brandon Sarver, BS, Linda Anne Gilmore, PhD, Christian Alvarez, BS, Kayvon Yazdanbakhsh, MPH, Rodney Infante, MD, PhD, Puneeth Iyengar, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 4, Pp 100496- (2023)
Introduction: Cancer cachexia, found in more than a third of patients with NSCLC, directly leads to functional and survival detriments. As screening and interventions for cachexia and NSCLC improve, deficits in health care access and quality among pa
Externí odkaz:
https://doaj.org/article/b2b70ef58e75486a89e409ab9152ded0
Autor:
Eric J. Hsu, PhD, Jameson T. Mendel, MD, Kristin A. Ward, MD, Mariam El-Ashmawy, MD, Minjae Lee, PhD, Hak Choy, MD, Kenneth D. Westover, MD, PhD, Dat T. Vo, MD, PhD, Robert D. Timmerman, MD, David J. Sher, MD, Puneeth Iyengar, MD, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 5, Pp 100995- (2022)
Purpose: : Five-fraction stereotactic ablative radiotherapy (SABR) regimens are frequently used to treat centrally located early-stage non-small cell lung cancer or disease in the proximity of the chest wall as a means of optimizing tumor control and
Externí odkaz:
https://doaj.org/article/b74d8f81cb8a41bfa5b27c2798aa74a3
Autor:
Santiago Olaechea, Bhavani S. Gannavarapu, Christian Alvarez, Anne Gilmore, Brandon Sarver, Donglu Xie, Rodney Infante, Puneeth Iyengar
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
AimTo investigate the diagnostic potential of and associations between tumor 18F‐FDG uptake on PET imaging and cancer-associated weight loss.Methods774 non-small cell lung cancer (NSCLC) patients with pre-treatment PET evaluated between 2006 and 20
Externí odkaz:
https://doaj.org/article/0ac776c9a65546baa1d4a155d3aa9fc9
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Adipose tissue inflammation is observed in multiple metabolically-altered states including cancer-associated cachexia and obesity. Although cachexia is a syndrome of adipose loss and obesity is a disease of adipose excess, both pathologies demonstrat
Externí odkaz:
https://doaj.org/article/61d7a3af16984b2dac23b12a39cc1942